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DTSTART;TZID=America/Vancouver:20200610T140000
DTEND;TZID=America/Vancouver:20200610T170000
DTSTAMP:20260404T184923
CREATED:20200526T153905Z
LAST-MODIFIED:20200526T153905Z
UID:11458-1591797600-1591808400@scienceinvancouver.com
SUMMARY:2020 Youth Innovation Showcase Finals
DESCRIPTION:Welcome to the 2020 (VIRTUAL) Youth Innovation Showcase Competition! From callout to closing\, the competition has been fierce. Youth from across the province and Yukon have been hard at work these last few months polishing their innovative ideas and prototypes. Our panel of industry experts spent countless hours reviewing each and every submission\, and we’re excited to finally announce the finalists who will continue on in the competition at this year’s event! \nJoin us online on June 10th as the finalists in each age category pitch live to a panel of industry judges and an audience support of family\, friends\, industry and investors from across the province and beyond. \nEach finalist will have 2 minutes to pitch their idea\, followed by 3 minutes of Q & A by the judges to learn more about their innovation idea. At the completion of each category\, the judges will tally their scores\, and award the winning innovation $5\,000. \nLogin details to view the competition to be provided closer to the date. \nGet to know these inspiring\, young innovators! \nAGENDA \n2:00pm – Finals for the 12 to 15 Age Category \n3:00pm – Finals for the 16 to 19 Age Category \n3:45pm – Finals for the 20 to 24 Age Category \nMark your calendars and register to attend this virtual competition. The future of innovation in British Columbia and the Yukon\, never looked brighter! Show your support today! \nShare us forward @youthinnovationshowcase #YIS2020
URL:https://scienceinvancouver.com/event/2020-youth-innovation-showcase-finals/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/05/2020-Youth-Innovation-Showcase-Finals.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200610T140000
DTEND;TZID=America/Vancouver:20200610T170000
DTSTAMP:20260404T184923
CREATED:20200526T153905Z
LAST-MODIFIED:20200526T153905Z
UID:26174-1591797600-1591808400@scienceinvancouver.com
SUMMARY:2020 Youth Innovation Showcase Finals
DESCRIPTION:Welcome to the 2020 (VIRTUAL) Youth Innovation Showcase Competition! From callout to closing\, the competition has been fierce. Youth from across the province and Yukon have been hard at work these last few months polishing their innovative ideas and prototypes. Our panel of industry experts spent countless hours reviewing each and every submission\, and we’re excited to finally announce the finalists who will continue on in the competition at this year’s event! \nJoin us online on June 10th as the finalists in each age category pitch live to a panel of industry judges and an audience support of family\, friends\, industry and investors from across the province and beyond. \nEach finalist will have 2 minutes to pitch their idea\, followed by 3 minutes of Q & A by the judges to learn more about their innovation idea. At the completion of each category\, the judges will tally their scores\, and award the winning innovation $5\,000. \nLogin details to view the competition to be provided closer to the date. \nGet to know these inspiring\, young innovators! \nAGENDA \n2:00pm – Finals for the 12 to 15 Age Category \n3:00pm – Finals for the 16 to 19 Age Category \n3:45pm – Finals for the 20 to 24 Age Category \nMark your calendars and register to attend this virtual competition. The future of innovation in British Columbia and the Yukon\, never looked brighter! Show your support today! \nShare us forward @youthinnovationshowcase #YIS2020
URL:https://scienceinvancouver.com/event/2020-youth-innovation-showcase-finals-2/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/05/2020-Youth-Innovation-Showcase-Finals.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200610T140000
DTEND;TZID=America/Vancouver:20200610T170000
DTSTAMP:20260404T184923
CREATED:20200526T153905Z
LAST-MODIFIED:20200526T153905Z
UID:27789-1591797600-1591808400@scienceinvancouver.com
SUMMARY:2020 Youth Innovation Showcase Finals
DESCRIPTION:Welcome to the 2020 (VIRTUAL) Youth Innovation Showcase Competition! From callout to closing\, the competition has been fierce. Youth from across the province and Yukon have been hard at work these last few months polishing their innovative ideas and prototypes. Our panel of industry experts spent countless hours reviewing each and every submission\, and we’re excited to finally announce the finalists who will continue on in the competition at this year’s event! \nJoin us online on June 10th as the finalists in each age category pitch live to a panel of industry judges and an audience support of family\, friends\, industry and investors from across the province and beyond. \nEach finalist will have 2 minutes to pitch their idea\, followed by 3 minutes of Q & A by the judges to learn more about their innovation idea. At the completion of each category\, the judges will tally their scores\, and award the winning innovation $5\,000. \nLogin details to view the competition to be provided closer to the date. \nGet to know these inspiring\, young innovators! \nAGENDA \n2:00pm – Finals for the 12 to 15 Age Category \n3:00pm – Finals for the 16 to 19 Age Category \n3:45pm – Finals for the 20 to 24 Age Category \nMark your calendars and register to attend this virtual competition. The future of innovation in British Columbia and the Yukon\, never looked brighter! Show your support today! \nShare us forward @youthinnovationshowcase #YIS2020
URL:https://scienceinvancouver.com/event/2020-youth-innovation-showcase-finals-3/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/05/2020-Youth-Innovation-Showcase-Finals.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200610T140000
DTEND;TZID=America/Vancouver:20200610T170000
DTSTAMP:20260404T184923
CREATED:20200526T153905Z
LAST-MODIFIED:20200526T153905Z
UID:30872-1591797600-1591808400@scienceinvancouver.com
SUMMARY:2020 Youth Innovation Showcase Finals
DESCRIPTION:Welcome to the 2020 (VIRTUAL) Youth Innovation Showcase Competition! From callout to closing\, the competition has been fierce. Youth from across the province and Yukon have been hard at work these last few months polishing their innovative ideas and prototypes. Our panel of industry experts spent countless hours reviewing each and every submission\, and we’re excited to finally announce the finalists who will continue on in the competition at this year’s event! \nJoin us online on June 10th as the finalists in each age category pitch live to a panel of industry judges and an audience support of family\, friends\, industry and investors from across the province and beyond. \nEach finalist will have 2 minutes to pitch their idea\, followed by 3 minutes of Q & A by the judges to learn more about their innovation idea. At the completion of each category\, the judges will tally their scores\, and award the winning innovation $5\,000. \nLogin details to view the competition to be provided closer to the date. \nGet to know these inspiring\, young innovators! \nAGENDA \n2:00pm – Finals for the 12 to 15 Age Category \n3:00pm – Finals for the 16 to 19 Age Category \n3:45pm – Finals for the 20 to 24 Age Category \nMark your calendars and register to attend this virtual competition. The future of innovation in British Columbia and the Yukon\, never looked brighter! Show your support today! \nShare us forward @youthinnovationshowcase #YIS2020
