Publications of the Week Identification of an Optimized Receptor-Binding Domain Subunit Vaccine Against SARS-CoV-2Yu, H., et al. | July 28, 2023Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as…pthomsonJuly 28, 2023 Read More
Publications of the Week Bi-Allelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated CancerWang, Y., et al. | July 27, 2023DICER1 is an RNase III enzyme essential for microRNA (miRNA) biogenesis through cleaving pre-miRNA hairpins.…pthomsonJuly 27, 2023 Read More
Publications of the Week Truncated TDP-43 Proteoforms Diagnostic of Frontotemporal Dementia with TDP-43 PathologyForgrave, L. M., et al. | July 21, 2023Biomarkers of TDP-43 pathology are needed to distinguish frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP)…pthomsonJuly 21, 2023 Read More
Publications of the Week Human Milk Oligosaccharides: Potential Therapeutic Aids for Allergic DiseasesTarrant, I., et al. | July 20, 2023Recent findings from infant cohort, animal, and in vitro studies suggest that human milk oligosaccharides (HMOs) found…pthomsonJuly 20, 2023 Read More
Publications of the Week Influence of ADT on B7-H3 Expression during CRPC Progression from Hormone-Naïve Prostate CancerKang, N., et al. | July 14, 2023Androgen deprivation therapy (ADT) is the standard care for advanced prostate cancer (PCa) patients. Unfortunately,…pthomsonJuly 14, 2023 Read More
Publications of the Week An Impedance-Based Chemiresistor for the Real-Time, Simultaneous Detection of Gut Microbiota-Generated Short-Chain Fatty AcidsYavarinasab, A., et al. | July 14, 2023Short-chain fatty acids (SCFAs) are key molecules, produced by gut bacteria in the intestine, that…pthomsonJuly 14, 2023 Read More
Publications of the Week Deletion of Carboxypeptidase E in Beta Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in MiceChen, Y.-C., et al. | July 7, 2023Carboxypeptidase E (CPE) facilitates the conversion of prohormones into mature hormones and is highly expressed…pthomsonJuly 7, 2023 Read More
Publications of the Week Alternative Splicing and Heparan Sulfation Converge on Neurexin-1 to Control Glutamatergic Transmission and Autism-Related BehaviorsLu, H., et al. | July 7, 2023Neurexin synaptic organizing proteins are central to a genetic risk pathway in neuropsychiatric disorders. Neurexins…pthomsonJuly 7, 2023 Read More
Publications of the Week Optimizing the Number of Variants Tracked to Follow Disease Burden with Circulating Tumour DNA Assays in Metastatic Colorectal CancerBoutin, M., et al. | June 30, 2023The number of somatic mutations detectable in circulating tumor DNA (ctDNA) is highly heterogeneous in…pthomsonJune 30, 2023 Read More
Publications of the Week Deciphering the Biosynthesis of a Novel Lipid in Mycobacterium tuberculosis Expands the Known Roles of the Nitroreductase SuperfamilyGrigg, J. C., et al. | June 27, 2023Mycobacterium tuberculosis’s (Mtb) success as a pathogen is due in part to its sophisticated lipid…pthomsonJune 27, 2023 Read More