Dr Peter Black has been awarded an MSFHR Health Professional-Investigator award in partnership with Vancouver Coastal Health Research Institute and VGH & UBC Hospital Foundation. The project, “Unraveling disparate roles of Notch-1 and Notch-2 signaling in bladder cancer” will further his ongoing work on the Notch signaling pathway in bladder cancer. Loss of the cell surface receptor Notch-1 drives growth of some bladder cancers, while increased Notch-2 activity drives other bladder cancers. Dr. Black’s proposed research will determine how Notch-1 and Notch-2 can lead to such differing effects on cancer growth even though they share many features in common, and will also enable the design of a new drug to inhibit Notch-2 specifically.
