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White Mold Fungi Split Their Genome Across Several Nuclei, with Implications for Future Gene Editing

By October 6, 2025No Comments

Genomes contain the complete library of information required to build and maintain a living organism — the figurative blueprints of life. In eukaryotes, genomes are stored in the nuclei, where they are organized into chromosomes. A eukaryote is an organism whose cells have a nucleus surrounded by a membrane: plants, animals, fungi and many microbes are eukaryotes.
The human genome, for example, is organized in 23 chromosomes, each containing a portion of the complete genetic code. Until recently, it has always been assumed that each nucleus contains at least a complete set of chromosomes, and thus the “one nucleus, one full genome” rule.

However, our research has revealed that in two species of fungi, their genomes can be split across multiple nuclei, with each nucleus receiving only part of the total chromosomes.