URL:https://scienceinvancouver.com/event/2020-youth-innovation-showcase-finals-4/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/05/2020-Youth-Innovation-Showcase-Finals.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200610T140000
DTEND;TZID=America/Vancouver:20200610T170000
DTSTAMP:20260404T184923
CREATED:20200526T153905Z
LAST-MODIFIED:20200526T153905Z
UID:32332-1591797600-1591808400@scienceinvancouver.com
SUMMARY:2020 Youth Innovation Showcase Finals
DESCRIPTION:Welcome to the 2020 (VIRTUAL) Youth Innovation Showcase Competition! From callout to closing\, the competition has been fierce. Youth from across the province and Yukon have been hard at work these last few months polishing their innovative ideas and prototypes. Our panel of industry experts spent countless hours reviewing each and every submission\, and we’re excited to finally announce the finalists who will continue on in the competition at this year’s event! \nJoin us online on June 10th as the finalists in each age category pitch live to a panel of industry judges and an audience support of family\, friends\, industry and investors from across the province and beyond. \nEach finalist will have 2 minutes to pitch their idea\, followed by 3 minutes of Q & A by the judges to learn more about their innovation idea. At the completion of each category\, the judges will tally their scores\, and award the winning innovation $5\,000. \nLogin details to view the competition to be provided closer to the date. \nGet to know these inspiring\, young innovators! \nAGENDA \n2:00pm – Finals for the 12 to 15 Age Category \n3:00pm – Finals for the 16 to 19 Age Category \n3:45pm – Finals for the 20 to 24 Age Category \nMark your calendars and register to attend this virtual competition. The future of innovation in British Columbia and the Yukon\, never looked brighter! Show your support today! \nShare us forward @youthinnovationshowcase #YIS2020
URL:https://scienceinvancouver.com/event/2020-youth-innovation-showcase-finals-5/
LOCATION:Online
ATTACH;FMTTYPE=image/jpeg:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/05/2020-Youth-Innovation-Showcase-Finals.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200611T124500
DTEND;TZID=America/Vancouver:20200611T131500
DTSTAMP:20260404T184923
CREATED:20200608T210610Z
LAST-MODIFIED:20200608T210610Z
UID:11654-1591879500-1591881300@scienceinvancouver.com
SUMMARY:Connect with Canada LIVE
DESCRIPTION:Join BIOTECanada as we welcome to a virtual stage The Honourable Minister Navdeep Bains coinciding with BIO Digital. \nNotable thought leaders including Nadine Beauger (IRICoR) and Gordon McCauley (adMare BioInnovations). \nModerated by Andrew Casey\, BIOTECanada \nTogether they will explore: \n-Canadian innovation in the face of COVID-19 \n-Building for post COVID-19 world \n-The role Canada’s biotech industry will play in driving economic recovery and growth \nA fantastic opportunity to get in on the conversation. \nSession will be conducted via Zoom. Webinar join link will be sent in your registration confirmation email\, and then once again 1 hour before session begins.
URL:https://scienceinvancouver.com/event/connect-with-canada-live/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200611T124500
DTEND;TZID=America/Vancouver:20200611T131500
DTSTAMP:20260404T184923
CREATED:20200608T210610Z
LAST-MODIFIED:20200608T210610Z
UID:26187-1591879500-1591881300@scienceinvancouver.com
SUMMARY:Connect with Canada LIVE
DESCRIPTION:Join BIOTECanada as we welcome to a virtual stage The Honourable Minister Navdeep Bains coinciding with BIO Digital. \nNotable thought leaders including Nadine Beauger (IRICoR) and Gordon McCauley (adMare BioInnovations). \nModerated by Andrew Casey\, BIOTECanada \nTogether they will explore: \n-Canadian innovation in the face of COVID-19 \n-Building for post COVID-19 world \n-The role Canada’s biotech industry will play in driving economic recovery and growth \nA fantastic opportunity to get in on the conversation. \nSession will be conducted via Zoom. Webinar join link will be sent in your registration confirmation email\, and then once again 1 hour before session begins.
URL:https://scienceinvancouver.com/event/connect-with-canada-live-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200611T124500
DTEND;TZID=America/Vancouver:20200611T131500
DTSTAMP:20260404T184923
CREATED:20200608T210610Z
LAST-MODIFIED:20200608T210610Z
UID:27802-1591879500-1591881300@scienceinvancouver.com
SUMMARY:Connect with Canada LIVE
DESCRIPTION:Join BIOTECanada as we welcome to a virtual stage The Honourable Minister Navdeep Bains coinciding with BIO Digital. \nNotable thought leaders including Nadine Beauger (IRICoR) and Gordon McCauley (adMare BioInnovations). \nModerated by Andrew Casey\, BIOTECanada \nTogether they will explore: \n-Canadian innovation in the face of COVID-19 \n-Building for post COVID-19 world \n-The role Canada’s biotech industry will play in driving economic recovery and growth \nA fantastic opportunity to get in on the conversation. \nSession will be conducted via Zoom. Webinar join link will be sent in your registration confirmation email\, and then once again 1 hour before session begins.
URL:https://scienceinvancouver.com/event/connect-with-canada-live-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200611T124500
DTEND;TZID=America/Vancouver:20200611T131500
DTSTAMP:20260404T184923
CREATED:20200608T210610Z
LAST-MODIFIED:20200608T210610Z
UID:30885-1591879500-1591881300@scienceinvancouver.com
SUMMARY:Connect with Canada LIVE
DESCRIPTION:Join BIOTECanada as we welcome to a virtual stage The Honourable Minister Navdeep Bains coinciding with BIO Digital. \nNotable thought leaders including Nadine Beauger (IRICoR) and Gordon McCauley (adMare BioInnovations). \nModerated by Andrew Casey\, BIOTECanada \nTogether they will explore: \n-Canadian innovation in the face of COVID-19 \n-Building for post COVID-19 world \n-The role Canada’s biotech industry will play in driving economic recovery and growth \nA fantastic opportunity to get in on the conversation. \nSession will be conducted via Zoom. Webinar join link will be sent in your registration confirmation email\, and then once again 1 hour before session begins.
