Publications of the Week A Binary Self-Amplifying Expression Platform Enabling Lipid Nanoparticle-Free Vaccines and NanomedicinesJefferies, W., et al. | January 22, 2026Conventional mRNA vaccines played a crucial role in mitigating the COVID-19 pandemic but remain hampered…karnottJanuary 22, 2026 Read More
Publications of the Week In Mouse and In Vitro Models, Bowel Preparation Promotes Pathogen Colonization, Translocation, and Exacerbation of InflammationClayton, C., et al. | January 15, 2026In the United States, an estimated 14 million colonoscopies are performed yearly, each requiring patients…karnottJanuary 15, 2026 Read More
Publications of the Week Tunable Differentiation of Human CD4+ and CD8+ T Cells From Pluripotent Stem CellsJones, R., et al. | January 13, 2026Allogeneic T cell therapies are a highly desirable option to circumvent the cost and complexity…karnottJanuary 13, 2026 Read More
Publications of the Week A Direct Role for a Mitochondrial Targeting Sequence in Signalling StressYuan, Z., et al. | January 5, 2026Mitochondrial protein import is required for maintaining organellar function1. Perturbations in this process are associated…karnottJanuary 5, 2026 Read More
Publications of the Week The Fibroblast Epigenome Underlies SS18::SSX-Mediated Transformation in Synovial SarcomaHill, L., et al. | December 16, 2025Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2)…karnottDecember 16, 2025 Read More
Publications of the Week Cryo-Electron Microscopy Reveals Sequential Binding and Activation of Ryanodine Receptors by Statin TripletsMolinarolo, S., et al. | December 8, 2025Statins are the most prescribed class of drugs and inhibit a key enzyme in the…karnottDecember 8, 2025 Read More
Publications of the Week Molecular and Imaging Biomarker Responses to Brain Mutant HTT Lowering in a Mouse Model of Huntington DiseaseCaron, N., et al. | December 1, 2025Therapies targeting mutant huntingtin (mHTT) reduction in the brain hold promise as disease-modifying treatments for…karnottDecember 1, 2025 Read More
Publications of the Week High-Throughput Bioprinting to Produce Micropatterned Neuroepithelial Tissues and Model TSC2-Deficient Brain MalformationsFarahani, N., et al. | November 28, 2025Micropatterning technology to spatially guide the self-assembly of human pluripotent stem cells (hPSCs) into neural…karnottNovember 28, 2025 Read More
Publications of the Week Decoding Amyloid Beta Clearance Systems at Inner Blood–Retina Barrier Using Three-Dimensional Ex Vivo Retinal Imaging in Alzheimer’s DiseaseWijesinghe, P., et al. | November 17, 2025Impaired amyloid beta (Aβ) clearance contributes to sporadic Alzheimer's disease (AD). This study investigated retinal…karnottNovember 17, 2025 Read More
Publications of the Week Cataloging the Potential Functional Diversity of Cacna1e Splice Variants Using Long-Read SequencingBhuiyan, S., et al. | November 13, 2025The degree to which alternative RNA splicing influences the function and structure of voltage gated…karnottNovember 13, 2025 Read More