Publications of the Week A MYCN-Independent Mechanism Mediating Secretome Reprogramming and Metastasis in MYCN-Amplified NeuroblastomaZhang, H., et al. | August 24, 2023MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) and predicts poor prognosis. However,…pthomsonAugust 24, 2023 Read More
Publications of the Week A High-Throughput Screening Platform for Enzymes Active on Mucin-Type O-GlycoproteinsWardman, J. F., et al. | August 22, 2023Mucin-type O-glycosylation is a post-translational modification present at the interface between cells where it has…pthomsonAugust 22, 2023 Read More
Publications of the Week Cleavage of 14-3-3ε by the Enteroviral 3C Protease Dampens RIG-I-Mediated Antiviral SignalingAndrews, D. D. T., et al. | August 15, 2023Viruses have evolved diverse strategies to evade the host innate immune response and promote infection.…pthomsonAugust 15, 2023 Read More
Publications of the Week A Novel Class of Broad-Spectrum Active-Site-Directed 3C-Like Protease Inhibitors with Nanomolar Antiviral Activity against highly Immune-Evasive SARS-CoV-2 Omicron SubvariantsPérez-Vargas, J., et al. | August 14, 2023Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly…pthomsonAugust 14, 2023 Read More
Publications of the Week ASCL1 Is Activated Downstream of the ROR2/CREB Signaling Pathway to Support Lineage Plasticity in Prostate CancerTabrizian, N., et al. | August 11, 2023Lineage plasticity is a form of therapy-induced drug resistance. In prostate cancer, androgen receptor (AR)…pthomsonAugust 11, 2023 Read More
Publications of the Week DNA-PK Inhibition Extends the Therapeutic Effects of Top2 Poisoning to Non-Proliferating Cells, Increasing Activity at a CostWant, T., et al. | August 10, 2023Type II topoisomerase (Top2) poisoning therapy is used to treat a broad range of cancers…pthomsonAugust 10, 2023 Read More
Publications of the Week Eras of Designer Tregs: Harnessing Synthetic Biology for Immune SuppressionTuomela, K., et al. | August 4, 2023Since their discovery, CD4+CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly established as a critical cell…pthomsonAugust 4, 2023 Read More
Publications of the Week Meis1 Establishes the Pre-Hemogenic Endothelial State Prior to Runx1 ExpressionCoulombe, P., et al. | August 2, 2023Hematopoietic stem and progenitor cells (HSPCs) originate from an endothelial-to-hematopoietic transition (EHT) during embryogenesis. Characterization…pthomsonAugust 2, 2023 Read More
Publications of the Week Identification of an Optimized Receptor-Binding Domain Subunit Vaccine Against SARS-CoV-2Yu, H., et al. | July 28, 2023Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as…pthomsonJuly 28, 2023 Read More
Publications of the Week Bi-Allelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated CancerWang, Y., et al. | July 27, 2023DICER1 is an RNase III enzyme essential for microRNA (miRNA) biogenesis through cleaving pre-miRNA hairpins.…pthomsonJuly 27, 2023 Read More