Website BC Cancer
Staff Scientist/Leader, Integrated Mouse Modelling Services (IMMS)
Terry Fox Laboratories, BC Cancer, Vancouver
Reporting to the Scientific Director, BC Cancer Animal Resource Centre, the Leader, Integrated Mouse Modelling Services (IMMS) will be responsible for the operation and expansion of a mouse genetic modelling core for BC Cancer and the University of British Columbia. The IMMS will evolve from the current Genetic Modelling Core located at BC Cancer Research Institute (BCCRI). The Leader will have oversight of all services offered by the IMMS, while also evaluating and implementing new emerging mouse genetic modification technologies to provide scientific support and services to BC Cancer, UBC and other external research teams on fee for service basis. The Leader will also be expected to develop a strategic plan for growth of the IMMS while also acting as a mentor for other IMMS research personnel. The Leader must be passionate about mouse genetics models and mouse pluripotent stem cells and their application to disease models while also having an appreciation for building collaborative relationships with diverse groups with mouse modelling needs. Furthermore, this position involves insights into scientific structures, processes of relevant research alliances, a high degree of creativity, interdisciplinary and transdisciplinary thinking.
The Leader, IMMS will provide a vision for the implementation of a successful IMMS at the BC Cancer Research Institute, responsibilities include:
Establishment and Provision of the following services based on fee for service model:
Generation of new mouse models: Assisting researchers with experimental design to determine the best approach to meet their needs. Services include embryonic stem cell modification and, zygote and embryo injections. CRISPR-Cas9 methods and standard methods are used.
Cryopreservation and Rederivation of mouse lines: Cryopreservation of mouse sperm and embryos for long term storage and, IVF and embryo transfer methods for recovery and rederivation.
Scientific Support and Collaboration:
Write letters and provide quotations as support in grant applications for researchers planning to use the core.
Fully document research work and assist researchers in the preparation of manuscripts by providing experimental details.
Collaborate with other cores at UBC to provide continuity in services for research projects.
Management and Finance:
Manage the core facility and its staff, including recruitment, retention and termination.
Present core services to potential users inside and outside UBC; establish contacts in and outside BCCRI to raise the profile of the IMMS; develop a communication (via seminars, emails and social media platform) and advertising plan for IMMS core services.
Report to the Scientific Director, Animal Resource Centre on the current use and potential needs for growth and diversification of the core.
Provide financial evaluation of new projects, technologies and operation of the core; develops funding models for sustainment
Prepare budgets and develop efficient tools for billing and accounting of fee for service model
Track deliverables for IMMS projects to ensure success of core
Collaborate with the Operations Manager, Animal Resource Centre around staffing and provision of specialized services
What you bring
PhD in Genetics, Molecular Biology or related discipline.
Seven (7) years relevant experience or equivalent combination of education and experience.
You Have
Demonstrated experience in genome engineering and mouse genetic models,
Knowledge of generating budgets and costing structures for various services offered by the core.
Established knowledge of laboratory safety plans and procedures to ensure compliance with applicable federal, provincial and local regulations.
Effective oral, written, interpersonal, analytical, organizational skills and scheduling abilities.
Demonstrated integrity, credibility, and a positive attitude.
Experience in developing and implementing standard operating procedures.
Strong English communications skills (verbal and written).
Ability to convey concepts and analysis results to non-specialists.
Self-directed, self-motivated and independent research skills.
Ability to mentor and direct junior staff and trainees.
Develop, prioritize and implement multiple time-sensitive research projects.
A strong publication record is a definite asset.
