Publications of the Week TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule DynamicsMackenzie, I.R., et al. | August 28, 2017The general focus of our UBC Frontotemporal Dementia (FTD) research group is to improve diagnosis…sciencecityAugust 28, 2017 Read More
Publications of the Week Bypassing Drug-Resistance Mechanisms of Prostate Cancer with Small-Molecules That Target Androgen Receptor Chromatin InteractionsDalal, K. and Rennie, P.S., et al. | August 25, 2017We tested our lead anti-AR DBD inhibitor, VPC-14449, on a panel of anti-androgen resistant prostate…sciencecityAugust 25, 2017 Read More
Publications of the Week De Novo Mutations in YWHAG Cause Early-Onset EpilepsyGuella, I. and Farrer, M.J., et al. | August 23, 2017These gene mutations are the latest discovered in epilepsy, and enable a much faster more…sciencecityAugust 23, 2017 Read More
Publications of the Week Near-Atomic Resolution Cryoelectron Microscopy Structure of the 30-Fold Homooligomeric SpoIIIAG Channel Essential to Spore Formation in Bacillus SubtilisZeytuni, N. and Strynadka, N.C., et al. | August 21, 2017Bacterial sporulation allows starving cells to differentiate into metabolically dormant spores that can survive extreme…sciencecityAugust 21, 2017 Read More
Publications of the Week Amyloid Formation Disrupts the Balance between Interleukin-1β and Interleukin-1 Receptor Antagonist in Human IsletsHui, Q. and Marzban, L., et al. | August 18, 2017β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis…sciencecityAugust 18, 2017 Read More
Publications of the Week Systemic Inflammation Combined with Neonatal Cerebellar Hemorrhage Aggravates Long-Term Structural and Functional Outcomes in a Mouse ModelTremblay, S. and Goldowitz, D., et al. | August 17, 2017Infants born preterm are highly susceptible to various environmental stressors during their first few weeks…sciencecityAugust 17, 2017 Read More
Publications of the Week ReMixT: Clone-Specific Genomic Structure Estimation in CancerMcPherson, A.W. and Shah, S.P., et al. | August 15, 2017Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part…sciencecityAugust 15, 2017 Read More
Publications of the Week Circulating Tumor DNA Reveals Clinically-Actionable Somatic Genome of Metastatic Bladder CancerVandekerkhove, G.R. and Wyatt, A.W., et al. | August 14, 2017Exciting new treatment options have recently emerged for metastatic bladder cancer. However, because each patient’s…sciencecityAugust 14, 2017 Read More
Publications of the Week Glycosyl Cations versus Allylic Cations in Spontaneous and Enzymatic HydrolysisDanby, P.M. and Withers, S.G. | August 11, 2017This work has allowed the first direct comparison of fundamental rates of two key classes…sciencecityAugust 11, 2017 Read More
Publications of the Week Can We Predict Protein from mRNA Levels?Fortelny, N. and Freue, G.V.C., et al. | August 9, 2017Recent advances of genomic, proteomic, and metabolomics technologies have stimulated a large body of biomedical…sciencecityAugust 9, 2017 Read More