Publications of the Week GluN2B-Specific NMDAR Positive Allosteric Modulation Reverses Cognitive and Behavioral Abnormalities in Mecp2 and Disc1 Transgenic MiceGe., Y., et al. | February 10, 2026The GluN2B subunit of N-methyl-d-aspartate receptors (NMDARs) plays a central role in synaptic development and…karnottFebruary 10, 2026 Read More
Publications of the Week A Bacteroides Synthetic Biology Toolkit To Build an in Vivo Malabsorption BiosensorMcCallum, G., et al. | February 5, 2026The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence…karnottFebruary 5, 2026 Read More
Publications of the Week Lipid Nanoparticle-Based Non-Viral in Situ Gene Editing of Congenital Ichthyosis-Causing Mutations in Human Skin ModelsApaydin, D., et al. | February 3, 2026Autosomal recessive congenital ichthyosis (ARCI) refers to a group of rare, highly debilitating skin disorders…karnottFebruary 3, 2026 Read More
Publications of the Week Noncanonical Functions of UGT2B17 Promote Castration-Resistant Prostate Cancer ProgressionFeng, T., et al. | January 29, 2026Androgen deprivation therapy is the primary treatment for advanced prostate tumors. While initially effective, tumor…karnottJanuary 29, 2026 Read More
Publications of the Week Distinct Biological Subtypes of Chronic GVHD After Pediatric Hematopoietic Cell TransplantationNg, B., et al. | January 27, 2026Chronic graft-versus-host-disease (cGVHD) is the primary nonrelapse limitation to a successful hematopoietic cell transplantation and…karnottJanuary 27, 2026 Read More
Publications of the Week A Binary Self-Amplifying Expression Platform Enabling Lipid Nanoparticle-Free Vaccines and NanomedicinesJefferies, W., et al. | January 22, 2026Conventional mRNA vaccines played a crucial role in mitigating the COVID-19 pandemic but remain hampered…karnottJanuary 22, 2026 Read More
Publications of the Week In Mouse and In Vitro Models, Bowel Preparation Promotes Pathogen Colonization, Translocation, and Exacerbation of InflammationClayton, C., et al. | January 15, 2026In the United States, an estimated 14 million colonoscopies are performed yearly, each requiring patients…karnottJanuary 15, 2026 Read More
Publications of the Week Tunable Differentiation of Human CD4+ and CD8+ T Cells From Pluripotent Stem CellsJones, R., et al. | January 13, 2026Allogeneic T cell therapies are a highly desirable option to circumvent the cost and complexity…karnottJanuary 13, 2026 Read More
Publications of the Week A Direct Role for a Mitochondrial Targeting Sequence in Signalling StressYuan, Z., et al. | January 5, 2026Mitochondrial protein import is required for maintaining organellar function1. Perturbations in this process are associated…karnottJanuary 5, 2026 Read More
Publications of the Week The Fibroblast Epigenome Underlies SS18::SSX-Mediated Transformation in Synovial SarcomaHill, L., et al. | December 16, 2025Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2)…karnottDecember 16, 2025 Read More