Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined NichesStankiewicz, L., et al. | October 14, 2024Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions…karnottOctober 14, 2024 Read More
Publications of the Week Discovery of Benzo[c]phenanthridine Derivatives with Potent Activity Against Multidrug-Resistant Mycobacterium tuberculosisLiang, Y., et al. | October 11, 2024Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis (TB), is the leading cause of bacterial disease-related…karnottOctober 11, 2024 Read More
Publications of the Week Genetic Engineering of Megakaryocytes from Blood Progenitor Cells Using mRNA Lipid NanoparticlesLeung, J., et al. | October 4, 2024Platelets are an essential component of hemorrhage control and management, and engineering platelets to express…karnottOctober 4, 2024 Read More
Publications of the Week Immune Regulatory and Anti-Resorptive Activities of Tanshinone IIA Sulfonate Attenuates Rheumatoid Arthritis in MicePanwar, P., et al. | September 27, 2024Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and painful joint destruction.…karnottSeptember 27, 2024 Read More
Publications of the Week Protein Is Expressed in All Major Organs After Intravenous Infusion of mRNA-Lipid Nanoparticles in SwineFerraresso, F., et al. | September 19, 2024In vivo delivery of mRNA is promising for the study of gene expression and the treatment…karnottSeptember 19, 2024 Read More
Publications of the Week Single Cell Glucose-Stimulated Insulin Secretion Assay Using Nanowell-in-Microwell PlatesJang, D., et al. | September 13, 2024Pancreatic β cells secrete insulin in response to elevated levels of glucose. Stem cell derived…karnottSeptember 13, 2024 Read More
Publications of the Week Gelsolin Regulates Receptor-Mediated and Fluid-Phase Endocytosis in PlateletsPaul, M., et al. | September 5, 2024Endocytosis is the process by which platelets incorporate extracellular molecules into their secretory granules. Endocytosis…karnottSeptember 5, 2024 Read More
Publications of the Week Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking PracticesStrong, C., et al. | September 2, 2024Platelets contribute to a variety of physiological processes including inflammation, sepsis and cancer. However, due…karnottSeptember 2, 2024 Read More
Publications of the Week A Synthetic Cytotoxic T Cell Platform for Rapidly Prototyping TCR FunctionSharma, G., et al. | August 26, 2024Current tools for functionally profiling T cell receptors with respect to cytotoxic potency and cross-reactivity…karnottAugust 26, 2024 Read More
Publications of the Week Factor V Haemostatic Diathesis Impairing Thrombin Activation, Membrane Binding and Circulating Antigen Level Due to a Novel Compound Heterozygous Mutation, Leu1821Ser and Gly2192CysTalbot, K., et al. | August 22, 2024Congenital factor V (FV) deficiency is a rare clotting disorder affecting ∼1 in 1,000,000, with…karnottAugust 22, 2024 Read More