Publications of the Week Apolipoprotein E Dysfunction in Alzheimer’s Disease: A Study on miRNA Regulation, Glial Markers, and Amyloid Pathology | February 11, 2025Introduction: Apolipoprotein E (ApoE) plays a crucial role in lipid homeostasis, predominantly expressed in astrocytes…karnottFebruary 11, 2025 Read More
Publications of the Week Identification of an Early Subset of Cerebellar Nuclei Neurons in MiceRahimi-Balaei, M., et al. | February 7, 2025Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from…karnottFebruary 7, 2025 Read More
Publications of the Week Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Brain AxisSullivan, O., et al. | February 6, 2025Despite recent advances in understanding the connection between the gut microbiota and the adult brain,…karnottFebruary 6, 2025 Read More
Publications of the Week Genetic Engineering of Megakaryocytes from Blood Progenitor Cells Using Messenger RNA Lipid NanoparticlesLeung, J., et al. | January 30, 2025Platelets are an essential component of hemorrhage control and management, and engineering platelets to express…karnottJanuary 30, 2025 Read More
Publications of the Week Stereotactic Ablative Radiation for Oligoprogressive Cancers: Results of the Randomized Phase 2 STOP TrialSchellenberg, D., et al. | January 24, 2025We enrolled patients with 1 to 5 metastases progressing on systemic therapy, and after stratifying…karnottJanuary 24, 2025 Read More
Publications of the Week Biochemical and Structural Characterization of Rab3GAP Reveals Insights into Rab18 Nucleotide Exchange ActivityFairlie, G., et al. | January 13, 2025The heterodimeric Rab3GAP complex is a guanine nucleotide exchange factor (GEF) for the Rab18 GTPase…karnottJanuary 13, 2025 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined NichesStankiewicz, L., et al. | January 10, 2025Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions…karnottJanuary 10, 2025 Read More
Publications of the Week SARS-CoV-2 3CLpro (Main Protease) Regulates Caspase Activation of Gasdermin-D/E Pores Leading to Secretion and Extracellular Activity of 3CLproGrin, P., et al. | January 6, 2025SARS-CoV-2 3C-like protease (3CLpro or Mpro) cleaves the SARS-CoV-2 polyprotein and >300 intracellular host proteins to…karnottJanuary 6, 2025 Read More
Publications of the Week Tracking the Gene Expression Programs and Clonal Relationships That Underlie Mast, Myeloid, and T Lineage Specification from Stem CellsMichaels, Y., et al. | December 17, 2024T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer.…karnottDecember 17, 2024 Read More
Publications of the Week Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles Is Compatible with Blood Banking PracticesStrong, C., et al. | December 10, 2024Platelets contribute to a variety of physiological processes, including inflammation, sepsis, and cancer. However, because…karnottDecember 10, 2024 Read More