Oxidative stress occurs when excess reactive oxygen species (ROS), ubiquitous byproducts of aerobic respiration, are produced in cells at levels that overwhelm the normal antioxidant capacity. Oxidative stress causes damage to proteins, lipids, and DNA, which contributes to many pathological conditions including diabetes, neurodegenerative diseases, and cancer, as well as aging. Hence, ROS levels need to be...
Read More
Translational research is a high-risk, iterative phase of the drug development pipeline that is critical in ensuring both a drug’s safety and efficacy. Key questions are answered about a potential drug in translational research: How quickly is it absorbed? How is it distributed to different tissues? How is it metabolized and excreted? At what dose is the drug toxic –…
Read More
Empirical observations over the past many decades have suggested that certain types of virus infections could lead to cancer regression. However, the use of so-called oncolytic viruses (OV) with the intent to treat cancer had been met with skepticism.  Now, thanks to technological advancements in genetic engineering and virus manufacturing, oncolytic virotherapy has gained considerable attention and demonstrated significant, though…
Read More
A new Vancouver-based study says taking ibuprofen every day can help prevent the onset of Alzheimer’s disease.  If started early enough, Canadian neuroscientists say using the over-the-counter medication can diminish the chances of developing the disease that currently affects an estimated 564,000 Canadians. Since 2016, president and CEO of Vancouver-based Aurin Biotech, Dr. Patrick McGeer and his team have been following…
Read More

New Antiretroviral Compound Derived From Sea Sponges

Simon Fraser University researchers have identified a chemical compound derived from sea sponges that inhibits HIV at low concentrations and has a mechanism of action that is distinct from licensed antiretroviral drugs. In a new study published in Antiviral Research, SFU Faculty of Heath Sciences researchers Ian Tietjen, Zabrina Brumme, and Mark Brockman and colleagues tested the antiviral properties of 252…
Read More
Droplet digital PCR (ddPCR) is an emerging technology for quantifying DNA. By partitioning the target DNA into ∼20000 droplets, each serving as its own PCR reaction compartment, a very high sensitivity of DNA quantification can be achieved. However, manual analysis of the data is time consuming and algorithms for automated analysis of non-orthogonal, multiplexed ddPCR data are unavailable, presenting a…
Read More
Public health surveillance programs and outbreak investigations have been dramatically enhanced through the use of whole genome sequencing (WGS). This is evidenced through the application of WGS in the understanding of tuberculosis (TB) transmission pathways, providing critical information to aid in controlling outbreaks and better identifying, testing, and treating those at risk in British Columbia as well as globally. However,…
Read More

Heather Yong: Plotting a Path From Bench to Bedside

Heather Yong is a Directed Studies student in the Faculty of Medicine at the University of British Columbia. She has been volunteering with the UBC MS/NMO Clinic and Research Group at the Djavad Mowafaghian Centre for Brain Health since 2013. In her final year of her undergraduate studies, Yong is already volunteering in the multiple sclerosis (MS) clinic, conducting epidemiological…
Read More
Researchers at the University of British Columbia have shed new light on how mountain pine beetles produce an important pheromone called trans-verbenol, which could aid in efforts to better predict outbreaks. In recent years, mountain pine beetles have destroyed more than 25 million hectares of pine forests in western North America. In a study published today in Proceedings of the National Academy…
Read More
Lara Boyd, Associate Professor, Department of Physical Therapy and Jennifer Gardy, Associate Professor, School of Population and Public Health are among twelve members of UBC who have been named B.C.’s most influential women of 2018: Stem Stars by BC Business. This honour is bestowed upon women who have made vital contributions to science, technology, engineering and math in B.C. Dr. Boyd is also…
Read More
"CRISPR-Cas