Publications of the Week In Mouse and In Vitro Models, Bowel Preparation Promotes Pathogen Colonization, Translocation, and Exacerbation of Inflammation Clayton, C., et al. | January 15, 2026 In the United States, an estimated 14 million colonoscopies are performed yearly, each requiring patients…karnottJanuary 15, 2026 Read More
Publications of the Week Tunable Differentiation of Human CD4+ and CD8+ T Cells From Pluripotent Stem Cells Jones, R., et al. | January 13, 2026 Allogeneic T cell therapies are a highly desirable option to circumvent the cost and complexity…karnottJanuary 13, 2026 Read More
Publications of the Week A Direct Role for a Mitochondrial Targeting Sequence in Signalling Stress Yuan, Z., et al. | January 5, 2026 Mitochondrial protein import is required for maintaining organellar function1. Perturbations in this process are associated…karnottJanuary 5, 2026 Read More
Publications of the Week The Fibroblast Epigenome Underlies SS18::SSX-Mediated Transformation in Synovial Sarcoma Hill, L., et al. | December 16, 2025 Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2)…karnottDecember 16, 2025 Read More
Publications of the Week Cryo-Electron Microscopy Reveals Sequential Binding and Activation of Ryanodine Receptors by Statin Triplets Molinarolo, S., et al. | December 8, 2025 Statins are the most prescribed class of drugs and inhibit a key enzyme in the…karnottDecember 8, 2025 Read More
Publications of the Week Molecular and Imaging Biomarker Responses to Brain Mutant HTT Lowering in a Mouse Model of Huntington Disease Caron, N., et al. | December 1, 2025 Therapies targeting mutant huntingtin (mHTT) reduction in the brain hold promise as disease-modifying treatments for…karnottDecember 1, 2025 Read More
Publications of the Week High-Throughput Bioprinting to Produce Micropatterned Neuroepithelial Tissues and Model TSC2-Deficient Brain Malformations Farahani, N., et al. | November 28, 2025 Micropatterning technology to spatially guide the self-assembly of human pluripotent stem cells (hPSCs) into neural…karnottNovember 28, 2025 Read More
Publications of the Week Decoding Amyloid Beta Clearance Systems at Inner Blood–Retina Barrier Using Three-Dimensional Ex Vivo Retinal Imaging in Alzheimer’s Disease Wijesinghe, P., et al. | November 17, 2025 Impaired amyloid beta (Aβ) clearance contributes to sporadic Alzheimer's disease (AD). This study investigated retinal…karnottNovember 17, 2025 Read More
Publications of the Week Cataloging the Potential Functional Diversity of Cacna1e Splice Variants Using Long-Read Sequencing Bhuiyan, S., et al. | November 13, 2025 The degree to which alternative RNA splicing influences the function and structure of voltage gated…karnottNovember 13, 2025 Read More
Publications of the Week Activity-Targeted Metaproteomics Uncovers Rare Syntrophic Bacteria Central To Anaerobic Community Metabolism Friedline, S., et al. | November 7, 2025 Syntrophic microbial consortia can contribute substantially to the activity of anoxic ecosystems but are often…karnottNovember 7, 2025 Read More