URL:https://scienceinvancouver.com/event/connect-with-canada-live-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200611T124500
DTEND;TZID=America/Vancouver:20200611T131500
DTSTAMP:20260404T184923
CREATED:20200608T210610Z
LAST-MODIFIED:20200608T210610Z
UID:32345-1591879500-1591881300@scienceinvancouver.com
SUMMARY:Connect with Canada LIVE
DESCRIPTION:Join BIOTECanada as we welcome to a virtual stage The Honourable Minister Navdeep Bains coinciding with BIO Digital. \nNotable thought leaders including Nadine Beauger (IRICoR) and Gordon McCauley (adMare BioInnovations). \nModerated by Andrew Casey\, BIOTECanada \nTogether they will explore: \n-Canadian innovation in the face of COVID-19 \n-Building for post COVID-19 world \n-The role Canada’s biotech industry will play in driving economic recovery and growth \nA fantastic opportunity to get in on the conversation. \nSession will be conducted via Zoom. Webinar join link will be sent in your registration confirmation email\, and then once again 1 hour before session begins.
URL:https://scienceinvancouver.com/event/connect-with-canada-live-5/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200612T110000
DTEND;TZID=America/Vancouver:20200612T120000
DTSTAMP:20260404T184923
CREATED:20200608T171102Z
LAST-MODIFIED:20200608T171102Z
UID:11644-1591959600-1591963200@scienceinvancouver.com
SUMMARY:Zoom Talk: Movement Disorders Group
DESCRIPTION:This talk is being presented by the DMCBH movement disorders group. \nVesna Sossi will discuss new insights into Parkinson’s disease coming from novel analysis methods applied to PET and multimodality imaging such as network analysis applied to neurotransmitter PET\, outcomes from multitracer PET and brain energetics with PET/MR. \nJon Stoessl will talk about tau/progression\, segregation of function and COVID-19 as a risk factor for PD. \nMartin McKeown will cover patient video monitoring\, Deep Learning and Electrical Vestibular Stimulation\, myelin imaging in PD\, and fMRI motion correction\, data fusion\, and brainstem activation. \nSilke Cresswell will discuss the role of the microbiome in PD/neurodegenerative disorders\, prevention strategies of PD/neurodegenerative disorders and the BC Brain Wellness Program. She will also discuss clinical/fundamental research integration. \n  \nTo join via Zoom\, please access the link here.
URL:https://scienceinvancouver.com/event/zoom-talk-movement-disorders-group/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200612T110000
DTEND;TZID=America/Vancouver:20200612T120000
DTSTAMP:20260404T184923
CREATED:20200608T171102Z
LAST-MODIFIED:20200608T171102Z
UID:26183-1591959600-1591963200@scienceinvancouver.com
SUMMARY:Zoom Talk: Movement Disorders Group
DESCRIPTION:This talk is being presented by the DMCBH movement disorders group. \nVesna Sossi will discuss new insights into Parkinson’s disease coming from novel analysis methods applied to PET and multimodality imaging such as network analysis applied to neurotransmitter PET\, outcomes from multitracer PET and brain energetics with PET/MR. \nJon Stoessl will talk about tau/progression\, segregation of function and COVID-19 as a risk factor for PD. \nMartin McKeown will cover patient video monitoring\, Deep Learning and Electrical Vestibular Stimulation\, myelin imaging in PD\, and fMRI motion correction\, data fusion\, and brainstem activation. \nSilke Cresswell will discuss the role of the microbiome in PD/neurodegenerative disorders\, prevention strategies of PD/neurodegenerative disorders and the BC Brain Wellness Program. She will also discuss clinical/fundamental research integration. \n  \nTo join via Zoom\, please access the link here.
URL:https://scienceinvancouver.com/event/zoom-talk-movement-disorders-group-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200612T110000
DTEND;TZID=America/Vancouver:20200612T120000
DTSTAMP:20260404T184923
CREATED:20200608T171102Z
LAST-MODIFIED:20200608T171102Z
UID:27798-1591959600-1591963200@scienceinvancouver.com
SUMMARY:Zoom Talk: Movement Disorders Group
DESCRIPTION:This talk is being presented by the DMCBH movement disorders group. \nVesna Sossi will discuss new insights into Parkinson’s disease coming from novel analysis methods applied to PET and multimodality imaging such as network analysis applied to neurotransmitter PET\, outcomes from multitracer PET and brain energetics with PET/MR. \nJon Stoessl will talk about tau/progression\, segregation of function and COVID-19 as a risk factor for PD. \nMartin McKeown will cover patient video monitoring\, Deep Learning and Electrical Vestibular Stimulation\, myelin imaging in PD\, and fMRI motion correction\, data fusion\, and brainstem activation. \nSilke Cresswell will discuss the role of the microbiome in PD/neurodegenerative disorders\, prevention strategies of PD/neurodegenerative disorders and the BC Brain Wellness Program. She will also discuss clinical/fundamental research integration. \n  \nTo join via Zoom\, please access the link here.
URL:https://scienceinvancouver.com/event/zoom-talk-movement-disorders-group-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200612T110000
DTEND;TZID=America/Vancouver:20200612T120000
DTSTAMP:20260404T184923
CREATED:20200608T171102Z
LAST-MODIFIED:20200608T171102Z
UID:30881-1591959600-1591963200@scienceinvancouver.com
SUMMARY:Zoom Talk: Movement Disorders Group
DESCRIPTION:This talk is being presented by the DMCBH movement disorders group. \nVesna Sossi will discuss new insights into Parkinson’s disease coming from novel analysis methods applied to PET and multimodality imaging such as network analysis applied to neurotransmitter PET\, outcomes from multitracer PET and brain energetics with PET/MR. \nJon Stoessl will talk about tau/progression\, segregation of function and COVID-19 as a risk factor for PD. \nMartin McKeown will cover patient video monitoring\, Deep Learning and Electrical Vestibular Stimulation\, myelin imaging in PD\, and fMRI motion correction\, data fusion\, and brainstem activation. \nSilke Cresswell will discuss the role of the microbiome in PD/neurodegenerative disorders\, prevention strategies of PD/neurodegenerative disorders and the BC Brain Wellness Program. She will also discuss clinical/fundamental research integration. \n  \nTo join via Zoom\, please access the link here.
