Publications of the Week Integration of Biological/Pathophysiological Contexts to Help Clarify Genotype-Phenotype Mismatches in Monogenetic Diseases. Childhood Epilepsies Associated with SCN2A as a Case Study Monogenetic diseases offer clear human validation for launching drug discovery programs in Pharma designed to…sciencecityJanuary 24, 2018
Publications of the Week Hyaluronan-Binding by CD44 Reduces the Memory Potential of Activated Murine CD8 T Cells In this paper, we found that CD44 and its interaction with its ligand, the extracellular…sciencecityJanuary 22, 2018
Publications of the Week ChopStitch: Exon Annotation and Splice Graph Construction Using Transcriptome Assembly and Whole Genome Sequencing Data Read the Publication This week we profile a recent publication in Bioinformatics from Dr. Inanc…sciencecityJanuary 19, 2018
Publications of the Week REVIEW: Translational Control of Aberrant Stress Responses as a Novel Hallmark of Cancer Altered mRNA translational control is emerging as a critical factor in cancer development and progression.…sciencecityJanuary 18, 2018
Publications of the Week A Library-Based Screening Method Identifies Neoantigen-Reactive T Cells in Peripheral Blood Prior to Relapse of Ovarian Cancer Mutated cancer antigens, or neoantigens, represent compelling immunological targets and appear to underlie the success…sciencecityJanuary 16, 2018
Publications of the Week Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene…sciencecityJanuary 15, 2018
Publications of the Week Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function Synaptopathies contributing to neurodevelopmental disorders are linked to mutations in synaptic organizing molecules, including postsynaptic…sciencecityJanuary 12, 2018
Publications of the Week NEWS & VIEWS: Bacterial Genomics of Plant Adaptation What allows bacteria, both pathogens and mutualists alike, to survive in close association with a…sciencecityJanuary 8, 2018
Publications of the Week NEWS & VIEWS: Bacterial Genomics of Plant Adaptation What allows bacteria, both pathogens and mutualists alike, to survive in close association with a…mjoyJanuary 8, 2018
Publications of the Week TGF-β1 Up-Regulates Cadherin-11 Expression through Snail: A Potential Mechanism for Human Trophoblast Cell Differentiation Cadherins are transmembrane proteins that mediate cell-cell adhesion by promoting the formation of adherens junctions.…sciencecityJanuary 5, 2018