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SUMMARY:UBC x Web Summit
DESCRIPTION:The University of British Columbia is a catalyst for innovation. On a local and global scale\, we are seeing the outcomes of UBC research generate positive social\, health\, environmental and economic benefits. \nAs thousands descend upon Vancouver for Web Summit\, we are excited to host events showcasing the cutting-edge research and impact coming from academia\, introduce the next generation of research-based ventures and hear from our network of collaborators who are enabling change.
URL:https://scienceinvancouver.com/event/ubc-x-web-summit/
LOCATION:UBC Robson Square\, 800 Robson St\, Vancouver
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SUMMARY:Dr. Pinar Ayata: Neurodegenerative Functions of Microglia in Alzheimer’s Disease
DESCRIPTION:The brain’s primary immune cells\, microglia\, are a leading causal cell type in Alzheimer’s disease (AD). Yet\, the mechanisms by which microglia can drive neurodegeneration remain unresolved. Here\, we discover that a conserved stress signaling pathway\, the integrated stress response (ISR)\, characterizes a microglia subset with neurodegenerative outcomes. Autonomous activation of ISR in microglia is sufficient to induce early features of the ultrastructurally distinct “dark microglia” linked to pathological synapse loss. In AD models\, microglial ISR activation exacerbates neurodegenerative pathologies and synapse loss while its inhibition ameliorates them. Mechanistically\, we present evidence that ISR activation promotes the secretion of toxic lipids by microglia\, impairing neuron homeostasis and survival in vitro. Accordingly\, pharmacological inhibition of ISR or lipid synthesis mitigates synapse loss in AD models. Our results demonstrate that microglial ISR activation represents a neurodegenerative phenotype\, which may be sustained\, at least in part\, by the secretion of toxic lipids. \n 
URL:https://scienceinvancouver.com/event/dr-pinar-ayata-neurodegenerative-functions-of-microglia-in-alzheimers-disease/
LOCATION:Djavad Mowafaghian Centre for Brain Health\, 2215 Wesbrook Mall\, Vancouver\, British Columbia\, V6T 2B5\, Canada
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