URL:https://scienceinvancouver.com/event/zoom-talk-movement-disorders-group-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200612T110000
DTEND;TZID=America/Vancouver:20200612T120000
DTSTAMP:20260404T184923
CREATED:20200608T171102Z
LAST-MODIFIED:20200608T171102Z
UID:32341-1591959600-1591963200@scienceinvancouver.com
SUMMARY:Zoom Talk: Movement Disorders Group
DESCRIPTION:This talk is being presented by the DMCBH movement disorders group. \nVesna Sossi will discuss new insights into Parkinson’s disease coming from novel analysis methods applied to PET and multimodality imaging such as network analysis applied to neurotransmitter PET\, outcomes from multitracer PET and brain energetics with PET/MR. \nJon Stoessl will talk about tau/progression\, segregation of function and COVID-19 as a risk factor for PD. \nMartin McKeown will cover patient video monitoring\, Deep Learning and Electrical Vestibular Stimulation\, myelin imaging in PD\, and fMRI motion correction\, data fusion\, and brainstem activation. \nSilke Cresswell will discuss the role of the microbiome in PD/neurodegenerative disorders\, prevention strategies of PD/neurodegenerative disorders and the BC Brain Wellness Program. She will also discuss clinical/fundamental research integration. \n  \nTo join via Zoom\, please access the link here.
URL:https://scienceinvancouver.com/event/zoom-talk-movement-disorders-group-5/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T090000
DTEND;TZID=America/Vancouver:20200617T100000
DTSTAMP:20260404T184923
CREATED:20200615T181646Z
LAST-MODIFIED:20200615T181646Z
UID:11713-1592384400-1592388000@scienceinvancouver.com
SUMMARY:New Horizons in Therapeutic Antibody Discovery: Challenges and Opportunities for Improvement
DESCRIPTION:Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anticancer immunotherapeutics such as checkpoint modulation\, adoptive cell therapy\, and bispecific T-cell engagers. While these approaches use different tactics to attack tumors\, they often employ monoclonal antibodies to target specific antigens. In this highly competitive field\, it is crucial to identify candidate antibodies with superior target reactivity. The first step in this process involves screening antibody libraries to identify binders. This can be achieved by using either display technologies or animal immunization. Once antibodies have been identified and slated for production\, they must be further characterized and tested for performance-related characteristics before moving into preclinical testing. \nDuring the webinar\, the speakers will: \n\nProvide an overview of the therapeutic antibody discovery landscape\nDiscuss the successes and limitations of current antibody discovery technologies\nOffer case studies of antibody screening and characterization\nAnswer viewer questions during the live broadcast.
URL:https://scienceinvancouver.com/event/new-horizons-in-therapeutic-antibody-discovery-challenges-and-opportunities-for-improvement/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T090000
DTEND;TZID=America/Vancouver:20200617T100000
DTSTAMP:20260404T184923
CREATED:20200615T181646Z
LAST-MODIFIED:20200615T181646Z
UID:26192-1592384400-1592388000@scienceinvancouver.com
SUMMARY:New Horizons in Therapeutic Antibody Discovery: Challenges and Opportunities for Improvement
DESCRIPTION:Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anticancer immunotherapeutics such as checkpoint modulation\, adoptive cell therapy\, and bispecific T-cell engagers. While these approaches use different tactics to attack tumors\, they often employ monoclonal antibodies to target specific antigens. In this highly competitive field\, it is crucial to identify candidate antibodies with superior target reactivity. The first step in this process involves screening antibody libraries to identify binders. This can be achieved by using either display technologies or animal immunization. Once antibodies have been identified and slated for production\, they must be further characterized and tested for performance-related characteristics before moving into preclinical testing. \nDuring the webinar\, the speakers will: \n\nProvide an overview of the therapeutic antibody discovery landscape\nDiscuss the successes and limitations of current antibody discovery technologies\nOffer case studies of antibody screening and characterization\nAnswer viewer questions during the live broadcast.
URL:https://scienceinvancouver.com/event/new-horizons-in-therapeutic-antibody-discovery-challenges-and-opportunities-for-improvement-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T090000
DTEND;TZID=America/Vancouver:20200617T100000
DTSTAMP:20260404T184923
CREATED:20200615T181646Z
LAST-MODIFIED:20200615T181646Z
UID:27807-1592384400-1592388000@scienceinvancouver.com
SUMMARY:New Horizons in Therapeutic Antibody Discovery: Challenges and Opportunities for Improvement
DESCRIPTION:Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anticancer immunotherapeutics such as checkpoint modulation\, adoptive cell therapy\, and bispecific T-cell engagers. While these approaches use different tactics to attack tumors\, they often employ monoclonal antibodies to target specific antigens. In this highly competitive field\, it is crucial to identify candidate antibodies with superior target reactivity. The first step in this process involves screening antibody libraries to identify binders. This can be achieved by using either display technologies or animal immunization. Once antibodies have been identified and slated for production\, they must be further characterized and tested for performance-related characteristics before moving into preclinical testing. \nDuring the webinar\, the speakers will: \n\nProvide an overview of the therapeutic antibody discovery landscape\nDiscuss the successes and limitations of current antibody discovery technologies\nOffer case studies of antibody screening and characterization\nAnswer viewer questions during the live broadcast.
