On October 13, 1993, British Columbia’s Dr. Michael Smith received the Nobel Prize for his work on site-directed mutagenesis, a technique which for the first time allowed researchers to alter specific parts of the DNA code and understand how genes work, or why they don’t work. In 2018, 25 years after Smith won his Nobel Prize, organizations from across BC’s scientific research community are celebrating the powerful legacy of the province’s first Nobel Laureate. Smith’s impact and foundational work in genomics inspired many and helped propel our province to international prominence as a world leader in life sciences research.