BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Science in Vancouver - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Science in Vancouver
X-ORIGINAL-URL:https://scienceinvancouver.com
X-WR-CALDESC:Events for Science in Vancouver
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Vancouver
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220706T160000
DTEND;TZID=America/Vancouver:20220709T123000
DTSTAMP:20260615T235322
CREATED:20220704T173355Z
LAST-MODIFIED:20220704T173355Z
UID:23034-1657123200-1657369800@scienceinvancouver.com
SUMMARY:International Developmental Coordination Disorder Conference
DESCRIPTION:The theme of the 2022 conference is: DCD in the Real World.\nIt is 20 years since Canada hosted the International DCD Conference in Banff\, Alberta. We are excited to welcome our DCD colleagues to beautiful Vancouver\, British Columbia for DCD-14.  We look forward to having you share the latest understanding of DCD in the real world through presentations of systematic reviews\, scoping reviews\, meta-analyses\, and realist syntheses that summarize what has been learned. We invite you to present original research and knowledge translation work of all types of methodologies and approaches that shed light on improving the lives of individuals with DCD across the lifespan.
URL:https://scienceinvancouver.com/event/international-developmental-coordination-disorder-conference/
LOCATION:Sheraton Vancouver Wall Centre\, 1088 Burrard street\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220706T160000
DTEND;TZID=America/Vancouver:20220709T123000
DTSTAMP:20260615T235322
CREATED:20220704T173355Z
LAST-MODIFIED:20220704T173355Z
UID:26570-1657123200-1657369800@scienceinvancouver.com
SUMMARY:International Developmental Coordination Disorder Conference
DESCRIPTION:The theme of the 2022 conference is: DCD in the Real World.\nIt is 20 years since Canada hosted the International DCD Conference in Banff\, Alberta. We are excited to welcome our DCD colleagues to beautiful Vancouver\, British Columbia for DCD-14.  We look forward to having you share the latest understanding of DCD in the real world through presentations of systematic reviews\, scoping reviews\, meta-analyses\, and realist syntheses that summarize what has been learned. We invite you to present original research and knowledge translation work of all types of methodologies and approaches that shed light on improving the lives of individuals with DCD across the lifespan.
URL:https://scienceinvancouver.com/event/international-developmental-coordination-disorder-conference-2/
LOCATION:Sheraton Vancouver Wall Centre\, 1088 Burrard street\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220706T160000
DTEND;TZID=America/Vancouver:20220709T123000
DTSTAMP:20260615T235322
CREATED:20220704T173355Z
LAST-MODIFIED:20220704T173355Z
UID:28185-1657123200-1657369800@scienceinvancouver.com
SUMMARY:International Developmental Coordination Disorder Conference
DESCRIPTION:The theme of the 2022 conference is: DCD in the Real World.\nIt is 20 years since Canada hosted the International DCD Conference in Banff\, Alberta. We are excited to welcome our DCD colleagues to beautiful Vancouver\, British Columbia for DCD-14.  We look forward to having you share the latest understanding of DCD in the real world through presentations of systematic reviews\, scoping reviews\, meta-analyses\, and realist syntheses that summarize what has been learned. We invite you to present original research and knowledge translation work of all types of methodologies and approaches that shed light on improving the lives of individuals with DCD across the lifespan.
URL:https://scienceinvancouver.com/event/international-developmental-coordination-disorder-conference-3/
LOCATION:Sheraton Vancouver Wall Centre\, 1088 Burrard street\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220706T160000
DTEND;TZID=America/Vancouver:20220709T123000
DTSTAMP:20260615T235322
CREATED:20220704T173355Z
LAST-MODIFIED:20220704T173355Z
UID:31268-1657123200-1657369800@scienceinvancouver.com
SUMMARY:International Developmental Coordination Disorder Conference
DESCRIPTION:The theme of the 2022 conference is: DCD in the Real World.\nIt is 20 years since Canada hosted the International DCD Conference in Banff\, Alberta. We are excited to welcome our DCD colleagues to beautiful Vancouver\, British Columbia for DCD-14.  We look forward to having you share the latest understanding of DCD in the real world through presentations of systematic reviews\, scoping reviews\, meta-analyses\, and realist syntheses that summarize what has been learned. We invite you to present original research and knowledge translation work of all types of methodologies and approaches that shed light on improving the lives of individuals with DCD across the lifespan.
URL:https://scienceinvancouver.com/event/international-developmental-coordination-disorder-conference-4/
LOCATION:Sheraton Vancouver Wall Centre\, 1088 Burrard street\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220706T160000
DTEND;TZID=America/Vancouver:20220709T123000
DTSTAMP:20260615T235322
CREATED:20220704T173355Z
LAST-MODIFIED:20220704T173355Z
UID:32728-1657123200-1657369800@scienceinvancouver.com
SUMMARY:International Developmental Coordination Disorder Conference
DESCRIPTION:The theme of the 2022 conference is: DCD in the Real World.\nIt is 20 years since Canada hosted the International DCD Conference in Banff\, Alberta. We are excited to welcome our DCD colleagues to beautiful Vancouver\, British Columbia for DCD-14.  We look forward to having you share the latest understanding of DCD in the real world through presentations of systematic reviews\, scoping reviews\, meta-analyses\, and realist syntheses that summarize what has been learned. We invite you to present original research and knowledge translation work of all types of methodologies and approaches that shed light on improving the lives of individuals with DCD across the lifespan.
