Publications of the Week Single-Cell Spatial Atlas of the Aging Human BreastGupta, P., et al. | April 27, 2026Breast cancer can develop over a wide age range and tumors in younger women differ…karnottApril 27, 2026 Read More
Publications of the Week Noncanonical Functions of UGT2B17 Promote Castration-Resistant Prostate Cancer ProgressionFeng, T., et al. | April 20, 2026Androgen deprivation therapy is the primary treatment for advanced prostate tumors. While initially effective, tumor…karnottApril 20, 2026 Read More
Publications of the Week CSF1R+ Macrophage and Osteoclast Depletion Impairs Neural Crest Proliferation and Craniofacial MorphogenesisMa, F., et al. | April 16, 2026Despite a wealth of knowledge on the mechanisms underlying craniofacial morphogenesis during gestation, the roles…karnottApril 16, 2026 Read More
Publications of the Week Neonatal Lipopolysaccharide Has Long-Term Effects on Steroids and Gene Expression in the Adult Mouse BrainBajaj, H., et al. | April 7, 2026Early-life infections can exert profound and lasting effects on brain development and function, potentially through…karnottApril 7, 2026 Read More
Publications of the Week Chemogenetic Inhibition of Developmentally-Born Hippocampal Neurons But Not Loss of Adult Neurogenesis Impairs Spatial Working Memory in the RatWard, M., et al. | April 3, 2026The dentate gyrus (DG) of the hippocampus contains a heterogeneous population of granule cells, being…karnottApril 3, 2026 Read More
Publications of the Week Prospective Multicenter Study of ctDNA Versus Tumor Tissue Guiding FGFR-Targeted Therapy in Metastatic Urothelial CancerMüller, D., et al. | March 25, 2026Fibroblast growth factor receptor (FGFR) alterations are targetable in metastatic urothelial carcinoma (mUC). Identifying FGFR…karnottMarch 25, 2026 Read More
Publications of the Week A Long Noncoding RNA–Based Classifier for Identifying More Aggressive Low-Grade Ta Bladder Cancer with Elevated FGFR3 ActivityPhung, T., et al. | March 20, 2026Low-grade, stage Ta (TaLG) non–muscle-invasive bladder cancer (NMIBC) is generally nonaggressive; yet, some patients experience…karnottMarch 20, 2026 Read More
Publications of the Week Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody ResponsesDespins, C., et al. | March 12, 2026Background: mRNA LNP technology is now being widely applied as a highly effective vaccine platform.…karnottMarch 12, 2026 Read More
Publications of the Week Formulation and Administration Timing of Lipid Derivatized JAK-Inhibitor and Corticosteroid Modulate saRNA-LNP Inflammation and ExpressionBathula, N., et al. | March 6, 2026Self-amplifying RNA (saRNA)-lipid nanoparticle (LNP) therapeutics represent a transformative advance in nucleic acid medicine, enabling…karnottMarch 6, 2026 Read More
Publications of the Week Silencing of Human HTT by Targeted CRISPR/dCas9-Mediated Epigenetic EditingTay, Y., et al. | February 23, 2026Gene silencing is widely recognized as a promising therapeutic approach for dominant monogenic disorders. Current…karnottFebruary 23, 2026 Read More