URL:https://scienceinvancouver.com/event/new-horizons-in-therapeutic-antibody-discovery-challenges-and-opportunities-for-improvement-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T090000
DTEND;TZID=America/Vancouver:20200617T100000
DTSTAMP:20260404T184923
CREATED:20200615T181646Z
LAST-MODIFIED:20200615T181646Z
UID:30890-1592384400-1592388000@scienceinvancouver.com
SUMMARY:New Horizons in Therapeutic Antibody Discovery: Challenges and Opportunities for Improvement
DESCRIPTION:Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anticancer immunotherapeutics such as checkpoint modulation\, adoptive cell therapy\, and bispecific T-cell engagers. While these approaches use different tactics to attack tumors\, they often employ monoclonal antibodies to target specific antigens. In this highly competitive field\, it is crucial to identify candidate antibodies with superior target reactivity. The first step in this process involves screening antibody libraries to identify binders. This can be achieved by using either display technologies or animal immunization. Once antibodies have been identified and slated for production\, they must be further characterized and tested for performance-related characteristics before moving into preclinical testing. \nDuring the webinar\, the speakers will: \n\nProvide an overview of the therapeutic antibody discovery landscape\nDiscuss the successes and limitations of current antibody discovery technologies\nOffer case studies of antibody screening and characterization\nAnswer viewer questions during the live broadcast.
URL:https://scienceinvancouver.com/event/new-horizons-in-therapeutic-antibody-discovery-challenges-and-opportunities-for-improvement-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T090000
DTEND;TZID=America/Vancouver:20200617T100000
DTSTAMP:20260404T184923
CREATED:20200615T181646Z
LAST-MODIFIED:20200615T181646Z
UID:32350-1592384400-1592388000@scienceinvancouver.com
SUMMARY:New Horizons in Therapeutic Antibody Discovery: Challenges and Opportunities for Improvement
DESCRIPTION:Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anticancer immunotherapeutics such as checkpoint modulation\, adoptive cell therapy\, and bispecific T-cell engagers. While these approaches use different tactics to attack tumors\, they often employ monoclonal antibodies to target specific antigens. In this highly competitive field\, it is crucial to identify candidate antibodies with superior target reactivity. The first step in this process involves screening antibody libraries to identify binders. This can be achieved by using either display technologies or animal immunization. Once antibodies have been identified and slated for production\, they must be further characterized and tested for performance-related characteristics before moving into preclinical testing. \nDuring the webinar\, the speakers will: \n\nProvide an overview of the therapeutic antibody discovery landscape\nDiscuss the successes and limitations of current antibody discovery technologies\nOffer case studies of antibody screening and characterization\nAnswer viewer questions during the live broadcast.
URL:https://scienceinvancouver.com/event/new-horizons-in-therapeutic-antibody-discovery-challenges-and-opportunities-for-improvement-5/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T100000
DTEND;TZID=America/Vancouver:20200617T170000
DTSTAMP:20260404T184923
CREATED:20200608T171343Z
LAST-MODIFIED:20200608T171343Z
UID:11646-1592388000-1592413200@scienceinvancouver.com
SUMMARY:Stem Cells from the Sofa Speaker Series: Stem Cell Network's's COVID-19 Rapid Response Initiative Projects
DESCRIPTION:In this episode of Stem Cells from the Sofa\, we will hear from the lead investigators of the three projects funded through SCN’s COVID-19 Rapid Response Initiative in April. \nDr. Julien Muffat\, The Hospital for Sick Children\, Toronto: “Investigating the Impact of COVID-19 on the Brain\, Using Neuro-Immune Human Tissue Culture Models Derived from Stem Cells.”\nDr. Muffat will discuss the work his team is performing to understand which types of human brain cells can be infected by the SARS-CoV-2 virus\, how these cells respond once infected\, and which genes control brain cell infection and response. \nDr. William Stanford\, Ottawa Hospital Research Institute: “Modelling COVID-19 with human stem cell derived tissues.”\nDr. Stanford will describe his project to use human tissue models to investigate how the cells that line the lungs and airways become infected by the SARS-CoV-2 virus and how the behaviour of these cells changes once they are infected. \nDr. Duncan Stewart\, Ottawa Hospital Research Institute: “Cellular Immuno-Therapy for COVID-19 related ARDS – the CIRCA-19 Trials”\nDr. Stewart will outline the CIRCA-19 clinical trial that his team is undertaking to evaluate a cell therapy aimed at reducing the impacts of acute respiratory distress associated with severe COVID-19 symptoms.
URL:https://scienceinvancouver.com/event/stem-cells-from-the-sofa-speaker-series-stem-cell-networkss-covid-19-rapid-response-initiative-projects/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/04/Stem-Cells-from-the-Sofa.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T100000
DTEND;TZID=America/Vancouver:20200617T170000
DTSTAMP:20260404T184923
CREATED:20200608T171343Z
LAST-MODIFIED:20200608T171343Z
UID:26184-1592388000-1592413200@scienceinvancouver.com
SUMMARY:Stem Cells from the Sofa Speaker Series: Stem Cell Network's's COVID-19 Rapid Response Initiative Projects
DESCRIPTION:In this episode of Stem Cells from the Sofa\, we will hear from the lead investigators of the three projects funded through SCN’s COVID-19 Rapid Response Initiative in April. \nDr. Julien Muffat\, The Hospital for Sick Children\, Toronto: “Investigating the Impact of COVID-19 on the Brain\, Using Neuro-Immune Human Tissue Culture Models Derived from Stem Cells.”\nDr. Muffat will discuss the work his team is performing to understand which types of human brain cells can be infected by the SARS-CoV-2 virus\, how these cells respond once infected\, and which genes control brain cell infection and response. \nDr. William Stanford\, Ottawa Hospital Research Institute: “Modelling COVID-19 with human stem cell derived tissues.”\nDr. Stanford will describe his project to use human tissue models to investigate how the cells that line the lungs and airways become infected by the SARS-CoV-2 virus and how the behaviour of these cells changes once they are infected. \nDr. Duncan Stewart\, Ottawa Hospital Research Institute: “Cellular Immuno-Therapy for COVID-19 related ARDS – the CIRCA-19 Trials”\nDr. Stewart will outline the CIRCA-19 clinical trial that his team is undertaking to evaluate a cell therapy aimed at reducing the impacts of acute respiratory distress associated with severe COVID-19 symptoms.