URL:https://scienceinvancouver.com/event/international-developmental-coordination-disorder-conference-5/
LOCATION:Sheraton Vancouver Wall Centre\, 1088 Burrard street\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220708T090000
DTEND;TZID=America/Vancouver:20220708T113000
DTSTAMP:20260615T235322
CREATED:20220608T212514Z
LAST-MODIFIED:20220613T050040Z
UID:22616-1657270800-1657279800@scienceinvancouver.com
SUMMARY:D.R.I.N.K.S. Vancouver
DESCRIPTION:The D.R.I.N.K.S. (Discussions Relevant to Inspiring New Knowledge and Science) social is held monthly at Mahoneys on Stamps Landing (Old Monk Mcqueens on False Creek at 601 Stamps Landing – http://mahonyandsons.com/). The purpose (if you need an excuse to stay a little later!) is to bring together faculty\, clinicians\, residents\, trainees\, staff\, entrepreneurs\, bio/pharm staff/execs/veterans\, lawyers\, VCs\, and others with common interests in biomedical/translational research & discovery/commercialization once a month to casually interact and meet new people over a beverage and/or appie. It’s also becoming a great way for people that have just moved to Vancouver to meet others in the industry. \nThis month’s event is sponsored by Aspect Biosystems.
URL:https://scienceinvancouver.com/event/d-r-i-n-k-s-vancouver-3/
LOCATION:Mahony and Sons\, 601 Stamps Landing\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220708T090000
DTEND;TZID=America/Vancouver:20220708T113000
DTSTAMP:20260615T235322
CREATED:20220608T212514Z
LAST-MODIFIED:20220608T212514Z
UID:26559-1657270800-1657279800@scienceinvancouver.com
SUMMARY:D.R.I.N.K.S. Vancouver
DESCRIPTION:The D.R.I.N.K.S. (Discussions Relevant to Inspiring New Knowledge and Science) social is held monthly at Mahoneys on Stamps Landing (Old Monk Mcqueens on False Creek at 601 Stamps Landing – http://mahonyandsons.com/). The purpose (if you need an excuse to stay a little later!) is to bring together faculty\, clinicians\, residents\, trainees\, staff\, entrepreneurs\, bio/pharm staff/execs/veterans\, lawyers\, VCs\, and others with common interests in biomedical/translational research & discovery/commercialization once a month to casually interact and meet new people over a beverage and/or appie. It’s also becoming a great way for people that have just moved to Vancouver to meet others in the industry. \nThis month’s event is sponsored by Aspect Biosystems.
URL:https://scienceinvancouver.com/event/d-r-i-n-k-s-vancouver-3-2/
LOCATION:Mahony and Sons\, 601 Stamps Landing\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220708T090000
DTEND;TZID=America/Vancouver:20220708T113000
DTSTAMP:20260615T235322
CREATED:20220608T212514Z
LAST-MODIFIED:20220608T212514Z
UID:28174-1657270800-1657279800@scienceinvancouver.com
SUMMARY:D.R.I.N.K.S. Vancouver
DESCRIPTION:The D.R.I.N.K.S. (Discussions Relevant to Inspiring New Knowledge and Science) social is held monthly at Mahoneys on Stamps Landing (Old Monk Mcqueens on False Creek at 601 Stamps Landing – http://mahonyandsons.com/). The purpose (if you need an excuse to stay a little later!) is to bring together faculty\, clinicians\, residents\, trainees\, staff\, entrepreneurs\, bio/pharm staff/execs/veterans\, lawyers\, VCs\, and others with common interests in biomedical/translational research & discovery/commercialization once a month to casually interact and meet new people over a beverage and/or appie. It’s also becoming a great way for people that have just moved to Vancouver to meet others in the industry. \nThis month’s event is sponsored by Aspect Biosystems.
URL:https://scienceinvancouver.com/event/d-r-i-n-k-s-vancouver-3-3/
LOCATION:Mahony and Sons\, 601 Stamps Landing\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220708T090000
DTEND;TZID=America/Vancouver:20220708T113000
DTSTAMP:20260615T235322
CREATED:20220608T212514Z
LAST-MODIFIED:20220608T212514Z
UID:31257-1657270800-1657279800@scienceinvancouver.com
SUMMARY:D.R.I.N.K.S. Vancouver
DESCRIPTION:The D.R.I.N.K.S. (Discussions Relevant to Inspiring New Knowledge and Science) social is held monthly at Mahoneys on Stamps Landing (Old Monk Mcqueens on False Creek at 601 Stamps Landing – http://mahonyandsons.com/). The purpose (if you need an excuse to stay a little later!) is to bring together faculty\, clinicians\, residents\, trainees\, staff\, entrepreneurs\, bio/pharm staff/execs/veterans\, lawyers\, VCs\, and others with common interests in biomedical/translational research & discovery/commercialization once a month to casually interact and meet new people over a beverage and/or appie. It’s also becoming a great way for people that have just moved to Vancouver to meet others in the industry. \nThis month’s event is sponsored by Aspect Biosystems.
URL:https://scienceinvancouver.com/event/d-r-i-n-k-s-vancouver-3-4/
LOCATION:Mahony and Sons\, 601 Stamps Landing\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220708T090000
DTEND;TZID=America/Vancouver:20220708T113000
DTSTAMP:20260615T235322
CREATED:20220608T212514Z
LAST-MODIFIED:20220608T212514Z
UID:32717-1657270800-1657279800@scienceinvancouver.com
SUMMARY:D.R.I.N.K.S. Vancouver
DESCRIPTION:The D.R.I.N.K.S. (Discussions Relevant to Inspiring New Knowledge and Science) social is held monthly at Mahoneys on Stamps Landing (Old Monk Mcqueens on False Creek at 601 Stamps Landing – http://mahonyandsons.com/). The purpose (if you need an excuse to stay a little later!) is to bring together faculty\, clinicians\, residents\, trainees\, staff\, entrepreneurs\, bio/pharm staff/execs/veterans\, lawyers\, VCs\, and others with common interests in biomedical/translational research & discovery/commercialization once a month to casually interact and meet new people over a beverage and/or appie. It’s also becoming a great way for people that have just moved to Vancouver to meet others in the industry. \nThis month’s event is sponsored by Aspect Biosystems.
