How is the human genome sequence packaged in addition to the double helical structure?
And how can we visualize, and learn about these alternate structures in the nucleus of the cell?
At the University of British Columbia Faculty of Pharmaceutical Sciences, Dr. Judy Wong and her team are investigating the formation of one alternate structure, the G-quadruplex (G4). This rare DNA structure is implicated in an increasing range of biological roles, with links to the pathology of ALS and frontotemporal dementia.
