We studied the whole-genome point mutation and structural variation patterns of 133 tumors (59 high-grade serous (HGSC), 35 clear cell (CCOC), 29 endometrioid (ENOC), and 10 adult granulosa cell (GCT)) as a substrate for class discovery in ovarian cancer. Ab initio clustering of integrated point mutation and structural variation signatures identified seven subgroups both between and within histotypes. Prevalence of…
Leading HIV/AIDS researcher Julio Montaner is among a group of scientists, writers, doctors and researchers receiving a prestigious prize for brilliant work in fields including health sciences, engineering and humanities. The Argentine-Canadian is among five scholars awarded this year’s Killam Prize, which honours Canadian researchers and scientists whose lifetime of work has impacted Canadians and citizens around the world. Each…
Dr. Julio Montaner, Director of the BC Centre for Excellence in HIV/AIDS, is one of five winners of the $100 000 Killam Prize. Grants Winner Grant Link to Article Dr. Shannon Kolind MS Society of Canada Grant Read More Awards Winner Award Link to Article Dr. Julio Montaner Killam Prize Read More Dr. Kalina Christoff Wall Scholars Research Award Read…
Heparin is a natural anticoagulant that derives its name from the tissue it was first isolated from: hepar in Greek means liver. Listed in the WHO Model List of Essential Medicines, heparin has stood the test of time as one of the oldest drugs still employed in clinical treatment to reduce clotting. However, heparin use is not without consequence as…
During pancreatic development, proliferating pancreatic progenitors activate the proendocrine transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differentiate into islet cells. The mechanisms that direct robust NEUROG3 expression within a subset of progenitor cells control the size of the endocrine population. Here we demonstrate that NEUROG3 is phosphorylated within the nucleus on serine 183, which catalyzes its hyperphosphorylation…
The federal science minister says universities aren’t doing the heavy lifting to appoint more female research chairs, so she wants to force their hands. On her way to give a speech Wednesday to university presidents in Montreal, Kirsty Duncan was handed the latest statistics on the number of men and women among applicants for new Canada Research Chair positions. “They’re…
Human papillomavirus (HPV) vaccines were originally approved with 3-dose schedules. However, 2 doses of HPV vaccine have been recommended1 for girls younger than 15 years based on antibody response at 36 months,2,3although continued research on the duration of antibody persistence was advised. We report antibody response at 60 months after 2 doses of quadrivalent HPV vaccine. Read More
Scientists at the Wellcome Trust Sanger Institute and their collaborators at the University of British Columbia have created an innovative technique for studying how chlamydia interacts with the human immune system. Researchers used a combination of gene editing and stem cell technologies to make the model. The team identified two genes from our immune system, IRF5 and IL-10RA as key…
It was something like a flashback for Canadian scientists who gathered across the country Saturday to rally in support of their American counterparts, who say they’re facing mounting attacks against science. Science advocate Katie Gibbs said she felt like she was returning a favour. Nearly five years ago, she was in the same place, doing almost the same thing. In…
Working with a shared voice can be very effective for improving outcomes in the Movement Disorders clinic, finds Dr. Martin McKeown and Parkinson’s research coordinator Kristen Sundvick. For some people with Parkinson’s disease (PD), even optimal drug treatments simply aren’t as effective as they need to be. On conventional medication, people may fluctuate unpredictably between being unable to move, to…
