Publications of the Week A Community Effort to Optimize Sequence-Based Deep Learning Models of Gene Regulation Muntakim Rafi, A., et al. | October 30, 2024 A systematic evaluation of how model architectures and training strategies impact genomics model performance is…karnottOctober 30, 2024 Read More
Publications of the Week Transient CAR T Cells with Specificity to Oncofetal Glycosaminoglycans in Solid Tumors Khazamipour, N., et al. | October 25, 2024 Glycosaminoglycans are often deprioritized as targets for synthetic immunotherapy due to the complexity of glyco-epitopes…karnottOctober 25, 2024 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined Niches Stankiewicz, L., et al. | October 14, 2024 Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions…karnottOctober 14, 2024 Read More
Publications of the Week Discovery of Benzo[c]phenanthridine Derivatives with Potent Activity Against Multidrug-Resistant Mycobacterium tuberculosis Liang, Y., et al. | October 11, 2024 Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis (TB), is the leading cause of bacterial disease-related…karnottOctober 11, 2024 Read More
Publications of the Week Genetic Engineering of Megakaryocytes from Blood Progenitor Cells Using mRNA Lipid Nanoparticles Leung, J., et al. | October 4, 2024 Platelets are an essential component of hemorrhage control and management, and engineering platelets to express…karnottOctober 4, 2024 Read More
Publications of the Week Immune Regulatory and Anti-Resorptive Activities of Tanshinone IIA Sulfonate Attenuates Rheumatoid Arthritis in Mice Panwar, P., et al. | September 27, 2024 Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and painful joint destruction.…karnottSeptember 27, 2024 Read More
Publications of the Week Protein Is Expressed in All Major Organs After Intravenous Infusion of mRNA-Lipid Nanoparticles in Swine Ferraresso, F., et al. | September 19, 2024 In vivo delivery of mRNA is promising for the study of gene expression and the treatment…karnottSeptember 19, 2024 Read More
Publications of the Week Single Cell Glucose-Stimulated Insulin Secretion Assay Using Nanowell-in-Microwell Plates Jang, D., et al. | September 13, 2024 Pancreatic β cells secrete insulin in response to elevated levels of glucose. Stem cell derived…karnottSeptember 13, 2024 Read More
Publications of the Week Gelsolin Regulates Receptor-Mediated and Fluid-Phase Endocytosis in Platelets Paul, M., et al. | September 5, 2024 Endocytosis is the process by which platelets incorporate extracellular molecules into their secretory granules. Endocytosis…karnottSeptember 5, 2024 Read More
Publications of the Week Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices Strong, C., et al. | September 2, 2024 Platelets contribute to a variety of physiological processes including inflammation, sepsis and cancer. However, due…karnottSeptember 2, 2024 Read More