URL:https://scienceinvancouver.com/event/d-r-i-n-k-s-vancouver-3-5/
LOCATION:Mahony and Sons\, 601 Stamps Landing\, Vancouver
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220713T180000
DTEND;TZID=America/Vancouver:20220713T193000
DTSTAMP:20260615T235322
CREATED:20220712T223807Z
LAST-MODIFIED:20220712T223807Z
UID:23165-1657735200-1657740600@scienceinvancouver.com
SUMMARY:STEMCELL Virtual Career Event
DESCRIPTION:Don’t just look for a job. CONNECT with the right employer. \nThis Virtual Hiring Fair will be held on Wednesday\, July 13\, 2022\, where representatives from various STEMCELL Technologies departments like Research & Development\, Sales\, Recruitment and more will be hiring. \nWhat are the Benefits? \n1. Provide seamless access to local talent and job opportunities at STEMCELL Technologies \n2. Connect professionals with job seekers so they can collaborate and support each other \n3. Provide resources to support long-lasting career growth \nWhat to expect before the Hiring fair? \n1. To help direct the discussion\, send in questions in advance \nWhat to expect at the Hiring fair? \n1. Panel Introduction and meet-and-great \n2. You will be put in breakout for each department to discuss various available positions and their job descriptions \n3. Every 15 minutes you will be rolled into the next department
URL:https://scienceinvancouver.com/event/stemcell-virtual-career-event-2/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/CR438-1100x628-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220713T180000
DTEND;TZID=America/Vancouver:20220713T193000
DTSTAMP:20260615T235322
CREATED:20220712T223807Z
LAST-MODIFIED:20220712T223807Z
UID:26573-1657735200-1657740600@scienceinvancouver.com
SUMMARY:STEMCELL Virtual Career Event
DESCRIPTION:Don’t just look for a job. CONNECT with the right employer. \nThis Virtual Hiring Fair will be held on Wednesday\, July 13\, 2022\, where representatives from various STEMCELL Technologies departments like Research & Development\, Sales\, Recruitment and more will be hiring. \nWhat are the Benefits? \n1. Provide seamless access to local talent and job opportunities at STEMCELL Technologies \n2. Connect professionals with job seekers so they can collaborate and support each other \n3. Provide resources to support long-lasting career growth \nWhat to expect before the Hiring fair? \n1. To help direct the discussion\, send in questions in advance \nWhat to expect at the Hiring fair? \n1. Panel Introduction and meet-and-great \n2. You will be put in breakout for each department to discuss various available positions and their job descriptions \n3. Every 15 minutes you will be rolled into the next department
URL:https://scienceinvancouver.com/event/stemcell-virtual-career-event-2-2/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/CR438-1100x628-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220713T180000
DTEND;TZID=America/Vancouver:20220713T193000
DTSTAMP:20260615T235322
CREATED:20220712T223807Z
LAST-MODIFIED:20220712T223807Z
UID:28188-1657735200-1657740600@scienceinvancouver.com
SUMMARY:STEMCELL Virtual Career Event
DESCRIPTION:Don’t just look for a job. CONNECT with the right employer. \nThis Virtual Hiring Fair will be held on Wednesday\, July 13\, 2022\, where representatives from various STEMCELL Technologies departments like Research & Development\, Sales\, Recruitment and more will be hiring. \nWhat are the Benefits? \n1. Provide seamless access to local talent and job opportunities at STEMCELL Technologies \n2. Connect professionals with job seekers so they can collaborate and support each other \n3. Provide resources to support long-lasting career growth \nWhat to expect before the Hiring fair? \n1. To help direct the discussion\, send in questions in advance \nWhat to expect at the Hiring fair? \n1. Panel Introduction and meet-and-great \n2. You will be put in breakout for each department to discuss various available positions and their job descriptions \n3. Every 15 minutes you will be rolled into the next department
URL:https://scienceinvancouver.com/event/stemcell-virtual-career-event-2-3/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/CR438-1100x628-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220713T180000
DTEND;TZID=America/Vancouver:20220713T193000
DTSTAMP:20260615T235322
CREATED:20220712T223807Z
LAST-MODIFIED:20220712T223807Z
UID:31271-1657735200-1657740600@scienceinvancouver.com
SUMMARY:STEMCELL Virtual Career Event
DESCRIPTION:Don’t just look for a job. CONNECT with the right employer. \nThis Virtual Hiring Fair will be held on Wednesday\, July 13\, 2022\, where representatives from various STEMCELL Technologies departments like Research & Development\, Sales\, Recruitment and more will be hiring. \nWhat are the Benefits? \n1. Provide seamless access to local talent and job opportunities at STEMCELL Technologies \n2. Connect professionals with job seekers so they can collaborate and support each other \n3. Provide resources to support long-lasting career growth \nWhat to expect before the Hiring fair? \n1. To help direct the discussion\, send in questions in advance \nWhat to expect at the Hiring fair? \n1. Panel Introduction and meet-and-great \n2. You will be put in breakout for each department to discuss various available positions and their job descriptions \n3. Every 15 minutes you will be rolled into the next department
