Publications of the Week Stereotactic Ablative Radiation for Oligoprogressive Cancers: Results of the Randomized Phase 2 STOP Trial Schellenberg, D., et al. | January 24, 2025 We enrolled patients with 1 to 5 metastases progressing on systemic therapy, and after stratifying…karnottJanuary 24, 2025 Read More
Publications of the Week Biochemical and Structural Characterization of Rab3GAP Reveals Insights into Rab18 Nucleotide Exchange Activity Fairlie, G., et al. | January 13, 2025 The heterodimeric Rab3GAP complex is a guanine nucleotide exchange factor (GEF) for the Rab18 GTPase…karnottJanuary 13, 2025 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined Niches Stankiewicz, L., et al. | January 10, 2025 Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions…karnottJanuary 10, 2025 Read More
Publications of the Week SARS-CoV-2 3CLpro (Main Protease) Regulates Caspase Activation of Gasdermin-D/E Pores Leading to Secretion and Extracellular Activity of 3CLpro Grin, P., et al. | January 6, 2025 SARS-CoV-2 3C-like protease (3CLpro or Mpro) cleaves the SARS-CoV-2 polyprotein and >300 intracellular host proteins to…karnottJanuary 6, 2025 Read More
Publications of the Week Tracking the Gene Expression Programs and Clonal Relationships That Underlie Mast, Myeloid, and T Lineage Specification from Stem Cells Michaels, Y., et al. | December 17, 2024 T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer.…karnottDecember 17, 2024 Read More
Publications of the Week Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles Is Compatible with Blood Banking Practices Strong, C., et al. | December 10, 2024 Platelets contribute to a variety of physiological processes, including inflammation, sepsis, and cancer. However, because…karnottDecember 10, 2024 Read More
Publications of the Week Immune Regulatory and Anti-Resorptive Activities of Tanshinone IIA Sulfonate Attenuates Rheumatoid Arthritis in Mice Panwar, P., et al. | December 9, 2024 Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and painful joint destruction.…karnottDecember 9, 2024 Read More
Publications of the Week Transcriptional Coactivator MED15 Is Required for Beta Cell Maturation Kadhim, A., et al. | December 5, 2024 Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors…karnottDecember 5, 2024 Read More
Publications of the Week The Glycosyltransferase ST3GAL4 Drives Immune Evasion in Acute Myeloid Leukemia by Synthesizing Ligands for the Glyco-Immune Checkpoint Receptor Siglec-9 Krishnamoorthy, V., et al. | December 3, 2024 Immunotherapy has demonstrated promise as a treatment for acute myeloid leukemia (AML). However, there is…karnottDecember 3, 2024 Read More
Publications of the Week Microbial Intestinal Dysbiosis Drives Long-Term Allergic Susceptibility by Sculpting an ILC2-B1 Cell-Innate IgE Axis Kabil, A., et al. | November 28, 2024 The abundance and diversity of intestinal commensal bacteria influence systemic immunity with impact on disease…karnottNovember 28, 2024 Read More