First, we show that models of depression in mouse produce brain function changes resembling those observed in humans who are depressed. This, of course, opens up the possibility of testing questions that are prohibitive in humans. As such, we used a next generation fluorescent sensor that allowed us to look at a specific neurotransmitter system...
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On September 14, 2017, Dr. Michael Coughtrie, Professor and Dean of the Faculty of Pharmaceutical Sciences at the University of British Columbia (UBC) was named a fellow of the Canadian Academy of Health Sciences (CAHS). Dr. Coughtrie, together with UBC President and Vice-Chancellor Dr. Santa J. Ono, and Drs. Jehannine Austin and Lara Boyd from UBC Faculty of Medicine, were…
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Prime Minister Justin Trudeau has selected Ottawa heart researcher Mona Nemer to be the country’s top scientist. Nemer leaves her position as the vice-president of research at the University of Ottawa after more than a decade to take on the title of Canada’s chief science adviser. The appointment fulfils an election promise and ticks off one of Science Minister Kirsty…
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In a partnership with Dr. Sue Baldwin at the University of British Columbia, and with funding from Genome BC, Teck Resources Limited (Teck) is exploring how to optimize the use of microbes in water treatment to reduce selenium. Selenium is a naturally-occurring substance that can be released through the mining process and impact aquatic health in high quantities. The research…
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UBC Researchers Promote the Fundamental Science Review on Parliament Hill

“Based on data from a survey we produced last year, 80 per cent of Canadian Principal Investigators (PIs) have indicated plans to slow their research programs,” says Dr. Liisa Galea. “They’re worried about how they’re going to support new trainees, and funding is their primary concern.” Dr. Galea recently travelled to Ottawa in support of the Fundamental Science Review as part of a…
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Engineered T-cell receptors (TCRs) have tremendous therapeutic potential for targeted, T-cell-mediated killing of infected or malignant cells. A key hurdle in realizing this vision is understanding and manipulating the interactions of TCRs with their cognate antigens. Rules for TCR engagement have been difficult to define owing to the complexity of the system, and platforms for de novo TCR design remain aspirational. A…
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2017 Neil Mackenzie Mentorship Excellence Award

Since 2015, the Centre for Blood Research (CBR) has offered an award to honour the memory of Neil Mackenzie and to recognize the mentorship excellence he provided within the CBR community. Nominations for this award are open to any member of the CBR (with the exception of PIs). CBR members nominate their colleagues and lab mates who exhibit excellence in mentorship, enthusiasm,…
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Cancers, including Hodgkin lymphoma can change their face over time. Specifically in Hodgkin lymphoma, we have shown that the so called tumor microenvironment changes form initial diagnosis to relapse. This has implications for prognostication, treatment resistance and the rational choice of therapies in the era of personalized medicine. In the Journal of Clinical Oncology publication, we have developed  an assay, called RHL30, at the time point of disease relapse when testing is most needed for physicians...
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Almost half of Canadians – 43 per cent –  believe scientific findings are ‘a matter of opinion,’ a poll released Monday shows. At the same time, 81 per cent said that scientific findings were ‘objective facts,’ which means that over a third of the poll’s respondents, 38 per cent, believe both. Those who described themselves as ‘intuitive/gut feel decision-makers’ were more…
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STEMCELL Technologies has signed an exclusive license with Propagenixof Rockville, MD to commercialize its patented EpiX™ technology, a novel and revolutionary cell culture medium that enables unprecedented expansion of tissue-resident epithelial stem cells without any genetic manipulation. EpiX™ outperforms current state-of-the-art cell culture systems, which typically yield fewer than 20 population doublings before the cells senesce. Epithelial stem cells derived from many…
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