URL:https://scienceinvancouver.com/event/stemcell-virtual-career-event-2-4/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/CR438-1100x628-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220713T180000
DTEND;TZID=America/Vancouver:20220713T193000
DTSTAMP:20260615T235322
CREATED:20220712T223807Z
LAST-MODIFIED:20220712T223807Z
UID:32731-1657735200-1657740600@scienceinvancouver.com
SUMMARY:STEMCELL Virtual Career Event
DESCRIPTION:Don’t just look for a job. CONNECT with the right employer. \nThis Virtual Hiring Fair will be held on Wednesday\, July 13\, 2022\, where representatives from various STEMCELL Technologies departments like Research & Development\, Sales\, Recruitment and more will be hiring. \nWhat are the Benefits? \n1. Provide seamless access to local talent and job opportunities at STEMCELL Technologies \n2. Connect professionals with job seekers so they can collaborate and support each other \n3. Provide resources to support long-lasting career growth \nWhat to expect before the Hiring fair? \n1. To help direct the discussion\, send in questions in advance \nWhat to expect at the Hiring fair? \n1. Panel Introduction and meet-and-great \n2. You will be put in breakout for each department to discuss various available positions and their job descriptions \n3. Every 15 minutes you will be rolled into the next department
URL:https://scienceinvancouver.com/event/stemcell-virtual-career-event-2-5/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/CR438-1100x628-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220720T050000
DTEND;TZID=America/Vancouver:20220720T063000
DTSTAMP:20260615T235322
CREATED:20220711T195113Z
LAST-MODIFIED:20220711T195531Z
UID:23144-1658293200-1658298600@scienceinvancouver.com
SUMMARY:BC Brain Wellness Program Presents World Brain Day: Brain Health for All
DESCRIPTION:On Wednesday\, July 20th\, Dr. Silke Appel-Cresswell and the BC Brain Wellness Program invite you to join our annual celebration of World Brain Day! The World Federation of Neurology has selected the theme “Brain Health for All”\, which aligns with our vision and mission at the Brain Wellness Program. \nPlease join us to learn from keynote speaker Dr. Roger Wong and his research and approaches surrounding dementia care and enjoy a special presentation from BWP Co-Founder\, Dr. Silke Appel-Cresswell on lifestyle interventions from promoting brain health for all. \nWe will also be joined by participants of the BWP who will share the impact of participating in our Intergenerational Program as well as how the BWP supports brain health for all through the lens of one of our BWP families including a participant\, a care partner\, and health ager.
URL:https://scienceinvancouver.com/event/bc-brain-wellness-program-presents-world-brain-day-brain-health-for-all/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/World-Brain-Day-2022.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220720T050000
DTEND;TZID=America/Vancouver:20220720T063000
DTSTAMP:20260615T235322
CREATED:20220711T195113Z
LAST-MODIFIED:20220711T195113Z
UID:26572-1658293200-1658298600@scienceinvancouver.com
SUMMARY:BC Brain Wellness Program Presents World Brain Day: Brain Health for All
DESCRIPTION:On Wednesday\, July 20th\, Dr. Silke Appel-Cresswell and the BC Brain Wellness Program invite you to join our annual celebration of World Brain Day! The World Federation of Neurology has selected the theme “Brain Health for All”\, which aligns with our vision and mission at the Brain Wellness Program. \nPlease join us to learn from keynote speaker Dr. Roger Wong and his research and approaches surrounding dementia care and enjoy a special presentation from BWP Co-Founder\, Dr. Silke Appel-Cresswell on lifestyle interventions from promoting brain health for all. \nWe will also be joined by participants of the BWP who will share the impact of participating in our Intergenerational Program as well as how the BWP supports brain health for all through the lens of one of our BWP families including a participant\, a care partner\, and health ager.
URL:https://scienceinvancouver.com/event/bc-brain-wellness-program-presents-world-brain-day-brain-health-for-all-2/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/World-Brain-Day-2022.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220720T050000
DTEND;TZID=America/Vancouver:20220720T063000
DTSTAMP:20260615T235322
CREATED:20220711T195113Z
LAST-MODIFIED:20220711T195113Z
UID:28187-1658293200-1658298600@scienceinvancouver.com
SUMMARY:BC Brain Wellness Program Presents World Brain Day: Brain Health for All
DESCRIPTION:On Wednesday\, July 20th\, Dr. Silke Appel-Cresswell and the BC Brain Wellness Program invite you to join our annual celebration of World Brain Day! The World Federation of Neurology has selected the theme “Brain Health for All”\, which aligns with our vision and mission at the Brain Wellness Program. \nPlease join us to learn from keynote speaker Dr. Roger Wong and his research and approaches surrounding dementia care and enjoy a special presentation from BWP Co-Founder\, Dr. Silke Appel-Cresswell on lifestyle interventions from promoting brain health for all. \nWe will also be joined by participants of the BWP who will share the impact of participating in our Intergenerational Program as well as how the BWP supports brain health for all through the lens of one of our BWP families including a participant\, a care partner\, and health ager.
