Publications of the Week LAG-3+ Tumor Infiltrating Lymphocytes in Breast Cancer: Clinical Correlates and Association with PD-1/PD-L1+ TumorsBurugu, S. and Nielsen, T.O., et al. | November 8, 2017Novel immune checkpoint blockade strategies are being evaluated in clinical trials and include targeting the…sciencecityNovember 8, 2017 Read More
Publications of the Week Investigating Immune Gene Signatures in Peripheral Blood from Subjects with Allergic Rhinitis Undergoing Nasal Allergen ChallengeKim, Y.W. and Tebbutt, S.J., et al. | November 6, 2017We discovered systemic immune response signatures that were highly correlated to upper airway clinical symptom…sciencecityNovember 6, 2017 Read More
Publications of the Week Participant Selection for Lung Cancer Screening by Risk Modelling: a Single-Arm, Prospective StudyTammemagi, M.C. and Lam, S., et al. | November 2, 2017Results from retrospective studies indicate that selecting individuals for low-dose CT lung cancer screening on the basis of a highly…sciencecityNovember 2, 2017 Read More
Publications of the Week Engineered In-Vitro Cell Line Mixtures and Robust Evaluation of Computational Methods for Clonal Decomposition and Longitudinal Dynamics in CancerFarahani, H. and Shah, S., et al. | November 1, 2017Characterization and quantification of tumour clonal populations over time via longitudinal sampling are essential components…sciencecityNovember 1, 2017 Read More
Publications of the Week RECQ-Like Helicases Sgs1 and BLM Regulate R-Loop-Associated Genome InstabilityChang, E.Y. and Stirling, P.C., et al. | October 30, 2017Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning…sciencecityOctober 30, 2017 Read More
Publications of the Week Antimicrobial Resistance Gene Acquisition and Depletion Following Fecal Microbiota Transplantation (FMT) for Recurrent Clostridium Difficile InfectionLeung, V. and Manges, A.R., et al. | October 26, 2017Fecal microbiota transplantation (FMT) may be a novel approach to eliminate multidrug-resistant bacteria from the…sciencecityOctober 26, 2017 Read More
Publications of the Week REVIEW: Emerging Targets in Cancer ImmunotherapyBurugu, S. and Nielsen, T.O., et al. | October 25, 2017The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1) targeted natural immune homeostasis pathways,…sciencecityOctober 25, 2017 Read More
Publications of the Week Multi-Target-Directed Phenol-Triazole Ligands as Therapeutic Agents for Alzheimer’s DiseaseJones, M.R. and Storr, T., et al. | October 23, 2017This work was spearheaded by a former graduate student Michael Jones (5th from left) who…sciencecityOctober 23, 2017 Read More
Publications of the Week Self-Biotinylation of DNA G-Quadruplexes via Intrinsic Peroxidase ActivityEinarson, O.J. and Sen, D. | October 20, 2017The striking and ubiquitous in vitro affinity between hemin and DNA/RNA G-quadruplexes raises the intriguing…sciencecityOctober 20, 2017 Read More
Publications of the Week Selective Aggregation of the Splicing Factor Hsh155 Suppresses Splicing upon Genotoxic StressMathew, V. and Stirling, P.C., et al. | October 18, 2017When a cell responds to DNA damage it must coordinate DNA repair with changes in…sciencecityOctober 18, 2017 Read More