Publications of the Week Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody ResponsesDespins, C., et al. | March 12, 2026Background: mRNA LNP technology is now being widely applied as a highly effective vaccine platform.…karnottMarch 12, 2026 Read More
Publications of the Week Formulation and Administration Timing of Lipid Derivatized JAK-Inhibitor and Corticosteroid Modulate saRNA-LNP Inflammation and ExpressionBathula, N., et al. | March 6, 2026Self-amplifying RNA (saRNA)-lipid nanoparticle (LNP) therapeutics represent a transformative advance in nucleic acid medicine, enabling…karnottMarch 6, 2026 Read More
Publications of the Week Silencing of Human HTT by Targeted CRISPR/dCas9-Mediated Epigenetic EditingTay, Y., et al. | February 23, 2026Gene silencing is widely recognized as a promising therapeutic approach for dominant monogenic disorders. Current…karnottFebruary 23, 2026 Read More
Publications of the Week Clonal Hematopoiesis After 177Lu-PSMA-617 Radioligand Therapy in Prostate CancerMunzur, A., et al. | February 20, 2026Background: Clonal hematopoiesis (CH) is a precursor state linked to risk of hematological neoplasms, and…karnottFebruary 20, 2026 Read More
Publications of the Week Direct Measurement of Free Glucocorticoids in Small Volumes of Mouse and Rat Serum Using Ultrafiltration and Liquid Chromatography-Tandem Mass SpectrometryMazurenko, A., et al. | February 17, 2026Glucocorticoids are critical steroid hormones secreted from the adrenal glands. In mice and rats, over…karnottFebruary 17, 2026 Read More
Publications of the Week Multidimensional Characterization of Tumour–Immune Architecture Reveals Clinically Relevant Classic Hodgkin Lymphoma SubtypesAoki, T., et al. | February 12, 2026The tissue architecture of classic Hodgkin Lymphoma (CHL) is unique among cancers and characterized by…karnottFebruary 12, 2026 Read More
Publications of the Week GluN2B-Specific NMDAR Positive Allosteric Modulation Reverses Cognitive and Behavioral Abnormalities in Mecp2 and Disc1 Transgenic MiceGe., Y., et al. | February 10, 2026The GluN2B subunit of N-methyl-d-aspartate receptors (NMDARs) plays a central role in synaptic development and…karnottFebruary 10, 2026 Read More
Publications of the Week A Bacteroides Synthetic Biology Toolkit To Build an in Vivo Malabsorption BiosensorMcCallum, G., et al. | February 5, 2026The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence…karnottFebruary 5, 2026 Read More
Publications of the Week Lipid Nanoparticle-Based Non-Viral in Situ Gene Editing of Congenital Ichthyosis-Causing Mutations in Human Skin ModelsApaydin, D., et al. | February 3, 2026Autosomal recessive congenital ichthyosis (ARCI) refers to a group of rare, highly debilitating skin disorders…karnottFebruary 3, 2026 Read More
Publications of the Week Noncanonical Functions of UGT2B17 Promote Castration-Resistant Prostate Cancer ProgressionFeng, T., et al. | January 29, 2026Androgen deprivation therapy is the primary treatment for advanced prostate tumors. While initially effective, tumor…karnottJanuary 29, 2026 Read More