URL:https://scienceinvancouver.com/event/stem-cells-from-the-sofa-speaker-series-stem-cell-networkss-covid-19-rapid-response-initiative-projects-2/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/04/Stem-Cells-from-the-Sofa.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T100000
DTEND;TZID=America/Vancouver:20200617T170000
DTSTAMP:20260404T184923
CREATED:20200608T171343Z
LAST-MODIFIED:20200608T171343Z
UID:27799-1592388000-1592413200@scienceinvancouver.com
SUMMARY:Stem Cells from the Sofa Speaker Series: Stem Cell Network's's COVID-19 Rapid Response Initiative Projects
DESCRIPTION:In this episode of Stem Cells from the Sofa\, we will hear from the lead investigators of the three projects funded through SCN’s COVID-19 Rapid Response Initiative in April. \nDr. Julien Muffat\, The Hospital for Sick Children\, Toronto: “Investigating the Impact of COVID-19 on the Brain\, Using Neuro-Immune Human Tissue Culture Models Derived from Stem Cells.”\nDr. Muffat will discuss the work his team is performing to understand which types of human brain cells can be infected by the SARS-CoV-2 virus\, how these cells respond once infected\, and which genes control brain cell infection and response. \nDr. William Stanford\, Ottawa Hospital Research Institute: “Modelling COVID-19 with human stem cell derived tissues.”\nDr. Stanford will describe his project to use human tissue models to investigate how the cells that line the lungs and airways become infected by the SARS-CoV-2 virus and how the behaviour of these cells changes once they are infected. \nDr. Duncan Stewart\, Ottawa Hospital Research Institute: “Cellular Immuno-Therapy for COVID-19 related ARDS – the CIRCA-19 Trials”\nDr. Stewart will outline the CIRCA-19 clinical trial that his team is undertaking to evaluate a cell therapy aimed at reducing the impacts of acute respiratory distress associated with severe COVID-19 symptoms.
URL:https://scienceinvancouver.com/event/stem-cells-from-the-sofa-speaker-series-stem-cell-networkss-covid-19-rapid-response-initiative-projects-3/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/04/Stem-Cells-from-the-Sofa.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T100000
DTEND;TZID=America/Vancouver:20200617T170000
DTSTAMP:20260404T184923
CREATED:20200608T171343Z
LAST-MODIFIED:20200608T171343Z
UID:30882-1592388000-1592413200@scienceinvancouver.com
SUMMARY:Stem Cells from the Sofa Speaker Series: Stem Cell Network's's COVID-19 Rapid Response Initiative Projects
DESCRIPTION:In this episode of Stem Cells from the Sofa\, we will hear from the lead investigators of the three projects funded through SCN’s COVID-19 Rapid Response Initiative in April. \nDr. Julien Muffat\, The Hospital for Sick Children\, Toronto: “Investigating the Impact of COVID-19 on the Brain\, Using Neuro-Immune Human Tissue Culture Models Derived from Stem Cells.”\nDr. Muffat will discuss the work his team is performing to understand which types of human brain cells can be infected by the SARS-CoV-2 virus\, how these cells respond once infected\, and which genes control brain cell infection and response. \nDr. William Stanford\, Ottawa Hospital Research Institute: “Modelling COVID-19 with human stem cell derived tissues.”\nDr. Stanford will describe his project to use human tissue models to investigate how the cells that line the lungs and airways become infected by the SARS-CoV-2 virus and how the behaviour of these cells changes once they are infected. \nDr. Duncan Stewart\, Ottawa Hospital Research Institute: “Cellular Immuno-Therapy for COVID-19 related ARDS – the CIRCA-19 Trials”\nDr. Stewart will outline the CIRCA-19 clinical trial that his team is undertaking to evaluate a cell therapy aimed at reducing the impacts of acute respiratory distress associated with severe COVID-19 symptoms.
URL:https://scienceinvancouver.com/event/stem-cells-from-the-sofa-speaker-series-stem-cell-networkss-covid-19-rapid-response-initiative-projects-4/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/04/Stem-Cells-from-the-Sofa.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T100000
DTEND;TZID=America/Vancouver:20200617T170000
DTSTAMP:20260404T184923
CREATED:20200608T171343Z
LAST-MODIFIED:20200608T171343Z
UID:32342-1592388000-1592413200@scienceinvancouver.com
SUMMARY:Stem Cells from the Sofa Speaker Series: Stem Cell Network's's COVID-19 Rapid Response Initiative Projects
DESCRIPTION:In this episode of Stem Cells from the Sofa\, we will hear from the lead investigators of the three projects funded through SCN’s COVID-19 Rapid Response Initiative in April. \nDr. Julien Muffat\, The Hospital for Sick Children\, Toronto: “Investigating the Impact of COVID-19 on the Brain\, Using Neuro-Immune Human Tissue Culture Models Derived from Stem Cells.”\nDr. Muffat will discuss the work his team is performing to understand which types of human brain cells can be infected by the SARS-CoV-2 virus\, how these cells respond once infected\, and which genes control brain cell infection and response. \nDr. William Stanford\, Ottawa Hospital Research Institute: “Modelling COVID-19 with human stem cell derived tissues.”\nDr. Stanford will describe his project to use human tissue models to investigate how the cells that line the lungs and airways become infected by the SARS-CoV-2 virus and how the behaviour of these cells changes once they are infected. \nDr. Duncan Stewart\, Ottawa Hospital Research Institute: “Cellular Immuno-Therapy for COVID-19 related ARDS – the CIRCA-19 Trials”\nDr. Stewart will outline the CIRCA-19 clinical trial that his team is undertaking to evaluate a cell therapy aimed at reducing the impacts of acute respiratory distress associated with severe COVID-19 symptoms.
