Publications of the Week Tracking the Gene Expression Programs and Clonal Relationships That Underlie Mast, Myeloid, and T Lineage Specification from Stem Cells Michaels, Y., et al. | December 17, 2024 T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer.…karnottDecember 17, 2024 Read More
Publications of the Week Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles Is Compatible with Blood Banking Practices Strong, C., et al. | December 10, 2024 Platelets contribute to a variety of physiological processes, including inflammation, sepsis, and cancer. However, because…karnottDecember 10, 2024 Read More
Publications of the Week Immune Regulatory and Anti-Resorptive Activities of Tanshinone IIA Sulfonate Attenuates Rheumatoid Arthritis in Mice Panwar, P., et al. | December 9, 2024 Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and painful joint destruction.…karnottDecember 9, 2024 Read More
Publications of the Week Transcriptional Coactivator MED15 Is Required for Beta Cell Maturation Kadhim, A., et al. | December 5, 2024 Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors…karnottDecember 5, 2024 Read More
Publications of the Week The Glycosyltransferase ST3GAL4 Drives Immune Evasion in Acute Myeloid Leukemia by Synthesizing Ligands for the Glyco-Immune Checkpoint Receptor Siglec-9 Krishnamoorthy, V., et al. | December 3, 2024 Immunotherapy has demonstrated promise as a treatment for acute myeloid leukemia (AML). However, there is…karnottDecember 3, 2024 Read More
Publications of the Week Microbial Intestinal Dysbiosis Drives Long-Term Allergic Susceptibility by Sculpting an ILC2-B1 Cell-Innate IgE Axis Kabil, A., et al. | November 28, 2024 The abundance and diversity of intestinal commensal bacteria influence systemic immunity with impact on disease…karnottNovember 28, 2024 Read More
Publications of the Week Luminal Breast Epithelial Cells of BRCA1 or BRCA2 Mutation Carriers and Noncarriers Harbor Common Breast Cancer Copy Number Alterations Williams, M., et al. | November 27, 2024 The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium and their…karnottNovember 27, 2024 Read More
Publications of the Week Antithrombotic Coating with Sheltered Positive Charges Prevents Contact Activation by Controlling Factor XII–Biointerface Binding Ji, H., et al. | November 18, 2024 Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices.…karnottNovember 18, 2024 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined Niches Stankiewicz, L., et al. | November 15, 2024 This week, we profile a recent publication in Developmental Cell by Dr. Fabio Rossi (pictured)…karnottNovember 15, 2024 Read More
Publications of the Week Predictive Gene Expression Signature Diagnoses Neonatal Sepsis Before Clinical Presentation An, A., et al. | November 5, 2024 Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There…karnottNovember 5, 2024 Read More