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Emulating Target Trials to Strengthen the Evidence Base for the Clinical Management of Opioid Use Disorder
September 23, 2021 - 12:00 pm - 1:15 pm
Abstract
In 2016, following a dramatic increase in opioid-related overdose deaths, the province of British Columbia (BC), Canada declared a public health emergency. Opioid agonist treatment (OAT) is among the most effective tools available to combat the epidemic. However, OAT uptake and retention is sub-optimal in BC and internationally, compromised largely by social and structural factors but also deviations from evidence-based standards of care and fragmented care, particularly for those with concurrent disorders. Furthermore, a number of aspects of Canadian and US clinical guidelines for the management of opioid use disorder are based on limited and low-quality evidence. This proposal aims to apply cutting-edge methods for causal inference in emulating a series of ‘target trials’ using BC’s extensive population-based linked administrative databases. The target trial framework channels counterfactual theory in providing a flexible basis for comparing the effects of treatment and clinical management strategies on either an intent-to-treat or per-protocol basis.
Bio
Bohdan Nosyk is an Associate Professor and St. Paul’s Hospital CANFAR Chair in HIV/AIDS Research at the Faculty of Health Sciences, and leads the Health Economic Research Unit at the BC Centre for Excellence in HIV/AIDS. Dr. Nosyk’s research seeks to inform complex policy decisions surrounding the prevention and management of HIV/AIDS and substance use disorders. He has led population-level evaluations in these disease areas in China, in the state of California and across urban centers in the US, and locally in British Columbia. He combines simulation modeling methods and cost-effectiveness analyses with econometric and biostatistical analyses of health administrative data to address these issues.
- This seminar will be held virtually over Zoom and recorded: https://sfu.zoom.us/j/69219598229?pwd=ZnZCVnR4NmNBbnpyc1FQbDVQWFFVUT09
Meeting ID: 692 1959 8229 Password: 314185 - Please visit the FHS Seminar Series webpage for further details: http://www.sfu.ca/fhs/news-events/events/seminar-series.html
- The SFU FHS Research Seminar Series is open to the SFU and the broader research community.
- The SFU FHS Research Seminar Series is an Accredited Small Group Learning by the Royal College of Physicians and Surgeons.