URL:https://scienceinvancouver.com/event/stem-cells-from-the-sofa-speaker-series-stem-cell-networkss-covid-19-rapid-response-initiative-projects-5/
LOCATION:Online
ATTACH;FMTTYPE=image/png:https://scienceinvancouver.com/wp-content/uploads/sites/1/2020/04/Stem-Cells-from-the-Sofa.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T150000
DTEND;TZID=America/Vancouver:20200617T160000
DTSTAMP:20260404T184923
CREATED:20200609T221205Z
LAST-MODIFIED:20200609T222807Z
UID:11670-1592406000-1592409600@scienceinvancouver.com
SUMMARY:Seminar: Single-Cell RNA Sequencing with Split-Pool Barcoding from the Brain to Bacteria
DESCRIPTION:Michael Smith Laboratories presents a seminar by\n\n\n\n  \nDr. Georg Seelig\nAssociate Professor \nDepartment of Electrical Engineering and Computer Science & Engineering \nUniversity of Washington \nHosted by Thibault Mayor \n  \n  \n\n“Single-cell RNA sequencing with split-pool barcoding from the brain to bacteria”\nAbstract: \nTo facilitate scalable profiling of single cells\, we developed split-pool ligation-based transcriptome sequencing (SPLiT-seq)\, a single-cell RNA-seq (scRNA-seq) method that labels the cellular origin of RNA through combinatorial barcoding. SPLiT-seq  eliminates the need to isolate single cells\, is compatible with fixed cells or nuclei\, allows efficient sample multiplexing\, and requires no customized equipment. We initially used SPLiT-seq to analyze over 150\,000 single-nucleus transcriptomes from mouse brain and spinal cord. More than 100 cell types were identified\, with gene expression patterns corresponding to cellular function\, regional specificity\, and stage of differentiation. Pseudotime analysis revealed transcriptional programs driving four developmental lineages\, providing a snapshot of early postnatal development in the murine central nervous system. \nMore recently\, we have adapted SPLiT-seq to work with bacteria\, resulting in the first high-throughput scRNA-seq technology for microbes. We tested out method on both gram positive (B. subtilis) and gram negative (E. coli) bacteria and validate it using heat shock treatment. We then apply it to investigate the transition from exponential growth to stationary phase in B. subtilis. We not only find detailed gene expression profiles associated with known (and rare) states such as competence but also identify novel and unexpected gene expression states such as a sub-population associated with inositol metabolism that appears to be controlled through a bistable switch network. \n  \nClick here for Zoom meeting access \nMeeting ID: 944 7599 4344 Password: 559087 \n  \nDial by your location\n+1 587 328 1099 Canada\n+1 647 374 4685 Canada\n+1 647 558 0588 Canada\n+1 778 907 2071 Canada\n+1 438 809 7799 Canada\nMeeting ID: 944 7599 4344
URL:https://scienceinvancouver.com/event/msl-seminar-series-georg-seelig/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T150000
DTEND;TZID=America/Vancouver:20200617T160000
DTSTAMP:20260404T184923
CREATED:20200609T221205Z
LAST-MODIFIED:20200609T221205Z
UID:26189-1592406000-1592409600@scienceinvancouver.com
SUMMARY:Seminar: Single-Cell RNA Sequencing with Split-Pool Barcoding from the Brain to Bacteria
DESCRIPTION:Michael Smith Laboratories presents a seminar by\n\n\n\n  \nDr. Georg Seelig\nAssociate Professor \nDepartment of Electrical Engineering and Computer Science & Engineering \nUniversity of Washington \nHosted by Thibault Mayor \n  \n  \n\n“Single-cell RNA sequencing with split-pool barcoding from the brain to bacteria”\nAbstract: \nTo facilitate scalable profiling of single cells\, we developed split-pool ligation-based transcriptome sequencing (SPLiT-seq)\, a single-cell RNA-seq (scRNA-seq) method that labels the cellular origin of RNA through combinatorial barcoding. SPLiT-seq  eliminates the need to isolate single cells\, is compatible with fixed cells or nuclei\, allows efficient sample multiplexing\, and requires no customized equipment. We initially used SPLiT-seq to analyze over 150\,000 single-nucleus transcriptomes from mouse brain and spinal cord. More than 100 cell types were identified\, with gene expression patterns corresponding to cellular function\, regional specificity\, and stage of differentiation. Pseudotime analysis revealed transcriptional programs driving four developmental lineages\, providing a snapshot of early postnatal development in the murine central nervous system. \nMore recently\, we have adapted SPLiT-seq to work with bacteria\, resulting in the first high-throughput scRNA-seq technology for microbes. We tested out method on both gram positive (B. subtilis) and gram negative (E. coli) bacteria and validate it using heat shock treatment. We then apply it to investigate the transition from exponential growth to stationary phase in B. subtilis. We not only find detailed gene expression profiles associated with known (and rare) states such as competence but also identify novel and unexpected gene expression states such as a sub-population associated with inositol metabolism that appears to be controlled through a bistable switch network. \n  \nClick here for Zoom meeting access \nMeeting ID: 944 7599 4344 Password: 559087 \n  \nDial by your location\n+1 587 328 1099 Canada\n+1 647 374 4685 Canada\n+1 647 558 0588 Canada\n+1 778 907 2071 Canada\n+1 438 809 7799 Canada\nMeeting ID: 944 7599 4344
URL:https://scienceinvancouver.com/event/msl-seminar-series-georg-seelig-2/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T150000
DTEND;TZID=America/Vancouver:20200617T160000
DTSTAMP:20260404T184923
CREATED:20200609T221205Z
LAST-MODIFIED:20200609T221205Z
UID:27804-1592406000-1592409600@scienceinvancouver.com
SUMMARY:Seminar: Single-Cell RNA Sequencing with Split-Pool Barcoding from the Brain to Bacteria
