Publications of the Week Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461 Prosser, K.E. and Walsby, C.J., et al. | March 12, 2018 Low aqueous solubility is a major barrier to the clinical application of otherwise promising drug…sciencecityMarch 12, 2018 Read More
Publications of the Week HIC1 Links Retinoic Acid Signalling to Group 3 Innate Lymphoid Cell-Dependent Regulation of Intestinal Immunity and Homeostasis Burrows, K. and Zaph, C., et al. | March 9, 2018 The intestinal immune system must be able to respond to a wide variety of infectious…sciencecityMarch 9, 2018 Read More
Publications of the Week Somatic IL4R Mutations in Primary Mediastinal Large B-Cell Lymphoma Lead to Constitutive JAK-STAT Signaling Activation Vigano, E. and Steidl, C., et al. | March 8, 2018 Primary mediastinal large B cell lymphoma (PMBCL) is a distinct subtype of diffuse large B…sciencecityMarch 8, 2018 Read More
Publications of the Week N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection Jagdeo, J.M. and Jan, E., et al. | March 5, 2018 RNA viruses typically encode a limited number of proteins, yet during infection, these viral proteins…sciencecityMarch 5, 2018 Read More
Publications of the Week Non-Canonical Activation of Hedgehog in Prostate Cancer Cells Mediated by the Interaction of Transcriptionally Active Androgen Receptor Proteins with Gli3 Li, N. and Buttyan, R., et al. | February 28, 2018 Hedgehog is a cell signalling pathway needed for normal embryonic development. Hyperactive Hedgehog in adult…sciencecityFebruary 28, 2018 Read More
Publications of the Week PP2A Inhibition Sensitizes Cancer Stem Cells to ABL Tyrosine Kinase Inhibitors in BCR-ACL+ Human Leukemia Lai, D. and Jiang, X., et al. | February 26, 2018 We have uncovered protein phosphatase 2A (PP2A) as a critical therapeutic target in drug-resistant blood…sciencecityFebruary 26, 2018 Read More
Publications of the Week CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function Canning, P. and Leroux, M.R., et al. | February 22, 2018 Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of…sciencecityFebruary 22, 2018 Read More
Publications of the Week Harnessing Innate Lung Anti-Cancer Effector Functions with a Novel Bacterial-Derived Immunotherapy Bazett, M. and Mullins, D.W., et al. | February 20, 2018 Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been…sciencecityFebruary 20, 2018 Read More
Publications of the Week Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength Ge, Y. and Craig, A.M., et al. | February 19, 2018 In contrast with numerous studies of glutamate receptor-associated proteins and their involvement in the modulation…sciencecityFebruary 19, 2018 Read More
Publications of the Week Heterogeneity Within the Frontoparietal Control Network and Its Relationship to the Default and Dorsal Attention Networks Dixon, M.L. and Christoff, K., et al. | February 16, 2018 The frontoparietal control network (FPCN) plays a central role in executive control. It has been…sciencecityFebruary 16, 2018 Read More