Publications of the Week Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human SkinBolsoni, J., et al. | December 5, 2023Read the Publication This week, Science in Vancouver profiles Dr. Sarah Hedtrich. Dr. Hedtrich is…pthomsonDecember 5, 2023 Read More
Publications of the Week Corticosteroid-Binding Globulin (SERPINA6) Consolidates Sexual Dimorphism of Adult Rat LiverToews, J.N.C., et al. | December 5, 2023Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids.…sciencecityDecember 5, 2023 Read More
Publications of the Week Nanojunctions: Specificity of Ca2+ Signaling Requires Nano-Scale Architecture of Intracellular Membrane Contact SitesFameli, N., et al. | November 28, 2023Spatio-temporal definition of Ca2+ signals involves the assembly of signaling complexes within the nano-architecture of contact…sciencecityNovember 28, 2023 Read More
Publications of the Week Targetable Lesions and Proteomes Predict Therapy Sensitivity Through Disease Evolution in Pediatric Acute Lymphoblastic LeukemiaLorentzian, A., et al. | November 23, 2023Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However,…karnottNovember 23, 2023 Read More
Publications of the Week Multiple Micronutrient Deficiencies in Early Life Cause Multi-Kingdom Alterations in the Gut Microbiome and Intrinsic Antibiotic Resistance Genes in MiceLittlejohn, P., et al. | November 22, 2023Globally, ~340 million children suffer from multiple micronutrient deficiencies, accompanied by high pathogenic burden and…karnottNovember 22, 2023 Read More
Publications of the Week Identification of Multivariable microRNA and Clinical Biomarker Panels to Predict Imatinib Response in Chronic Myeloid Leukemia at DiagnosisWu, A., et al. | November 17, 2023Imatinib Mesylate (imatinib) was once hailed as the magic bullet for chronic myeloid leukemia (CML)…sciencecityNovember 17, 2023 Read More
Publications of the Week Development of a Novel Human Triculture Model of Non-alcoholic Fatty Liver Disease and Identification of Berberine As Ameliorating Steatosis, Oxidative Stress and FibrosisRafiei, H., et al. | November 16, 2023Non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) and hepatocarcinoma is…sciencecityNovember 16, 2023 Read More
Publications of the Week Ki67 Assessment Protocol as an Integral Biomarker for Avoiding Radiotherapy in the LUMINA Breast Cancer TrialNielsen, T., et al. | November 13, 2023The LUMINA trial demonstrated a very low local recurrence rate in women ≥55 years with…sciencecityNovember 13, 2023 Read More
Publications of the Week Semaphorin 3C Promotes De Novo Steroidogenesis in Prostate Cancer CellsYenki, P., et al. | November 10, 2023Intratumoral androgen biosynthesis contributes to castration-resistant prostate cancer progression in patients treated with androgen deprivation…sciencecityNovember 10, 2023 Read More
Publications of the Week Subclonal p53 Immunostaining in the Diagnosis of Endometrial Carcinoma Molecular SubtypeHuvila, J., et al. | November 8, 2023The significance of subclonal expression of p53 (abrupt transition from wild-type to mutant-pattern staining) is…sciencecityNovember 8, 2023 Read More