They are visionaries, innovators and trailblazers. They embody the values of modern leadership: engagement, trust, corporate citizenship, inclusion and innovation. Some of them are household names; some of them are well known within their industries. All of them influence life and business in British Columbia. BC500 features business leaders who have a notable impact on B.C.’s communities, industries and economy.…
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Loaded full of vitamins and minerals, rich in antioxidants, and bursting with flavour, blueberries are an icon of summertime in British Columbia. Families flock to farm gates and U-picks to bring home baskets of blueberry bounty destined for pies, jams, salads and taste buds. Like all food producers, BC’s blueberry farmers routinely deal with various pests and pathogens that damage…
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When NASA’s Artemis 1 lunar mission takes off on August 29, on board will be four science experiments—including one from Canada. UBC pharmaceutical sciences professor Dr. Corey Nislow is sending yeast and algae cultures into space, in a pod not much bigger than a shoebox, to study the effects of cosmic rays and near zero gravity on living organisms. When the spacecraft returns after…
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Human pluripotent stem cells (hPSCs) harbour enormous potential for regenerative medicine and offer a unique opportunity to advance the development of cell-based therapies. The development of hPSC biobanks, and use of hPSCs in clinical trials, drug screening, and disease modeling, all demand robust stem cell manufacturing and expansion. Although the hPSC manufacturing field is evolving rapidly, a bottleneck is throttling…
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Mentorship is an integral part of the CBR and the CBR Summer Studentship Program. Each year, the CBR will recognize an individual who has demonstrated outstanding commitment to mentorship and the development of others, in memory of Dr. Neil Mackenzie, a late Postdoctoral Fellow in Dr. Brömme’s lab. CBR members have the opportunity to nominate their mentors for the Neil Mackenzie Mentorship…
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Researchers at the University of British Columbia have discovered a key vulnerability across all major variants of the SARS-CoV-2 virus, including the recently emerged BA.1 and BA.2 Omicron subvariants. The weakness can be targeted by neutralizing antibodies, potentially paving the way for treatments that would be universally effective across variants. The findings, published today in Nature Communications, use cryo-electron microscopy (cryo-EM)…
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The transcription factor SOX9 is activated at the onset of endothelial-to-mesenchymal transition (EndMT) during embryonic development and in pathological conditions. Its roles in regulating these processes, however, are not clear. Using human umbilical vein endothelial cells (HUVECs) as an EndMT model, we show that SOX9 expression alone is sufficient to activate mesenchymal genes and steer endothelial cells towards a mesenchymal…
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Many people think of cells as the fundamental building blocks of life. These microscopic units are the foundation of every tissue and organ in our bodies. But inside each of these units is an incredible wealth of molecular machinery, and that presents opportunities for health and medicine. “We like to think of cells as fundamentally programmable units of life, so…
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Personalis, Inc. has announced a collaboration with BC Cancer to deploy a personalized liquid biopsy-based research use only (RUO) assay for a study of patients with colorectal and pancreatic cancers. The research efforts will deploy Personalis’ NeXT Personal, which has demonstrated high sensitivity for detecting circulating tumor DNA (ctDNA) from a patient’s blood sample, to determine the best time to…
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