URL:https://scienceinvancouver.com/event/bc-brain-wellness-program-presents-world-brain-day-brain-health-for-all-3/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/World-Brain-Day-2022.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220720T050000
DTEND;TZID=America/Vancouver:20220720T063000
DTSTAMP:20260615T235322
CREATED:20220711T195113Z
LAST-MODIFIED:20220711T195113Z
UID:31270-1658293200-1658298600@scienceinvancouver.com
SUMMARY:BC Brain Wellness Program Presents World Brain Day: Brain Health for All
DESCRIPTION:On Wednesday\, July 20th\, Dr. Silke Appel-Cresswell and the BC Brain Wellness Program invite you to join our annual celebration of World Brain Day! The World Federation of Neurology has selected the theme “Brain Health for All”\, which aligns with our vision and mission at the Brain Wellness Program. \nPlease join us to learn from keynote speaker Dr. Roger Wong and his research and approaches surrounding dementia care and enjoy a special presentation from BWP Co-Founder\, Dr. Silke Appel-Cresswell on lifestyle interventions from promoting brain health for all. \nWe will also be joined by participants of the BWP who will share the impact of participating in our Intergenerational Program as well as how the BWP supports brain health for all through the lens of one of our BWP families including a participant\, a care partner\, and health ager.
URL:https://scienceinvancouver.com/event/bc-brain-wellness-program-presents-world-brain-day-brain-health-for-all-4/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/World-Brain-Day-2022.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220720T050000
DTEND;TZID=America/Vancouver:20220720T063000
DTSTAMP:20260615T235322
CREATED:20220711T195113Z
LAST-MODIFIED:20220711T195113Z
UID:32730-1658293200-1658298600@scienceinvancouver.com
SUMMARY:BC Brain Wellness Program Presents World Brain Day: Brain Health for All
DESCRIPTION:On Wednesday\, July 20th\, Dr. Silke Appel-Cresswell and the BC Brain Wellness Program invite you to join our annual celebration of World Brain Day! The World Federation of Neurology has selected the theme “Brain Health for All”\, which aligns with our vision and mission at the Brain Wellness Program. \nPlease join us to learn from keynote speaker Dr. Roger Wong and his research and approaches surrounding dementia care and enjoy a special presentation from BWP Co-Founder\, Dr. Silke Appel-Cresswell on lifestyle interventions from promoting brain health for all. \nWe will also be joined by participants of the BWP who will share the impact of participating in our Intergenerational Program as well as how the BWP supports brain health for all through the lens of one of our BWP families including a participant\, a care partner\, and health ager.
URL:https://scienceinvancouver.com/event/bc-brain-wellness-program-presents-world-brain-day-brain-health-for-all-5/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/World-Brain-Day-2022.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220728T110000
DTEND;TZID=America/Vancouver:20220728T115500
DTSTAMP:20260615T235322
CREATED:20220725T174442Z
LAST-MODIFIED:20220725T174442Z
UID:23347-1659006000-1659009300@scienceinvancouver.com
SUMMARY:Research Lecture: Wen Li
DESCRIPTION:SBME\, UBC ECE\, and the Bionics Network present:\nTalk: Miniaturized\, Hybrid Opto-Electro-Chemo Neuroprosthetic Devices\nOverview:Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular\, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative microdevices based on multiple modalities (e.g. electrical\, optical\, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research\, biomedical diagnostics\, and therapeutics. This talk will focus on our recent efforts toward developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. In the first part of this talk\, I will showcase our development of optoelectronics devices consisting of microscale light emitting diodes and transparent microelectrodes\, capable of optogenetic modulation and electrical recording of neural activity. Also highlighted is an ultra-flexible\, highly conductive and transparent microscale electrocorticogram electrode array made of PEDOT:PSS-ITO-Ag-ITO assembly. The second part of this talk will focus on our recent development of boron-doped polycrystalline diamond electrodes for neurotransmitter sensing using a fast scan cyclic voltammetry method. The in-vitro or in-vivo study to validate the efficacy of the above devices will also be discussed.
URL:https://scienceinvancouver.com/event/research-lecture-wen-li/
LOCATION:Life Sciences Centre & Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/SBME-seminar-Wen-Li-2022.07.28.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220728T110000
DTEND;TZID=America/Vancouver:20220728T115500
DTSTAMP:20260615T235322
CREATED:20220725T174442Z
LAST-MODIFIED:20220725T174442Z
UID:26577-1659006000-1659009300@scienceinvancouver.com
SUMMARY:Research Lecture: Wen Li
DESCRIPTION:SBME\, UBC ECE\, and the Bionics Network present:\nTalk: Miniaturized\, Hybrid Opto-Electro-Chemo Neuroprosthetic Devices\nOverview:Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular\, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative microdevices based on multiple modalities (e.g. electrical\, optical\, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research\, biomedical diagnostics\, and therapeutics. This talk will focus on our recent efforts toward developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. In the first part of this talk\, I will showcase our development of optoelectronics devices consisting of microscale light emitting diodes and transparent microelectrodes\, capable of optogenetic modulation and electrical recording of neural activity. Also highlighted is an ultra-flexible\, highly conductive and transparent microscale electrocorticogram electrode array made of PEDOT:PSS-ITO-Ag-ITO assembly. The second part of this talk will focus on our recent development of boron-doped polycrystalline diamond electrodes for neurotransmitter sensing using a fast scan cyclic voltammetry method. The in-vitro or in-vivo study to validate the efficacy of the above devices will also be discussed.