DESCRIPTION:Michael Smith Laboratories presents a seminar by\n\n\n\n  \nDr. Georg Seelig\nAssociate Professor \nDepartment of Electrical Engineering and Computer Science & Engineering \nUniversity of Washington \nHosted by Thibault Mayor \n  \n  \n\n“Single-cell RNA sequencing with split-pool barcoding from the brain to bacteria”\nAbstract: \nTo facilitate scalable profiling of single cells\, we developed split-pool ligation-based transcriptome sequencing (SPLiT-seq)\, a single-cell RNA-seq (scRNA-seq) method that labels the cellular origin of RNA through combinatorial barcoding. SPLiT-seq  eliminates the need to isolate single cells\, is compatible with fixed cells or nuclei\, allows efficient sample multiplexing\, and requires no customized equipment. We initially used SPLiT-seq to analyze over 150\,000 single-nucleus transcriptomes from mouse brain and spinal cord. More than 100 cell types were identified\, with gene expression patterns corresponding to cellular function\, regional specificity\, and stage of differentiation. Pseudotime analysis revealed transcriptional programs driving four developmental lineages\, providing a snapshot of early postnatal development in the murine central nervous system. \nMore recently\, we have adapted SPLiT-seq to work with bacteria\, resulting in the first high-throughput scRNA-seq technology for microbes. We tested out method on both gram positive (B. subtilis) and gram negative (E. coli) bacteria and validate it using heat shock treatment. We then apply it to investigate the transition from exponential growth to stationary phase in B. subtilis. We not only find detailed gene expression profiles associated with known (and rare) states such as competence but also identify novel and unexpected gene expression states such as a sub-population associated with inositol metabolism that appears to be controlled through a bistable switch network. \n  \nClick here for Zoom meeting access \nMeeting ID: 944 7599 4344 Password: 559087 \n  \nDial by your location\n+1 587 328 1099 Canada\n+1 647 374 4685 Canada\n+1 647 558 0588 Canada\n+1 778 907 2071 Canada\n+1 438 809 7799 Canada\nMeeting ID: 944 7599 4344
URL:https://scienceinvancouver.com/event/msl-seminar-series-georg-seelig-3/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T150000
DTEND;TZID=America/Vancouver:20200617T160000
DTSTAMP:20260404T184923
CREATED:20200609T221205Z
LAST-MODIFIED:20200609T221205Z
UID:30887-1592406000-1592409600@scienceinvancouver.com
SUMMARY:Seminar: Single-Cell RNA Sequencing with Split-Pool Barcoding from the Brain to Bacteria
DESCRIPTION:Michael Smith Laboratories presents a seminar by\n\n\n\n  \nDr. Georg Seelig\nAssociate Professor \nDepartment of Electrical Engineering and Computer Science & Engineering \nUniversity of Washington \nHosted by Thibault Mayor \n  \n  \n\n“Single-cell RNA sequencing with split-pool barcoding from the brain to bacteria”\nAbstract: \nTo facilitate scalable profiling of single cells\, we developed split-pool ligation-based transcriptome sequencing (SPLiT-seq)\, a single-cell RNA-seq (scRNA-seq) method that labels the cellular origin of RNA through combinatorial barcoding. SPLiT-seq  eliminates the need to isolate single cells\, is compatible with fixed cells or nuclei\, allows efficient sample multiplexing\, and requires no customized equipment. We initially used SPLiT-seq to analyze over 150\,000 single-nucleus transcriptomes from mouse brain and spinal cord. More than 100 cell types were identified\, with gene expression patterns corresponding to cellular function\, regional specificity\, and stage of differentiation. Pseudotime analysis revealed transcriptional programs driving four developmental lineages\, providing a snapshot of early postnatal development in the murine central nervous system. \nMore recently\, we have adapted SPLiT-seq to work with bacteria\, resulting in the first high-throughput scRNA-seq technology for microbes. We tested out method on both gram positive (B. subtilis) and gram negative (E. coli) bacteria and validate it using heat shock treatment. We then apply it to investigate the transition from exponential growth to stationary phase in B. subtilis. We not only find detailed gene expression profiles associated with known (and rare) states such as competence but also identify novel and unexpected gene expression states such as a sub-population associated with inositol metabolism that appears to be controlled through a bistable switch network. \n  \nClick here for Zoom meeting access \nMeeting ID: 944 7599 4344 Password: 559087 \n  \nDial by your location\n+1 587 328 1099 Canada\n+1 647 374 4685 Canada\n+1 647 558 0588 Canada\n+1 778 907 2071 Canada\n+1 438 809 7799 Canada\nMeeting ID: 944 7599 4344
URL:https://scienceinvancouver.com/event/msl-seminar-series-georg-seelig-4/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Vancouver:20200617T150000
DTEND;TZID=America/Vancouver:20200617T160000
DTSTAMP:20260404T184923
CREATED:20200609T221205Z
LAST-MODIFIED:20200609T221205Z
UID:32347-1592406000-1592409600@scienceinvancouver.com
SUMMARY:Seminar: Single-Cell RNA Sequencing with Split-Pool Barcoding from the Brain to Bacteria
DESCRIPTION:Michael Smith Laboratories presents a seminar by\n\n\n\n  \nDr. Georg Seelig\nAssociate Professor \nDepartment of Electrical Engineering and Computer Science & Engineering \nUniversity of Washington \nHosted by Thibault Mayor \n  \n  \n\n“Single-cell RNA sequencing with split-pool barcoding from the brain to bacteria”\nAbstract: \nTo facilitate scalable profiling of single cells\, we developed split-pool ligation-based transcriptome sequencing (SPLiT-seq)\, a single-cell RNA-seq (scRNA-seq) method that labels the cellular origin of RNA through combinatorial barcoding. SPLiT-seq  eliminates the need to isolate single cells\, is compatible with fixed cells or nuclei\, allows efficient sample multiplexing\, and requires no customized equipment. We initially used SPLiT-seq to analyze over 150\,000 single-nucleus transcriptomes from mouse brain and spinal cord. More than 100 cell types were identified\, with gene expression patterns corresponding to cellular function\, regional specificity\, and stage of differentiation. Pseudotime analysis revealed transcriptional programs driving four developmental lineages\, providing a snapshot of early postnatal development in the murine central nervous system. \nMore recently\, we have adapted SPLiT-seq to work with bacteria\, resulting in the first high-throughput scRNA-seq technology for microbes. We tested out method on both gram positive (B. subtilis) and gram negative (E. coli) bacteria and validate it using heat shock treatment. We then apply it to investigate the transition from exponential growth to stationary phase in B. subtilis. We not only find detailed gene expression profiles associated with known (and rare) states such as competence but also identify novel and unexpected gene expression states such as a sub-population associated with inositol metabolism that appears to be controlled through a bistable switch network. \n  \nClick here for Zoom meeting access \nMeeting ID: 944 7599 4344 Password: 559087 \n  \nDial by your location\n+1 587 328 1099 Canada\n+1 647 374 4685 Canada\n+1 647 558 0588 Canada\n+1 778 907 2071 Canada\n+1 438 809 7799 Canada\nMeeting ID: 944 7599 4344
URL:https://scienceinvancouver.com/event/msl-seminar-series-georg-seelig-5/
LOCATION:Online
END:VEVENT
END:VCALENDAR