Publications of the Week A Secreted Tapasin Isoform Impairs Cytotoxic T Lymphocyte Recognition by Disrupting Exogenous MHC Class I Antigen PresentationSeipp, R., et al. | April 10, 2025Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC)…karnottApril 10, 2025 Read More
Publications of the Week Proteomics and Personalized PDX Models Identify Treatment for a Progressive Malignancy Within an Actionable TimeframeBarnabas, G., et al. | April 8, 2025Genomics has transformed the diagnostic landscape of pediatric malignancies by identifying and integrating actionable features…karnottApril 8, 2025 Read More
Publications of the Week Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE TransdifferentiationWang, Y., et al. | April 4, 2025Prostate cancer remains one of the leading causes of cancer-related deaths among men, and understanding…karnottApril 4, 2025 Read More
Publications of the Week 5′-S-(3-Aminophenyl)-5′-Thioadenosine, a Novel Chemoprotective Agent for Reducing Toxic Side Effects of Fluorouracil in Treatment of MTAP-Deficient CancersZhang, S., et al. | March 27, 2025Nucleobase analogue (NBA) drugs, such as 5-fluorouracil (5-FU), are effective chemotherapeutics, but their clinical use…karnottMarch 27, 2025 Read More
Publications of the Week Sanfetrinem, an Oral β-Lactam Antibiotic Repurposed for the Treatment of TuberculosisRamón-García, S., et al. | March 24, 2025This week, we profile a recent publication in Drug Resistance Updates by Dr. Santiago Ramón-García…karnottMarch 24, 2025 Read More
Publications of the Week Type-2 Innate Signals Are Dispensable for Skeletal Muscle Regeneration and Pathology Linked to Duchenne Muscular DystrophyMessing, M., et al. | March 18, 2025Immune responses play an integral role in skeletal muscle regeneration. In the genetically inherited muscle…karnottMarch 18, 2025 Read More
Publications of the Week Epstein-Barr Virus Infection Promotes T Cell Dysregulation in a Humanized Mouse Model of Multiple SclerosisAllanach, J., et al. | March 13, 2025Latent infection with Epstein-Barr virus (EBV) is a strong risk factor for the development of…karnottMarch 13, 2025 Read More
Publications of the Week Brain Pericytes and Perivascular Fibroblasts Are Stromal Progenitors With Dual Functions in Cerebrovascular Regeneration After StrokeBernier, L., et al. | March 10, 2025Functional revascularization is key to stroke recovery and requires remodeling and regeneration of blood vessels…karnottMarch 10, 2025 Read More
Publications of the Week Single Cell Approaches Define Neural Stem Cell Niches and Identify Microglial Ligands That Can Enhance Precursor-Mediated OligodendrogenesisWillis, A., et al. | March 6, 2025Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the…karnottMarch 6, 2025 Read More
Publications of the Week Melatonin Supplementation and Oxidative DNA Damage Repair Capacity Among Night Shift Workers: A Randomised Placebo-Controlled TrialZanif, U., et al. | March 4, 2025A decreased ability to repair oxidative DNA damage, due to melatonin suppression, is a compelling…karnottMarch 4, 2025 Read More