Publications of the Week Fluvastatin for Lowering Lipids Adams, S.P. and Wright, J.M., et al. | March 21, 2018 Fluvastatin is thought to be the least potent statin on the market, however, the dose-related…sciencecityMarch 21, 2018 Read More
Publications of the Week Systemic Study of Solvent-Assisted Active Loading of Gambogic Acid Into Liposomes and Its Formulation Optimization for Improved Delivery Tang, W.L. and Li, S.D., et al. | March 19, 2018 The solvent-assisted active loading technology (SALT) was developed for encapsulating a water insoluble weak base…sciencecityMarch 19, 2018 Read More
Publications of the Week Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer Ci, X. and Wang, Y., et al. | March 16, 2018 NEPC research by Dr. Yuzhuo Wang group has led to the development of a unique…sciencecityMarch 16, 2018 Read More
Publications of the Week Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461 Prosser, K.E. and Walsby, C.J., et al. | March 12, 2018 Low aqueous solubility is a major barrier to the clinical application of otherwise promising drug…sciencecityMarch 12, 2018 Read More
Publications of the Week HIC1 Links Retinoic Acid Signalling to Group 3 Innate Lymphoid Cell-Dependent Regulation of Intestinal Immunity and Homeostasis Burrows, K. and Zaph, C., et al. | March 9, 2018 The intestinal immune system must be able to respond to a wide variety of infectious…sciencecityMarch 9, 2018 Read More
Publications of the Week Somatic IL4R Mutations in Primary Mediastinal Large B-Cell Lymphoma Lead to Constitutive JAK-STAT Signaling Activation Vigano, E. and Steidl, C., et al. | March 8, 2018 Primary mediastinal large B cell lymphoma (PMBCL) is a distinct subtype of diffuse large B…sciencecityMarch 8, 2018 Read More
Publications of the Week N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection Jagdeo, J.M. and Jan, E., et al. | March 5, 2018 RNA viruses typically encode a limited number of proteins, yet during infection, these viral proteins…sciencecityMarch 5, 2018 Read More
Publications of the Week Non-Canonical Activation of Hedgehog in Prostate Cancer Cells Mediated by the Interaction of Transcriptionally Active Androgen Receptor Proteins with Gli3 Li, N. and Buttyan, R., et al. | February 28, 2018 Hedgehog is a cell signalling pathway needed for normal embryonic development. Hyperactive Hedgehog in adult…sciencecityFebruary 28, 2018 Read More
Publications of the Week PP2A Inhibition Sensitizes Cancer Stem Cells to ABL Tyrosine Kinase Inhibitors in BCR-ACL+ Human Leukemia Lai, D. and Jiang, X., et al. | February 26, 2018 We have uncovered protein phosphatase 2A (PP2A) as a critical therapeutic target in drug-resistant blood…sciencecityFebruary 26, 2018 Read More
Publications of the Week CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function Canning, P. and Leroux, M.R., et al. | February 22, 2018 Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of…sciencecityFebruary 22, 2018 Read More