URL:https://scienceinvancouver.com/event/research-lecture-wen-li-2/
LOCATION:Life Sciences Centre & Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/SBME-seminar-Wen-Li-2022.07.28.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220728T110000
DTEND;TZID=America/Vancouver:20220728T115500
DTSTAMP:20260615T235322
CREATED:20220725T174442Z
LAST-MODIFIED:20220725T174442Z
UID:28192-1659006000-1659009300@scienceinvancouver.com
SUMMARY:Research Lecture: Wen Li
DESCRIPTION:SBME\, UBC ECE\, and the Bionics Network present:\nTalk: Miniaturized\, Hybrid Opto-Electro-Chemo Neuroprosthetic Devices\nOverview:Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular\, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative microdevices based on multiple modalities (e.g. electrical\, optical\, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research\, biomedical diagnostics\, and therapeutics. This talk will focus on our recent efforts toward developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. In the first part of this talk\, I will showcase our development of optoelectronics devices consisting of microscale light emitting diodes and transparent microelectrodes\, capable of optogenetic modulation and electrical recording of neural activity. Also highlighted is an ultra-flexible\, highly conductive and transparent microscale electrocorticogram electrode array made of PEDOT:PSS-ITO-Ag-ITO assembly. The second part of this talk will focus on our recent development of boron-doped polycrystalline diamond electrodes for neurotransmitter sensing using a fast scan cyclic voltammetry method. The in-vitro or in-vivo study to validate the efficacy of the above devices will also be discussed.
URL:https://scienceinvancouver.com/event/research-lecture-wen-li-3/
LOCATION:Life Sciences Centre & Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/SBME-seminar-Wen-Li-2022.07.28.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220728T110000
DTEND;TZID=America/Vancouver:20220728T115500
DTSTAMP:20260615T235322
CREATED:20220725T174442Z
LAST-MODIFIED:20220725T174442Z
UID:31275-1659006000-1659009300@scienceinvancouver.com
SUMMARY:Research Lecture: Wen Li
DESCRIPTION:SBME\, UBC ECE\, and the Bionics Network present:\nTalk: Miniaturized\, Hybrid Opto-Electro-Chemo Neuroprosthetic Devices\nOverview:Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular\, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative microdevices based on multiple modalities (e.g. electrical\, optical\, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research\, biomedical diagnostics\, and therapeutics. This talk will focus on our recent efforts toward developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. In the first part of this talk\, I will showcase our development of optoelectronics devices consisting of microscale light emitting diodes and transparent microelectrodes\, capable of optogenetic modulation and electrical recording of neural activity. Also highlighted is an ultra-flexible\, highly conductive and transparent microscale electrocorticogram electrode array made of PEDOT:PSS-ITO-Ag-ITO assembly. The second part of this talk will focus on our recent development of boron-doped polycrystalline diamond electrodes for neurotransmitter sensing using a fast scan cyclic voltammetry method. The in-vitro or in-vivo study to validate the efficacy of the above devices will also be discussed.
URL:https://scienceinvancouver.com/event/research-lecture-wen-li-4/
LOCATION:Life Sciences Centre & Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/SBME-seminar-Wen-Li-2022.07.28.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220728T110000
DTEND;TZID=America/Vancouver:20220728T115500
DTSTAMP:20260615T235322
CREATED:20220725T174442Z
LAST-MODIFIED:20220725T174442Z
UID:32735-1659006000-1659009300@scienceinvancouver.com
SUMMARY:Research Lecture: Wen Li
DESCRIPTION:SBME\, UBC ECE\, and the Bionics Network present:\nTalk: Miniaturized\, Hybrid Opto-Electro-Chemo Neuroprosthetic Devices\nOverview:Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular\, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative microdevices based on multiple modalities (e.g. electrical\, optical\, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research\, biomedical diagnostics\, and therapeutics. This talk will focus on our recent efforts toward developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. In the first part of this talk\, I will showcase our development of optoelectronics devices consisting of microscale light emitting diodes and transparent microelectrodes\, capable of optogenetic modulation and electrical recording of neural activity. Also highlighted is an ultra-flexible\, highly conductive and transparent microscale electrocorticogram electrode array made of PEDOT:PSS-ITO-Ag-ITO assembly. The second part of this talk will focus on our recent development of boron-doped polycrystalline diamond electrodes for neurotransmitter sensing using a fast scan cyclic voltammetry method. The in-vitro or in-vivo study to validate the efficacy of the above devices will also be discussed.
URL:https://scienceinvancouver.com/event/research-lecture-wen-li-5/
LOCATION:Life Sciences Centre & Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2022/07/SBME-seminar-Wen-Li-2022.07.28.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220729T120000
DTEND;TZID=America/Vancouver:20220729T130000
DTSTAMP:20260615T235322
CREATED:20220713T164118Z
LAST-MODIFIED:20220726T003224Z
UID:23169-1659096000-1659099600@scienceinvancouver.com
SUMMARY:Development & Utilization of In Vivo Systems to Optimize Lipid Nanoparticles for Therapeutic Genome Editing
DESCRIPTION:Genetic diseases are a leading cause of death and disability in Canada with immense economic and societal burdens. Gene therapy has emerged as a means to effectively treat genetic diseases; however\, current gene therapies are limited by their high manufacturing costs\, the inability to re-dose\, and the safety concerns of some viral vectors. \nCRISPR genome editing is a new therapeutic approach that aims to directly repair the underlying disease-causing mutations. Conventional CRISPR methods are limited as in vivo therapeutics because they introduce DNA breaks and cause frequent off-target edits. Newer base editors and prime editors overcome the limitations traditional CRISPR genome editing methods because they do not introduce DNA breaks. \nHowever\, the delivery of genome editors to affected tissues remains a challenge. Viral vectors\, such as AAV\, are unsuitable for genome editing because their long expression (years) increases the probability of unintended edits. In contrast\, the transient expression (hours-days) of RNA encoding genome editors via nanoparticles is well suited for genome editing\, and unlike viral vectors\, nanoparticles can be readministered. However\, nanoparticle delivery of complex genome editing cargos (large mRNA + small gRNA) remains a challenge\, especially to extra-hepatic target tissues such as muscle. To address this\, we are developing new ways to safely deliver these new editors using lipid nanoparticles. \nTo efficiently measure the in vivo effectiveness of genome editor delivery via LNPs\, we have developed transgenic mice that carry mutations in reporter genes. Precise gene repair of these mutations produce a functional enzyme that emits light (luminescence) that sensitive imagers can detect to precisely measure the location and extent of gene editing in living animals. We have made progress in our goal towards efficient and safe in vivo genome editing that we will share. \n\n\n\n\n\n\nDr. Colin Ross seeks to incorporate genomics into guiding\, optimising\, and developing novel therapeutics to improve the safety and effectiveness of medications. His research is also exploring the use of genome sequencing to help diagnose and manage the treatment of rare genetic diseases.
