Publications of the Week cGAS-STING and Cancer: Dichotomous Roles in Tumor Immunity and DevelopmentNg, K.W. and Lam, W.L., et al. | September 5, 2017cGMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) sensing has emerged as a key regulator of…sciencecitySeptember 5, 2017 Read More
Publications of the Week Hsp83 Loss Suppresses Proteasomal Activity Resulting in an Upregulation of Caspase-Dependent Compensatory AutophagyChoutka, C. and Gorski, S.M., et al. | September 1, 2017We utilized the fruitfly model organism, Drosophila melanogaster, to discover novel relationships between two proteins…sciencecitySeptember 1, 2017 Read More
Publications of the Week Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal MelanomaRobertson, A.G., et al. | August 30, 2017UVM arises from melanocytes (melanin pigment producing cells) that reside in the uveal tract of…sciencecityAugust 30, 2017 Read More
Publications of the Week REVIEW: Regenerative Medicine and Cell-Based Approaches to Restore Pancreatic FunctionEllis, C. and Kieffer, T.J., et al. | August 29, 2017The pancreas is a complex organ with exocrine and endocrine components. Many pathologies impair exocrine…sciencecityAugust 29, 2017 Read More
Publications of the Week TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule DynamicsMackenzie, I.R., et al. | August 28, 2017The general focus of our UBC Frontotemporal Dementia (FTD) research group is to improve diagnosis…sciencecityAugust 28, 2017 Read More
Publications of the Week Bypassing Drug-Resistance Mechanisms of Prostate Cancer with Small-Molecules That Target Androgen Receptor Chromatin InteractionsDalal, K. and Rennie, P.S., et al. | August 25, 2017We tested our lead anti-AR DBD inhibitor, VPC-14449, on a panel of anti-androgen resistant prostate…sciencecityAugust 25, 2017 Read More
Publications of the Week De Novo Mutations in YWHAG Cause Early-Onset EpilepsyGuella, I. and Farrer, M.J., et al. | August 23, 2017These gene mutations are the latest discovered in epilepsy, and enable a much faster more…sciencecityAugust 23, 2017 Read More
Publications of the Week Near-Atomic Resolution Cryoelectron Microscopy Structure of the 30-Fold Homooligomeric SpoIIIAG Channel Essential to Spore Formation in Bacillus SubtilisZeytuni, N. and Strynadka, N.C., et al. | August 21, 2017Bacterial sporulation allows starving cells to differentiate into metabolically dormant spores that can survive extreme…sciencecityAugust 21, 2017 Read More
Publications of the Week Amyloid Formation Disrupts the Balance between Interleukin-1β and Interleukin-1 Receptor Antagonist in Human IsletsHui, Q. and Marzban, L., et al. | August 18, 2017β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis…sciencecityAugust 18, 2017 Read More
Publications of the Week Systemic Inflammation Combined with Neonatal Cerebellar Hemorrhage Aggravates Long-Term Structural and Functional Outcomes in a Mouse ModelTremblay, S. and Goldowitz, D., et al. | August 17, 2017Infants born preterm are highly susceptible to various environmental stressors during their first few weeks…sciencecityAugust 17, 2017 Read More