Publications of the Week Cryo-Electron Microscopy Reveals Sequential Binding and Activation of Ryanodine Receptors by Statin TripletsMolinarolo, S., et al. | December 8, 2025Statins are the most prescribed class of drugs and inhibit a key enzyme in the…karnottDecember 8, 2025 Read More
Publications of the Week Molecular and Imaging Biomarker Responses to Brain Mutant HTT Lowering in a Mouse Model of Huntington DiseaseCaron, N., et al. | December 1, 2025Therapies targeting mutant huntingtin (mHTT) reduction in the brain hold promise as disease-modifying treatments for…karnottDecember 1, 2025 Read More
Publications of the Week High-Throughput Bioprinting to Produce Micropatterned Neuroepithelial Tissues and Model TSC2-Deficient Brain MalformationsFarahani, N., et al. | November 28, 2025Micropatterning technology to spatially guide the self-assembly of human pluripotent stem cells (hPSCs) into neural…karnottNovember 28, 2025 Read More
Publications of the Week Decoding Amyloid Beta Clearance Systems at Inner Blood–Retina Barrier Using Three-Dimensional Ex Vivo Retinal Imaging in Alzheimer’s DiseaseWijesinghe, P., et al. | November 17, 2025Impaired amyloid beta (Aβ) clearance contributes to sporadic Alzheimer's disease (AD). This study investigated retinal…karnottNovember 17, 2025 Read More
Publications of the Week Cataloging the Potential Functional Diversity of Cacna1e Splice Variants Using Long-Read SequencingBhuiyan, S., et al. | November 13, 2025The degree to which alternative RNA splicing influences the function and structure of voltage gated…karnottNovember 13, 2025 Read More
Publications of the Week Activity-Targeted Metaproteomics Uncovers Rare Syntrophic Bacteria Central To Anaerobic Community MetabolismFriedline, S., et al. | November 7, 2025Syntrophic microbial consortia can contribute substantially to the activity of anoxic ecosystems but are often…karnottNovember 7, 2025 Read More
Publications of the Week Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic ShockTakahashi, N., et al. | October 27, 2025To determine whether low-density lipoprotein cholesterol (LDL-C) levels, set by the balance of clearance and…karnottOctober 27, 2025 Read More
Publications of the Week Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles Across mRNA ModalitiesCasmil, I., et al. | October 23, 2025This week, we profile a recent publication in Advanced Science by Dr. Anna Blakney’s lab…karnottOctober 23, 2025 Read More
Publications of the Week CAR Treg Cells Mediate Linked Suppression and Infectious Tolerance in Islet Transplantation in MiceWardell, C., et al. | October 21, 2025Islet transplantation represents an attractive therapeutic approach for type 1 diabetes; however, it can also…karnottOctober 21, 2025 Read More
Publications of the Week Randomized, Double-Blind, Placebo-Controlled Phase 2A Study Assessing the Efficacy and Safety of Felzartamab for IgA NephropathyFloege, J., et al. | October 15, 2025Felzartamab is a fully human anti-CD38 monoclonal antibody under investigation for treatment of IgA nephropathy…karnottOctober 15, 2025 Read More