Publications of the Week A 3D Human iPSC-Derived Multi-Cell Type Neurosphere System to Model Cellular Responses to Chronic AmyloidosisWendt, S., et al. | April 30, 2025Alzheimer’s disease (AD) is characterized by progressive amyloid beta (Aβ) deposition in the brain, with…karnottApril 30, 2025 Read More
Publications of the Week Polyphosphatases Have a Polyphosphate-Independent Influence on the Virulence of Cryptococcus neoformansBhalla, K., et al. | April 24, 2025Cryptococcus neoformans, an invasive basidiomycete fungal pathogen, causes one of the most prevalent, life-threatening diseases…karnottApril 24, 2025 Read More
Publications of the Week Antithrombotic Coating With Sheltered Positive Charges Prevents Contact Activation by Controlling Factor XII–Biointerface BindingJi, H., et al. | April 16, 2025Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices.…karnottApril 16, 2025 Read More
Publications of the Week Exploring B7-H4’s Role in Prostate Cancer Dormancy After Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic OpportunitiesKang, N., et al. | April 14, 2025Prostate cancer is mainly managed with androgen deprivation therapy (ADT), but this often leads to…karnottApril 14, 2025 Read More
Publications of the Week A Secreted Tapasin Isoform Impairs Cytotoxic T Lymphocyte Recognition by Disrupting Exogenous MHC Class I Antigen PresentationSeipp, R., et al. | April 10, 2025Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC)…karnottApril 10, 2025 Read More
Publications of the Week Proteomics and Personalized PDX Models Identify Treatment for a Progressive Malignancy Within an Actionable TimeframeBarnabas, G., et al. | April 8, 2025Genomics has transformed the diagnostic landscape of pediatric malignancies by identifying and integrating actionable features…karnottApril 8, 2025 Read More
Publications of the Week Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE TransdifferentiationWang, Y., et al. | April 4, 2025Prostate cancer remains one of the leading causes of cancer-related deaths among men, and understanding…karnottApril 4, 2025 Read More
Publications of the Week 5′-S-(3-Aminophenyl)-5′-Thioadenosine, a Novel Chemoprotective Agent for Reducing Toxic Side Effects of Fluorouracil in Treatment of MTAP-Deficient CancersZhang, S., et al. | March 27, 2025Nucleobase analogue (NBA) drugs, such as 5-fluorouracil (5-FU), are effective chemotherapeutics, but their clinical use…karnottMarch 27, 2025 Read More
Publications of the Week Sanfetrinem, an Oral β-Lactam Antibiotic Repurposed for the Treatment of TuberculosisRamón-García, S., et al. | March 24, 2025This week, we profile a recent publication in Drug Resistance Updates by Dr. Santiago Ramón-García…karnottMarch 24, 2025 Read More
Publications of the Week Type-2 Innate Signals Are Dispensable for Skeletal Muscle Regeneration and Pathology Linked to Duchenne Muscular DystrophyMessing, M., et al. | March 18, 2025Immune responses play an integral role in skeletal muscle regeneration. In the genetically inherited muscle…karnottMarch 18, 2025 Read More