Publications of the Week Amyloidogenic Regions in Beta-Strands II and III Modulate the Aggregation and Toxicity of SOD1 in Living Cells McAlary, L., et al. | June 6, 2024 Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial…karnottJune 6, 2024 Read More
Publications of the Week siRNA-Mediated Reduction of a Circulating Protein in Swine Using Lipid Nanoparticles Cau, M., et al. | May 30, 2024 Genetic manipulation of animal models is a fundamental research tool in biology and medicine but…karnottMay 30, 2024 Read More
Publications of the Week Gelsolin Regulates Receptor-Mediated and Fluid-Phase Endocytosis in Platelets Paul, M., et al. | May 29, 2024 Endocytosis is the process by which platelets incorporate extracellular molecules into their secretory granules. Endocytosis…karnottMay 29, 2024 Read More
Publications of the Week N-MYC Impairs Innate Immune Signaling in High-Grade Serous Ovarian Carcinoma Miranda, A., et al. | May 23, 2024 High-grade serous ovarian cancer (HGSC) is a challenging disease, especially for patients with immunologically “cold”…karnottMay 23, 2024 Read More
Publications of the Week DNA-PK Inhibitor AZD7648 Is a More Portent Radiosensitizer than PARP Inhibitor Olaparib in BRCA1/2 Deficient Tumors Wang, T., et al. | May 22, 2024 The effectiveness of radiotherapy depends on the sensitivities of ‘normal’ and cancer cells to the…karnottMay 22, 2024 Read More
Publications of the Week Kinetic Comparison of All Eleven Viral Polyprotein Cleavage Site Processing Events by SARS-CoV-2 Main Protease Using a Linked Protein FRET Platform Kenward, C., et al. | May 17, 2024 The main protease (Mpro) remains an essential therapeutic target for COVID-19 post infection intervention given…karnottMay 17, 2024 Read More
Publications of the Week Conclusive Demonstration of Iatrogenic Alzheimer’s Disease Transmission in a Model of Stem Cell Transplantation Singh, C., et al. | May 13, 2024 The risk of iatrogenic disease is often underestimated as a concern in contemporary medical procedures,…karnottMay 13, 2024 Read More
Publications of the Week A Novel Type-2 Innate Lymphoid Cell-Based Immunotherapy for Cancer Saranchova, I., et al. | May 7, 2024 Cell-based cancer immunotherapy has achieved significant advancements, providing a source of hope for cancer patients.…karnottMay 7, 2024 Read More
Publications of the Week Cdk8/CDK19 Promotes Mitochondrial Fission Through Drp1 Phosphorylation and Can Phenotypically Suppress pink1 Deficiency in Drosophila Liao, J., et al. | May 2, 2024 Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have been…karnottMay 2, 2024 Read More
Publications of the Week An Esophagus Cell Atlas Reveals Dynamic Rewiring During Active Eosinophilic Esophagitis and Remission Ding, J., et al. | April 26, 2024 Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis…karnottApril 26, 2024 Read More