URL:https://scienceinvancouver.com/event/development-utilization-of-in-vivo-systems-to-optimize-lipid-nanoparticles-for-therapeutic-genome-editing/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220729T120000
DTEND;TZID=America/Vancouver:20220729T130000
DTSTAMP:20260615T235322
CREATED:20220713T164118Z
LAST-MODIFIED:20220713T164118Z
UID:26574-1659096000-1659099600@scienceinvancouver.com
SUMMARY:Development & Utilization of In Vivo Systems to Optimize Lipid Nanoparticles for Therapeutic Genome Editing
DESCRIPTION:Genetic diseases are a leading cause of death and disability in Canada with immense economic and societal burdens. Gene therapy has emerged as a means to effectively treat genetic diseases; however\, current gene therapies are limited by their high manufacturing costs\, the inability to re-dose\, and the safety concerns of some viral vectors. \nCRISPR genome editing is a new therapeutic approach that aims to directly repair the underlying disease-causing mutations. Conventional CRISPR methods are limited as in vivo therapeutics because they introduce DNA breaks and cause frequent off-target edits. Newer base editors and prime editors overcome the limitations traditional CRISPR genome editing methods because they do not introduce DNA breaks. \nHowever\, the delivery of genome editors to affected tissues remains a challenge. Viral vectors\, such as AAV\, are unsuitable for genome editing because their long expression (years) increases the probability of unintended edits. In contrast\, the transient expression (hours-days) of RNA encoding genome editors via nanoparticles is well suited for genome editing\, and unlike viral vectors\, nanoparticles can be readministered. However\, nanoparticle delivery of complex genome editing cargos (large mRNA + small gRNA) remains a challenge\, especially to extra-hepatic target tissues such as muscle. To address this\, we are developing new ways to safely deliver these new editors using lipid nanoparticles. \nTo efficiently measure the in vivo effectiveness of genome editor delivery via LNPs\, we have developed transgenic mice that carry mutations in reporter genes. Precise gene repair of these mutations produce a functional enzyme that emits light (luminescence) that sensitive imagers can detect to precisely measure the location and extent of gene editing in living animals. We have made progress in our goal towards efficient and safe in vivo genome editing that we will share. \n\n\n\n\n\n\nDr. Colin Ross seeks to incorporate genomics into guiding\, optimising\, and developing novel therapeutics to improve the safety and effectiveness of medications. His research is also exploring the use of genome sequencing to help diagnose and manage the treatment of rare genetic diseases.
URL:https://scienceinvancouver.com/event/development-utilization-of-in-vivo-systems-to-optimize-lipid-nanoparticles-for-therapeutic-genome-editing-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220729T120000
DTEND;TZID=America/Vancouver:20220729T130000
DTSTAMP:20260615T235322
CREATED:20220713T164118Z
LAST-MODIFIED:20220713T164118Z
UID:28189-1659096000-1659099600@scienceinvancouver.com
SUMMARY:Development & Utilization of In Vivo Systems to Optimize Lipid Nanoparticles for Therapeutic Genome Editing
DESCRIPTION:Genetic diseases are a leading cause of death and disability in Canada with immense economic and societal burdens. Gene therapy has emerged as a means to effectively treat genetic diseases; however\, current gene therapies are limited by their high manufacturing costs\, the inability to re-dose\, and the safety concerns of some viral vectors. \nCRISPR genome editing is a new therapeutic approach that aims to directly repair the underlying disease-causing mutations. Conventional CRISPR methods are limited as in vivo therapeutics because they introduce DNA breaks and cause frequent off-target edits. Newer base editors and prime editors overcome the limitations traditional CRISPR genome editing methods because they do not introduce DNA breaks. \nHowever\, the delivery of genome editors to affected tissues remains a challenge. Viral vectors\, such as AAV\, are unsuitable for genome editing because their long expression (years) increases the probability of unintended edits. In contrast\, the transient expression (hours-days) of RNA encoding genome editors via nanoparticles is well suited for genome editing\, and unlike viral vectors\, nanoparticles can be readministered. However\, nanoparticle delivery of complex genome editing cargos (large mRNA + small gRNA) remains a challenge\, especially to extra-hepatic target tissues such as muscle. To address this\, we are developing new ways to safely deliver these new editors using lipid nanoparticles. \nTo efficiently measure the in vivo effectiveness of genome editor delivery via LNPs\, we have developed transgenic mice that carry mutations in reporter genes. Precise gene repair of these mutations produce a functional enzyme that emits light (luminescence) that sensitive imagers can detect to precisely measure the location and extent of gene editing in living animals. We have made progress in our goal towards efficient and safe in vivo genome editing that we will share. \n\n\n\n\n\n\nDr. Colin Ross seeks to incorporate genomics into guiding\, optimising\, and developing novel therapeutics to improve the safety and effectiveness of medications. His research is also exploring the use of genome sequencing to help diagnose and manage the treatment of rare genetic diseases.
