Publications of the Week RNA Modifications in Hematological Malignancies Jin, Z., et al. | March 23, 2023 RNA modifications play an important role in various cancers including blood cancers by controlling gene…pthomsonMarch 23, 2023 Read More
Publications of the Week Deconvolution of Clinical Variance in CAR-T Cell Pharmacology and Response Kirouac, D., et al. | March 20, 2023 Read the Publication This week we profile a recent publication in Nature Biotechnology from Dr.…pthomsonMarch 20, 2023 Read More
Publications of the Week Targeting Regulatory T Cell Metabolism in Disease: Novel Therapeutic Opportunities Halvorson, T., et al. | March 17, 2023 Regulatory T cells (Tregs) are essential for immune homeostasis and suppression of pathological autoimmunity but…pthomsonMarch 17, 2023 Read More
Publications of the Week Activation of β-Catenin in Mesenchymal Progenitors Leads to Muscle Mass Loss Kajabadi, M., et al. | March 15, 2023 Loss of muscle mass is a common manifestation of chronic disease. We find the canonical…pthomsonMarch 15, 2023 Read More
Publications of the Week Control of Focal Adhesion Kinase Activation by RUNX1-Regulated miRNAs in High-Risk AML Akhade, V. S., et al. | March 9, 2023 The major focus of Dr. Aly Karsan's lab is to understand the mechanisms of refractoriness…pthomsonMarch 9, 2023 Read More
Publications of the Week Circulating Tumor DNA: Toward Evolving the Clinical Paradigm of Pancreatic Ductal Adenocarcinoma Topham, J. T., et al. | March 8, 2023 Over a decade of sequencing-based genomics research has unveiled a diverse somatic mutation landscape across…pthomsonMarch 8, 2023 Read More
Publications of the Week In Silico Discovery of Small Molecules for Efficient Stem Cell Differentiation into Definitive Endoderm Novakovsky, G., et al. | March 3, 2023 Over 400 million people worldwide live with diabetes, a chronic disease caused by insulin deficiency…pthomsonMarch 3, 2023 Read More
Publications of the Week Clinical Application of Immune Repertoire Sequencing in Solid Organ Transplant Wong, P., et al. | March 2, 2023 Measurement of T cell receptor (TCR) or B cell receptor (BCR) gene utilization may be…pthomsonMarch 2, 2023 Read More
Publications of the Week A Luciferase Reporter Mouse Model to Optimize In Vivo Gene Editing Validated by Lipid Nanoparticledelivery of Adenine Base Editors Yu, S.-Y., et al. | February 23, 2023 The rapid development of CRISPR genome editing technology has provided the potential to treat genetic…pthomsonFebruary 23, 2023 Read More
Publications of the Week Development and Validation of an Advanced Ex Vivo Brain Slice Invasion Assay to Model Glioblastoma Cell Invasion into the Complex Brain Microenvironment Decotret, L. R., et al. | February 22, 2023 Organotypic cultures of murine brain slices are well-established tools in neuroscience research, including electrophysiology studies,…pthomsonFebruary 22, 2023 Read More