Publications of the Week Drug Tolerance and Persistence to EGFR Inhibitor Treatment Are Mediated by an ILK-SFK-YAP Signaling Axis in Lung AdenocarcinomaShi, R., et al. | September 19, 2025This week, we profile a recent publication in Oncogene by Dr. William Lockwood's lab (pictured). Since…karnottSeptember 19, 2025 Read More
Publications of the Week ERBB2/HER2 Alterations in ctDNA and Metachronous Tissues of Patients with Metastatic Urothelial CancerVandekerkhove, G., et al. | September 18, 2025HER2 targeting is increasingly relevant in metastatic urothelial cancer (mUC) because of emerging antibody–drug conjugates,…karnottSeptember 18, 2025 Read More
Publications of the Week Revealing Function-Altering MECP2 Mutations in Individuals With Autism Spectrum Disorder Using Yeast and DrosophilaChen, E., et al. | September 17, 2025Pathogenic variants in MECP2 commonly lead to Rett syndrome, where MECP2's function as a DNA…karnottSeptember 17, 2025 Read More
Publications of the Week Targeted Splicing Approach for Alleviation of a Neurexin 1 Haploinsufficiency ModelLu, H., et al. | September 11, 2025NRXN1 encoding the synaptic organizing protein neurexin 1 (Nrxn1) is among the strongest risk genes…karnottSeptember 11, 2025 Read More
Publications of the Week Human Milk IgA Promotes Normal Immune Development by Limiting Th17-Inducing Erysipelatoclostridium ramosum in the Infant GutDonald, K., et al. | September 4, 2025The infant gut microbiota plays a vital role in immune development. Secretory IgA (SIgA), the…karnottSeptember 4, 2025 Read More
Publications of the Week Biodegradable Polymers with Tertiary Amines Enhance mRNA Delivery of Lipid Nanoparticles via Improved Endosomal EscapeZhao, F., et al. | August 29, 2025Messenger RNA (mRNA)-based therapy has become a promising and scalable approach for treating various diseases,…karnottAugust 29, 2025 Read More
Publications of the Week SIRT1/DNMT3B-Mediated Epigenetic Gene Silencing in Response Tophytoestrogens in Mammary Epithelial CellsMa, Y., et al. | August 28, 2025We performed an integrated analysis of genome-wide DNA methylation and expression datasetsin normal cells and…karnottAugust 28, 2025 Read More
Publications of the Week Artificial Cellulose Derivatives Are Metabolized by Select Human Gut Bacteroidota upon Priming with Common Plant β-GlucansPanwar, D., et al. | August 20, 2025Synthetic ethers of cellulose (β(1,4)-glucan) are widely used in the food and pharmaceutical industry as…karnottAugust 20, 2025 Read More
Publications of the Week The Parkinson’s Drug Benztropine Possesses Histamine Receptor 1-Dependent Host-Directed Antimicrobial Activity Against Mycobacterium tuberculosisSahile, H., et al. | August 12, 2025Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) evade host defence mechanisms to infect and survive…karnottAugust 12, 2025 Read More
Publications of the Week Defining Enteric Bacterial Pathogenesis Using Organoids: Citrobacter rodentium Uses EspC, an Atypical Mucinolytic Protease, to Penetrate Mouse Colonic MucusChen, Y., et al. | August 8, 2025Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they…karnottAugust 8, 2025 Read More