URL:https://scienceinvancouver.com/event/development-utilization-of-in-vivo-systems-to-optimize-lipid-nanoparticles-for-therapeutic-genome-editing-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220729T120000
DTEND;TZID=America/Vancouver:20220729T130000
DTSTAMP:20260615T235322
CREATED:20220713T164118Z
LAST-MODIFIED:20220713T164118Z
UID:31272-1659096000-1659099600@scienceinvancouver.com
SUMMARY:Development & Utilization of In Vivo Systems to Optimize Lipid Nanoparticles for Therapeutic Genome Editing
DESCRIPTION:Genetic diseases are a leading cause of death and disability in Canada with immense economic and societal burdens. Gene therapy has emerged as a means to effectively treat genetic diseases; however\, current gene therapies are limited by their high manufacturing costs\, the inability to re-dose\, and the safety concerns of some viral vectors. \nCRISPR genome editing is a new therapeutic approach that aims to directly repair the underlying disease-causing mutations. Conventional CRISPR methods are limited as in vivo therapeutics because they introduce DNA breaks and cause frequent off-target edits. Newer base editors and prime editors overcome the limitations traditional CRISPR genome editing methods because they do not introduce DNA breaks. \nHowever\, the delivery of genome editors to affected tissues remains a challenge. Viral vectors\, such as AAV\, are unsuitable for genome editing because their long expression (years) increases the probability of unintended edits. In contrast\, the transient expression (hours-days) of RNA encoding genome editors via nanoparticles is well suited for genome editing\, and unlike viral vectors\, nanoparticles can be readministered. However\, nanoparticle delivery of complex genome editing cargos (large mRNA + small gRNA) remains a challenge\, especially to extra-hepatic target tissues such as muscle. To address this\, we are developing new ways to safely deliver these new editors using lipid nanoparticles. \nTo efficiently measure the in vivo effectiveness of genome editor delivery via LNPs\, we have developed transgenic mice that carry mutations in reporter genes. Precise gene repair of these mutations produce a functional enzyme that emits light (luminescence) that sensitive imagers can detect to precisely measure the location and extent of gene editing in living animals. We have made progress in our goal towards efficient and safe in vivo genome editing that we will share. \n\n\n\n\n\n\nDr. Colin Ross seeks to incorporate genomics into guiding\, optimising\, and developing novel therapeutics to improve the safety and effectiveness of medications. His research is also exploring the use of genome sequencing to help diagnose and manage the treatment of rare genetic diseases.
URL:https://scienceinvancouver.com/event/development-utilization-of-in-vivo-systems-to-optimize-lipid-nanoparticles-for-therapeutic-genome-editing-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20220729T120000
DTEND;TZID=America/Vancouver:20220729T130000
DTSTAMP:20260615T235322
CREATED:20220713T164118Z
LAST-MODIFIED:20220713T164118Z
UID:32732-1659096000-1659099600@scienceinvancouver.com
SUMMARY:Development & Utilization of In Vivo Systems to Optimize Lipid Nanoparticles for Therapeutic Genome Editing
DESCRIPTION:Genetic diseases are a leading cause of death and disability in Canada with immense economic and societal burdens. Gene therapy has emerged as a means to effectively treat genetic diseases; however\, current gene therapies are limited by their high manufacturing costs\, the inability to re-dose\, and the safety concerns of some viral vectors. \nCRISPR genome editing is a new therapeutic approach that aims to directly repair the underlying disease-causing mutations. Conventional CRISPR methods are limited as in vivo therapeutics because they introduce DNA breaks and cause frequent off-target edits. Newer base editors and prime editors overcome the limitations traditional CRISPR genome editing methods because they do not introduce DNA breaks. \nHowever\, the delivery of genome editors to affected tissues remains a challenge. Viral vectors\, such as AAV\, are unsuitable for genome editing because their long expression (years) increases the probability of unintended edits. In contrast\, the transient expression (hours-days) of RNA encoding genome editors via nanoparticles is well suited for genome editing\, and unlike viral vectors\, nanoparticles can be readministered. However\, nanoparticle delivery of complex genome editing cargos (large mRNA + small gRNA) remains a challenge\, especially to extra-hepatic target tissues such as muscle. To address this\, we are developing new ways to safely deliver these new editors using lipid nanoparticles. \nTo efficiently measure the in vivo effectiveness of genome editor delivery via LNPs\, we have developed transgenic mice that carry mutations in reporter genes. Precise gene repair of these mutations produce a functional enzyme that emits light (luminescence) that sensitive imagers can detect to precisely measure the location and extent of gene editing in living animals. We have made progress in our goal towards efficient and safe in vivo genome editing that we will share. \n\n\n\n\n\n\nDr. Colin Ross seeks to incorporate genomics into guiding\, optimising\, and developing novel therapeutics to improve the safety and effectiveness of medications. His research is also exploring the use of genome sequencing to help diagnose and manage the treatment of rare genetic diseases.
URL:https://scienceinvancouver.com/event/development-utilization-of-in-vivo-systems-to-optimize-lipid-nanoparticles-for-therapeutic-genome-editing-5/
LOCATION:Online
END:VEVENT
END:VCALENDAR