Publications of the Week TMPRSS2 Inhibitors With Broad-Spectrum Efficacy Against SARS-CoV-2 (JN.1) and Influenza A (H1N1) Viruses Protect Mice From Influenza A InfectionPresley, L., et al. | May 13, 2026Human TMPRSS2 is a type II transmembrane serine protease and an essential host factor for…karnottMay 13, 2026 Read More
Publications of the Week IL1RAP Antibody-Drug Conjugates Potently Target Primary and Metastatic Disease in Multiple Oncofusion-Driven CancersZhang, H., et al. | May 4, 2026Gene fusions generated by chromosomal rearrangements function as oncogenic drivers in human cancers. We previously…karnottMay 4, 2026 Read More
Publications of the Week Drugging the Intrinsically Disordered Transactivation Domain of Androgen ReceptorObst, J., et al. | April 30, 2026Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded…karnottApril 30, 2026 Read More
Publications of the Week Single-Cell Spatial Atlas of the Aging Human BreastGupta, P., et al. | April 27, 2026Breast cancer can develop over a wide age range and tumors in younger women differ…karnottApril 27, 2026 Read More
Publications of the Week Noncanonical Functions of UGT2B17 Promote Castration-Resistant Prostate Cancer ProgressionFeng, T., et al. | April 20, 2026Androgen deprivation therapy is the primary treatment for advanced prostate tumors. While initially effective, tumor…karnottApril 20, 2026 Read More
Publications of the Week CSF1R+ Macrophage and Osteoclast Depletion Impairs Neural Crest Proliferation and Craniofacial MorphogenesisMa, F., et al. | April 16, 2026Despite a wealth of knowledge on the mechanisms underlying craniofacial morphogenesis during gestation, the roles…karnottApril 16, 2026 Read More
Publications of the Week Neonatal Lipopolysaccharide Has Long-Term Effects on Steroids and Gene Expression in the Adult Mouse BrainBajaj, H., et al. | April 7, 2026Early-life infections can exert profound and lasting effects on brain development and function, potentially through…karnottApril 7, 2026 Read More
Publications of the Week Chemogenetic Inhibition of Developmentally-Born Hippocampal Neurons But Not Loss of Adult Neurogenesis Impairs Spatial Working Memory in the RatWard, M., et al. | April 3, 2026The dentate gyrus (DG) of the hippocampus contains a heterogeneous population of granule cells, being…karnottApril 3, 2026 Read More
Publications of the Week Prospective Multicenter Study of ctDNA Versus Tumor Tissue Guiding FGFR-Targeted Therapy in Metastatic Urothelial CancerMüller, D., et al. | March 25, 2026Fibroblast growth factor receptor (FGFR) alterations are targetable in metastatic urothelial carcinoma (mUC). Identifying FGFR…karnottMarch 25, 2026 Read More
Publications of the Week A Long Noncoding RNA–Based Classifier for Identifying More Aggressive Low-Grade Ta Bladder Cancer with Elevated FGFR3 ActivityPhung, T., et al. | March 20, 2026Low-grade, stage Ta (TaLG) non–muscle-invasive bladder cancer (NMIBC) is generally nonaggressive; yet, some patients experience…karnottMarch 20, 2026 Read More