Therapeutic molecules derived from antibodies have become a dominant class of drugs used to treat human disease. Increasingly, therapeutic antibodies are discovered using transgenic animal systems that have been engineered to express human antibodies. While the engineering details differ, these platforms share the ability to raise an immune response that is comprised of antibodies with fully human idiotypes. Although the…
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Bodo saltans virus, the first isolated representative of the most abundant giant viruses in the sea, has been unveiled by researchers at the University of British Columbia. The virus, whose genome weighs in at 1.39 million bases of DNA, is one of the largest giant viruses ever isolated, and the largest known to infect zooplankton. “Bodo saltans virus is one…
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Enteroviruses are responsible for an estimated 1 billion global infections per year. For most adults, these infections are asymptomatic, however for infants, young children, and those with compromised immunity, enteroviruses pose a significant health threat, leading to heart failure-induced sudden death and infections of the central nervous system. Currently, there are no effective treatments against these medically important viruses...
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Dr. Brian Kwon Wins ASIA Apple Award

Brian K. Kwon, MD, Professor in the Department of Orthopaedics at the University of British Columbia, the Canada Research Chair in Spinal Cord Injury, and the Dvorak Chair in Spine Trauma, is the recipient of ASIA’s 2018 Apple Award. His paper titled “Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury” appeared in the American Academy of…
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Dr. Evan Wood a Professor of Medicine at UBC and Director of the BC Centre on Substance Use was awarded a CIHR Operating Grant in the Opioid Crisis Knowledge Synthesis competition. Find out which other Vancouver researchers won grants, awards, fellowships, or scholarships this March!
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Undecaprenyl pyrophosphate phosphatase (UppP) is an integral membrane protein that recycles the lipid carrier essential to the ongoing biosynthesis of the bacterial cell wall. While deletion of the uppP gene is not lethal in vitro, its absence in vivo results in a significant decrease in virulence in mouse models of infection, making it a promising target for the development of novel antibacterial therapies. Our high-resolution crystal structure revealed the mechanistic basis for UppP’s intramembranal phosphatase activity and substrate specificity...
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Three internationally recognized researchers will join the University of British Columbia this year, bringing international talent in the fields of evolutionary genomics, functional genetics and social psychology as Canada 150 Research Chairs. Judith Mank, Josef Penninger and Azim Shariff are the latest international researchers to join UBC through the Canada 150 Research Chairs Program. The program was established by the…
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CHÉOS Scientists Successful in CIHR Funding Competitions

CHÉOS Scientists were successful in several CIHR funding competitions, announced in March. Drs. Skye Barbic and Steve Mathias will lead a team of researchers that will study how youth engagement can help investigators better measure and understand youth mental health in Canada. The funding for this study is through the Patient-Oriented Collaboration Grant program. Two groups of CHÉOS Scientists received funding through the SPOR Innovative…
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