Publications of the Week Cell-Type and Tissue Specific Transcriptomes of the White Spruce (Picea Glauca) Bark Unmask Fine-Scale Spatial Patterns of Constitutive and Induced Conifer Defense Celedon, J.M. and Bohlmann, J., et al. | September 13, 2017 Plant defenses often involve specialized cells and tissues. In conifers, specialized cells of the bark…sciencecitySeptember 13, 2017 Read More
Publications of the Week Moving towards Precision Urologic Oncology: Targeting Enzalutamide-Resistant Prostate Cancer and Mutated Forms of the Androgen Receptor Using the Novel Inhibitor Darolutamide Borgmann, H. and Gleave M.E., et al | September 11, 2017 The manuscript describes our results of evaluating activity of darolutamide in enzalutamide-resistant CRPC as well…sciencecitySeptember 11, 2017 Read More
Publications of the Week High-Density Lipoproteins Suppress aβ-Induced PBMC Adhesion to Human Endothelial Cells in Bioengineered Vessels and in Monoculture Robert, J. and Wellington, C.L., et al. | September 8, 2017 Alzheimer's Disease (AD), characterized by accumulation of beta-amyloid (Aβ) plaques in the brain, can be…sciencecitySeptember 8, 2017 Read More
Publications of the Week cGAS-STING and Cancer: Dichotomous Roles in Tumor Immunity and Development Ng, K.W. and Lam, W.L., et al. | September 5, 2017 cGMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) sensing has emerged as a key regulator of…sciencecitySeptember 5, 2017 Read More
Publications of the Week Hsp83 Loss Suppresses Proteasomal Activity Resulting in an Upregulation of Caspase-Dependent Compensatory Autophagy Choutka, C. and Gorski, S.M., et al. | September 1, 2017 We utilized the fruitfly model organism, Drosophila melanogaster, to discover novel relationships between two proteins…sciencecitySeptember 1, 2017 Read More
Publications of the Week Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma Robertson, A.G., et al. | August 30, 2017 UVM arises from melanocytes (melanin pigment producing cells) that reside in the uveal tract of…sciencecityAugust 30, 2017 Read More
Publications of the Week REVIEW: Regenerative Medicine and Cell-Based Approaches to Restore Pancreatic Function Ellis, C. and Kieffer, T.J., et al. | August 29, 2017 The pancreas is a complex organ with exocrine and endocrine components. Many pathologies impair exocrine…sciencecityAugust 29, 2017 Read More
Publications of the Week TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics Mackenzie, I.R., et al. | August 28, 2017 The general focus of our UBC Frontotemporal Dementia (FTD) research group is to improve diagnosis…sciencecityAugust 28, 2017 Read More
Publications of the Week Bypassing Drug-Resistance Mechanisms of Prostate Cancer with Small-Molecules That Target Androgen Receptor Chromatin Interactions Dalal, K. and Rennie, P.S., et al. | August 25, 2017 We tested our lead anti-AR DBD inhibitor, VPC-14449, on a panel of anti-androgen resistant prostate…sciencecityAugust 25, 2017 Read More
Publications of the Week De Novo Mutations in YWHAG Cause Early-Onset Epilepsy Guella, I. and Farrer, M.J., et al. | August 23, 2017 These gene mutations are the latest discovered in epilepsy, and enable a much faster more…sciencecityAugust 23, 2017 Read More