Formalin fixation of paraffin-embedded tissue samples is widely used to preserve tissue for clinical investigation. However, the integrity of the genomic material extracted from such samples is not always preserved, and it can lead to errors in downstream sequencing analysis, including somatic variant calling. GSC scientists conducted a comprehensive comparison of variant caller performance and established a bioinformatics-based approach to…
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Alpha Cognition Inc. (TSX-V: ACOG) (OTCQB: ACOGF) (“Alpha Cognition”, or the “Company”), a biopharmaceutical company committed to developing novel therapies for people with debilitating neurodegenerative disorders, today announced positive results from its pivotal bioequivalence study with ALPHA-1062, a proprietary, delayed release oral tablet formulation in development for the treatment of mild to moderate Alzheimer’s Disease (AD).
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Algernon Pharmaceuticals Inc. (the “Company” or “Algernon”) (CSE: AGN) (FRANKFURT: AGWO) (OTCQB: AGNPF), a Canadian clinical stage pharmaceutical development company, is pleased to announce that it has been issued a patent from the Canadian Intellectual Property Office (“CIPO”), No. 3101853, for the treatment of interstitial lung disease with NP-120 (“Ifenprodil”), entitled “Compositions and Methods for Treating Idiopathic Pulmonary Fibrosis.”
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How a Young Scientist Turned His Research Career into Community Outreach

Ryan Tomm never expected to end up in the lab. He just knew he wanted to help his community, the Cree Nation in Northern Alberta. Maybe by working as a counsellor, or a psychologist. But neuroscience research turned out to be his path. Now, Tomm is a behavioural neuroscience and psychology PhD candidate at the University of British Columbia. Tomm spoke with BrainFacts.org about…
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Fine-Tuning Fibrin(ogen)

Fibrinogen plays multi-faceted roles in many processes that are essential for the maintenance of human health and the prevention of disease1. The formation of a stable blood clot, for example, relies on thrombin-mediated cleavage of fibrinogen to fibrin1. On the flip side, elevated fibrinogen during inflammation (hyperfibrinogenemia) increases the risk of thrombosis2. Whereas extravascular fibrin(ogen) deposits at sites of tissue…
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Among studies of single cells to bioengineered models of development, Cell Stem Cell has named a phase 1/2 clinical paper by Drs. Adam Ramzy (first author) and Timothy Kieffer (senior author) amongst its reader’s and editors’ top picks from the journal in 2021. In a series of tweets, Cell Stem Cell presented Ramzy and Kieffer’s analysis of year one data from a phase…
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Whole Genome and Transcriptome Analysis Benefits Clinical Cancer Care

The Personalized OncoGenomics Program (POG), co-led by Drs. Janessa Laskin and Marco Marra, is a patient-centric research initiative that uses genomic data to study cancer growth, metastasis and response to treatment. A publication in Annals of Oncology presents clinical data from 570 adult patients with advanced or metastatic cancer enrolled in the program from 2012-2017, the largest report on POG clinical findings to date.
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BC Invests $25M into New School of Biomedical Engineering Facility

Since 2017, the UBC School of Biomedical Engineering offers undergraduate and graduate programs to more than 500 students annually. However, the school currently operates classes and labs in 24 buildings scattered across UBC’s Vancouver campus. UBC is building a new purpose-built facility for the school, aided by this $25 million grant from the Government of British Columbia. The province’s investment…
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Cracking the Code for the Cure to ‘Corn Smut’

At the same time a prized delicacy and a virulent pest, the fungus Ustilago maydis delights epicureans while frazzling farmers and scientists. Known as huitlacoche to Mexican chefs, the soot-like masses that form tumours within maize cobs are prized for their rich, smokey flavour and have been served in a variety of traditional dishes since the time of the Aztecs. Commonly known as corn smut to…
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UBC’s School of Biomedical Engineering (SBME) and Amgen are pleased to announce the inaugural 2022 Amgen Golden Ticket at SBME Innovates, providing a launchpad for two promising UBC spin-off ventures, Arrowsmith Genetics (AGx) and SeraGene. SBME is the first Canadian organization to host the Amgen Golden Ticket program. As the sponsor, Amgen provides mentorship to two teams selected by UBC for the period…
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