Publications of the Week Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis NephritisBarbour, S., et al. | January 25, 2024Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy.…karnottJanuary 25, 2024 Read More
Publications of the Week Development of an Immunosuppressed Orthotopic Hepatocellular Carcinoma Rat Model for the Evaluation of Chemo- and Radioembolization TherapiesCharles, L., et al. | January 24, 2024Hepatocellular carcinoma (HCC) is widely known to be chemo-resistant and presents with significant liver disease…karnottJanuary 24, 2024 Read More
Publications of the Week DPYSL5 Is Highly Expressed in Treatment-Induced Neuroendocrine Prostate Cancer and Promotes Lineage Plasticity via EZH2/PRC2Kaarijärvi, R., et al. | January 19, 2024Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to…karnottJanuary 19, 2024 Read More
Publications of the Week Characterizing the Secretome of EGFR Mutant Lung AdenocarcinomaLuu, J., et al. | January 15, 2024Lung cancer is the leading cause of cancer related death worldwide, mainly due to the…karnottJanuary 15, 2024 Read More
Publications of the Week Multiregion Sampling of De Novo Metastatic Prostate Cancer Reveals Complex Polyclonality and Augments Clinical GenotypingWarner, E., et al. | January 12, 2024De novo metastatic prostate cancer is highly aggressive, but the paucity of routinely collected tissue…karnottJanuary 12, 2024 Read More
Publications of the Week CD248 Promotes Insulin Resistance by Binding to the Insulin Receptor and Dampening Its Insulin-Induced AutophosphorylationBenedet, P., et al. | January 12, 2024This week we profile a recent publication in EBioMedicine from the laboratory of Dr. Edward…karnottJanuary 12, 2024 Read More
Publications of the Week Investigating the Anti-cancer Potential of Pyrimethamine Analogues Through a Modern Chemical Biology LensBrown, J., et al. | January 5, 2024Pharmacological inhibition of dihydrofolate reductase (DHFR) is an established approach for treating a variety of…karnottJanuary 5, 2024 Read More
Publications of the Week RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic PotentialEspen, B., et al. | January 3, 2024RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER-associated degradation. Prostate tumor patient…karnottJanuary 3, 2024 Read More
Publications of the Week Membrane Contact Site Detection (MCS-DETECT) Reveals Dual Control of Rough Mitochondria–ER ContactsCardoen, B., et al. | December 12, 2023Identification and morphological analysis of mitochondria–ER contacts (MERCs) by fluorescent microscopy is limited by subpixel…karnottDecember 12, 2023 Read More
Publications of the Week Surface Photosterilization of Implantable Silicone Biomaterials: Structural and Functional CharacterizationGhaffari, S., et al. | December 11, 2023Hospital-acquired infections (HAIs) remain one of the major challenges faced by the global healthcare system.…karnottDecember 11, 2023 Read More