The Best of the AACR Journals collection 2016 highlights the most-cited articles published in 2015 across the AACR journals. Three VPC scientists, Drs Chi, Collins & Gleave, are included in this prestigious group for their articles “Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer” in Clinical Cancer Research (Chi and Collins) and “Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of Castrate-Resistant Prostate Cancer” in Molecular Cancer Therapeutics (Gleave).