A Marker for High Risk Aneurysms

The aorta is the largest artery in the body and connects the heart to the vital organs.  In 1 in 100 people, the closest part of the aorta to the heart widens, becoming an aneurysm. In the majority of cases, an aneurysm of the aorta forms when it is weak.  People with an aneurysm of the aorta are at risk…
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Study Looks at Airway Aging in People Living with HIV and COPD

Collaborating with colleagues from UBC and UCLA, BC-CfE researchers, in a novel study, looked at whether people living with HIV (PLWH) and (COPD) experience an acceleration of aging in their airways, independent of their smoking history. The study, titled “Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease” was recently published in the American Journal of Respiratory and Critical…
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Global life sciences leader Cytiva opened a new 126 200 ft2 (11 724 m2) site in the greater Vancouver area to expand manufacturing capacity of aseptic filling machines by over 200%. The machines, known as workcells, provide gloveless, robotic aseptic filling capability for final drug product into vials, syringes, and cartridges. The site will serve as a Center of Excellence…
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Meet the Winners of NMIN’s 2022 Graduate Awards

The NanoMedicines Innovation Network (NMIN) is pleased to announce the 15 recipients of the its 2022 Masters- and Doctoral-level Graduate Awards. Recipients hail from seven universities in five provinces. The goal of NMIN Graduate Awards is to enable exceptional students to pursue nanomedicine academic research training with Canadian experts. Doctoral awards provide a stipend of $30,000 a year for up to two…
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A new grant from the Weston Family Foundation through the Weston Brain Institute will support the research and development of a vaccine against neurodegenerative diseases caused by the misfolded protein alpha-synuclein (A-syn). This project features a collaborative team of neuroscientists from across Canada, led by Dr. Neil Cashman, a researcher at UBC’s Djavad Mowafaghian Centre for Brain Health and Chief Scientific Officer at ProMIS…
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Epstein-Barr virus (EBV) has been identified as a putative trigger of multiple sclerosis (MS). Previously, we reported that mice latently infected with murine gammaherpesvirus 68 (γHV-68), the murine homolog to EBV, and induced for experimental autoimmune encephalomyelitis (EAE), developed an enhanced disease more reminiscent of MS. These prior results showed that expression of CD40 on CD11b+CD11c+ cells in latently infected…
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The Wyatt laboratory studies the genomics of lethal prostate and bladder cancer. Their overall objective is to use their experience in genitourinary cancer genomics and bioinformatics to enable real-time precision oncology in the clinic. To achieve this, they perform a variety of innovative next-generation sequencing techniques on clinical specimens including tissue and liquid biopsies from individuals with metastatic castration-resistant prostate cancer and metastatic bladder cancer.
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Imprinting is a critical part of normal embryonic development in mammals, controlled by defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting control regions. Direct nanopore sequencing of DNA provides a means to detect allelic methylation and to overcome the drawbacks of methylation array and short-read technologies. Here, we used publicly available nanopore sequencing data for 12 standard B-lymphocyte…
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