Publications of the Week A Microfluidic Platform Integrating Functional Vascularized Organoids-on-ChipQuintard, C., et al. | March 5, 2024The development of vascular networks in microfluidic chips is crucial for the long-term culture of…karnottMarch 5, 2024 Read More
Publications of the Week Prediction of Plasma ctDNA Fraction and Prognostic Implications of Liquid Biopsy in Advanced Prostate CancerFonseca, N., et al. | March 4, 2024No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction…karnottMarch 4, 2024 Read More
Publications of the Week Single-Cell Assessment of Primary and Stem Cell-Derived Human Trophoblast Organoids As Placenta-Modeling PlatformsShannon, M., et al. | February 28, 2024This week we profile a recent publication in Developmental Cell by Matthew Shannon (pictured, right)…karnottFebruary 28, 2024 Read More
Publications of the Week The Discovery of New Sentinels on the Immune Watchtower for CancerXia, C., et al. | February 27, 2024Approximately 2 in 5 Canadians will be diagnosed with cancer in their lifetime, and yet we…karnottFebruary 27, 2024 Read More
Publications of the Week A Tumor-Restricted Glycoform of Podocalyxin Is a Highly Selective Marker of Immunologically Cold High-Grade Serous Ovarian CarcinomaBrassard, J., et al. | February 23, 2024Targeted-immunotherapies such as antibody-drug conjugates (ADC), chimeric antigen receptor (CAR) T cells or bispecific T-cell…karnottFebruary 23, 2024 Read More
Publications of the Week Lipid Nanoparticles and siRNA Targeting Plasminogen Provide Lasting Inhibition of Fibrinolysis in Mouse and Dog Models of Hemophilia AStrilchuk, A., et al. | February 23, 2024Antifibrinolytic drugs are used extensively for on-demand treatment of severe acute bleeding. Controlling fibrinolysis may…karnottFebruary 23, 2024 Read More
Publications of the Week Phosphorylation of RyR2 Simultaneously Expands the Dyad and Rearranges the TetramersAsghari, P., et al. | February 21, 2024We have previously demonstrated that type II ryanodine receptors (RyR2) tetramers can be rapidly rearranged…karnottFebruary 21, 2024 Read More
Publications of the Week Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug ConjugatesPetersen, M., et al. | February 14, 2024In recent years, the field of antibody drug conjugates (ADCs) has seen a resurgence, largely…karnottFebruary 14, 2024 Read More
Publications of the Week A Longitudinal Single-Cell Atlas of Treatment Response in Pediatric AMLLambo, S., et al. | February 7, 2024Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular composition, driver alterations and prognosis.…karnottFebruary 7, 2024 Read More
Publications of the Week Spatially Resolved Tumor Microenvironment Predicts Treatment Outcomes in Relapsed/Refractory Hodgkin LymphomaAoki, T., et al. | January 31, 2024About a third of patients with relapsed or refractory classic Hodgkin lymphoma (r/r CHL) succumb…karnottJanuary 31, 2024 Read More