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Lipid and RNA Nanomedicines to Control Bleeding and Thrombosis
September 21, 2021
Dr. Christian Kastrup
Associate Professor in the Michael Smith Laboratories and Department of Biochemistry & Molecular Biology at the University of British Columbia; member of the Centre for Blood Research and the School of Biomedical Engineering
Tuesday 21 September 2021
10:00 – 11:00 am PDT | 1:00 – 2:00 pm EDT
This lecture will be delivered online using Zoom
Blood coagulation is necessary to stop bleeds, but an imbalance of the enzymes that form, inhibit and degrade blood clots can lead to bleeding disorders, failure to stop severe hemorrhage after injury, or formation of thromboses. Gene therapy, using RNA and lipid nanoparticles, can be used to modulate the concentration of these enzymes and correct any imbalance. This talk will highlight the applicability of RNA and lipid nanoparticles to control the expression of endogenous and exogenous proteins in the liver and in platelets, for the goal of creating useful therapies for trauma, rare bleeding disorders, and thrombosis.
Dr. Christian Kastrup did his postdoctoral fellowship in at MIT, where he specialized in engineering biomaterials for cardiovascular drug delivery. He received his PhD at the University of Chicago, where he specialized in chemical biology, microfluidics, and blood coagulation. His lab at UBC utilizes biochemical engineering to solve problems related to hemostasis and hemorrhage. They investigate, utilize, and mimic the biochemistry and biophysical dynamics of blood coagulation to create innovative materials that perform new functions inside of blood vessels, and work to develop treatments for severe hemorrhage.
Dr. Kastrup has received many accolades, the most recent one being the Sir Major Banting Award from the True Patriot Love Foundation. He is the Chief Scientific Officer of CoMotion Drug Delivery Systems, Inc., which is working to develop hemostatic agents for severe combat and surgical hemorrhage.