Publications of the Week Homologous Recombination Deficiency Signatures in Gastrointestinal and Thoracic Cancers Correlate with Platinum Therapy DurationTsang, E. S., et al. | March 29, 2023There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this…pthomsonMarch 29, 2023 Read More
Publications of the Week RNA Modifications in Hematological MalignanciesJin, Z., et al. | March 23, 2023RNA modifications play an important role in various cancers including blood cancers by controlling gene…pthomsonMarch 23, 2023 Read More
Publications of the Week Deconvolution of Clinical Variance in CAR-T Cell Pharmacology and ResponseKirouac, D., et al. | March 20, 2023Read the Publication This week we profile a recent publication in Nature Biotechnology from Dr.…pthomsonMarch 20, 2023 Read More
Publications of the Week Targeting Regulatory T Cell Metabolism in Disease: Novel Therapeutic OpportunitiesHalvorson, T., et al. | March 17, 2023Regulatory T cells (Tregs) are essential for immune homeostasis and suppression of pathological autoimmunity but…pthomsonMarch 17, 2023 Read More
Publications of the Week Activation of β-Catenin in Mesenchymal Progenitors Leads to Muscle Mass LossKajabadi, M., et al. | March 15, 2023Loss of muscle mass is a common manifestation of chronic disease. We find the canonical…pthomsonMarch 15, 2023 Read More
Publications of the Week Control of Focal Adhesion Kinase Activation by RUNX1-Regulated miRNAs in High-Risk AMLAkhade, V. S., et al. | March 9, 2023The major focus of Dr. Aly Karsan's lab is to understand the mechanisms of refractoriness…pthomsonMarch 9, 2023 Read More
Publications of the Week Circulating Tumor DNA: Toward Evolving the Clinical Paradigm of Pancreatic Ductal AdenocarcinomaTopham, J. T., et al. | March 8, 2023Over a decade of sequencing-based genomics research has unveiled a diverse somatic mutation landscape across…pthomsonMarch 8, 2023 Read More
Publications of the Week In Silico Discovery of Small Molecules for Efficient Stem Cell Differentiation into Definitive EndodermNovakovsky, G., et al. | March 3, 2023Over 400 million people worldwide live with diabetes, a chronic disease caused by insulin deficiency…pthomsonMarch 3, 2023 Read More
Publications of the Week Clinical Application of Immune Repertoire Sequencing in Solid Organ TransplantWong, P., et al. | March 2, 2023Measurement of T cell receptor (TCR) or B cell receptor (BCR) gene utilization may be…pthomsonMarch 2, 2023 Read More
Publications of the Week A Luciferase Reporter Mouse Model to Optimize In Vivo Gene Editing Validated by Lipid Nanoparticledelivery of Adenine Base EditorsYu, S.-Y., et al. | February 23, 2023The rapid development of CRISPR genome editing technology has provided the potential to treat genetic…pthomsonFebruary 23, 2023 Read More