Dr. Pauline Johnson has been featured in a month-long campaign by the Canadian Society for Immunology for her significant contributions to advancing knowledge of the structure, function and regulation of CD45.
A type I transmembrane protein present in various isoforms on all differentiated hematopoietic cells except erythrocytes and plasma cells, CD45 is an essential regulator of T- and B-cell antigen receptor signaling. Dr. Johnson’s work on CD44, a cell surface adhesion receptor highly expressed in many cancers is even more significant, according to Dr. Paul Ruffel, a researcher at the H. Lee Moffitt Cancer Center & Research Institute.
Dr. Johnson, a professor in UBC’s Department of Microbiology and Immunology, was nominated for inclusion in the campaign by the CSI’s trainee engagement committee.
