Publications of the Week Exploring B7-H4’s Role in Prostate Cancer Dormancy After Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities Kang, N., et al. | April 14, 2025 Prostate cancer is mainly managed with androgen deprivation therapy (ADT), but this often leads to…karnottApril 14, 2025 Read More
Publications of the Week A Secreted Tapasin Isoform Impairs Cytotoxic T Lymphocyte Recognition by Disrupting Exogenous MHC Class I Antigen Presentation Seipp, R., et al. | April 10, 2025 Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC)…karnottApril 10, 2025 Read More
Publications of the Week Proteomics and Personalized PDX Models Identify Treatment for a Progressive Malignancy Within an Actionable Timeframe Barnabas, G., et al. | April 8, 2025 Genomics has transformed the diagnostic landscape of pediatric malignancies by identifying and integrating actionable features…karnottApril 8, 2025 Read More
Publications of the Week Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation Wang, Y., et al. | April 4, 2025 Prostate cancer remains one of the leading causes of cancer-related deaths among men, and understanding…karnottApril 4, 2025 Read More
Publications of the Week 5′-S-(3-Aminophenyl)-5′-Thioadenosine, a Novel Chemoprotective Agent for Reducing Toxic Side Effects of Fluorouracil in Treatment of MTAP-Deficient Cancers Zhang, S., et al. | March 27, 2025 Nucleobase analogue (NBA) drugs, such as 5-fluorouracil (5-FU), are effective chemotherapeutics, but their clinical use…karnottMarch 27, 2025 Read More
Publications of the Week Sanfetrinem, an Oral β-Lactam Antibiotic Repurposed for the Treatment of Tuberculosis Ramón-García, S., et al. | March 24, 2025 This week, we profile a recent publication in Drug Resistance Updates by Dr. Santiago Ramón-García…karnottMarch 24, 2025 Read More
Publications of the Week Type-2 Innate Signals Are Dispensable for Skeletal Muscle Regeneration and Pathology Linked to Duchenne Muscular Dystrophy Messing, M., et al. | March 18, 2025 Immune responses play an integral role in skeletal muscle regeneration. In the genetically inherited muscle…karnottMarch 18, 2025 Read More
Publications of the Week Epstein-Barr Virus Infection Promotes T Cell Dysregulation in a Humanized Mouse Model of Multiple Sclerosis Allanach, J., et al. | March 13, 2025 Latent infection with Epstein-Barr virus (EBV) is a strong risk factor for the development of…karnottMarch 13, 2025 Read More
Publications of the Week Brain Pericytes and Perivascular Fibroblasts Are Stromal Progenitors With Dual Functions in Cerebrovascular Regeneration After Stroke Bernier, L., et al. | March 10, 2025 Functional revascularization is key to stroke recovery and requires remodeling and regeneration of blood vessels…karnottMarch 10, 2025 Read More
Publications of the Week Single Cell Approaches Define Neural Stem Cell Niches and Identify Microglial Ligands That Can Enhance Precursor-Mediated Oligodendrogenesis Willis, A., et al. | March 6, 2025 Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the…karnottMarch 6, 2025 Read More