A recent study by a prolific TFRI-funded team has demonstrated that disrupting ERG transcriptional activity is sufficient to suppress the major characteristics of ERG-transformed prostate cancers. The finding could help develop new therapeutic tools for men battling ERG-expressing metastatic castration-resistant prostate cancer. There are currently few agents targeting cancer metastasis, and the need to create new therapeutics for these patients…
Effective September 1, Dr. Julie Robillard (pictured, right) has been appointed Associate Director of the National Core for Neuroethics. The National Core for Neuroethics is an interdisciplinary research group with a mission to protect and ensure public good by aligning innovations in the brain sciences with human values. Dr. Robillard’s research focus is on the experience of health care innovation in dementia…
The Terry Fox Research Institute has invested nearly $21.5-million to renew three 2017 Terry Fox New Frontiers Program Project Grants (PPGs). The projects, based at three leading cancer institutes across Canada, will investigate acute leukemia, oncolytic viruses, and nanoparticle imaging in cancer interventions respectively over the next five years. The successful teams are: The Terry Fox New Frontiers Program Project Grant…
BIOASIS TECHNOLOGIES INC., a biopharmaceutical company focused on overcoming the limitations of therapeutic drug delivery across the blood-brain barrier (BBB) and into the central nervous system for the treatment of neurological diseases and disorders, today announced the appointments of Prof. John H. Krystal, M.D., Jeffrey L. Cummings, M.D. and John P. Wikswo, Jr., Ph.D. to its newly established Scientific Advisory Board…
Plant defenses often involve specialized cells and tissues. In conifers, specialized cells of the bark are important for defense against insects and pathogens. Using laser microdissection, we characterized the transcriptomes of cortical resin duct cells, phenolic cells, and phloem of white spruce (Picea glauca) bark under constitutive and methyl jasmonate (MeJa)-induced conditions, and we compared these transcriptomes with the transcriptome…
In emergency medicine, there is a constant need for simple, robust methods to control traumatic hemorrhage. This form of trauma is made especially challenging when hemorrhages occur in remote locations lacking well-equipped medical facilities. With almost half of mortalities related to hemorrhage occurring within the first 24 hours, low-tech strategies to quickly control hemorrhages are crucial in these circumstances. To…
When Canada’s scientists and engineers have the opportunity to succeed, they’re able to make the discoveries that lead to ground-breaking innovations, sustainable economic growth and a stronger middle class. The hard work of these researchers also helps new generations of students master the advanced skills they need for the jobs of tomorrow. That is why the Minister of Science, Kirsty…
The manuscript describes our results of evaluating activity of darolutamide in enzalutamide-resistant CRPC as well as in androgen receptor (AR) mutants detected in patients after treatment with enzalutamide, abiraterone, or bicalutamide. We found that darolutamide potently inhibits enzalutamide-resistant CRPC both in vitro and in vivo. Moreover, darolutamide supppressed the transcriptional activity of AR mutants identified in the plasma of CRPC patients progressing on traditional therapies...
Genome BC has invested approximately $850,000 towards two projects that successfully illustrate the application of precision health in our Province’s public healthcare system. These evidence-based projects demonstrate the impact of genomics on healthcare challenges through increased efficiencies and new treatment options. The first project uses genomics to better prevent the spread of “superbugs” in hospitals and care facilities. Carbapenemase-producing organisms…
Dr. Liisa Galea began her tenure as Director of the Graduate Program in Neuroscience on July 1, taking over from Dr. Tim O’Connor who served the UBC neuroscience community in the role since 2011. “I know I have some big shoes to fill,” says Dr. Galea. A neuroscientist and professor in the Department of Psychology at UBC, Dr. Galea specializes in how sex…
