Publications of the Week The Interactome of Metabolic Enzyme Carbonic Anhydrase IX Reveals Novel Roles in Tumor Cell Migration and Invadopodia/MMP14-Mediated InvasionSwayampakula, M. and Dedhar, S., et al | July 26, 2017Carbonic anhydrase IX (CAIX) is a hypoxia inducible factor 1-induced, cell surface pH regulating enzyme…sciencecityJuly 26, 2017 Read More
Publications of the Week REVIEW: Genes and Molecular Pathways Underpinning CiliopathiesLeroux, M.R., et al. | July 25, 2017Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The dysfunction of cilia causes…sciencecityJuly 25, 2017 Read More
Publications of the Week Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends LifespanTempleman, N.M. and Johnson, J.D., et al. | July 24, 2017Our well-powered study had two major findings, both of which have profound implications across multiple…sciencecityJuly 24, 2017 Read More
Publications of the Week Vitamin C-Induced Epigenomic Remodelling in IDH1 Mutant Acute Myeloid LeukaemiaMingay, M. and Hirst, M., et al. | July 21, 2017Mutations in genes encoding epigenetic regulators as well as mutations in the histones they modify…sciencecityJuly 21, 2017 Read More
Publications of the Week Loss-Of-Function and Gain-Of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic EncephalopathyLehman, A. and Claydon, T., et al. | July 19, 2017KCNQ5 is a highly conserved gene encoding an important channel for neuronal function; it is…sciencecityJuly 19, 2017 Read More
Publications of the Week Clear Cell and Endometrioid Carcinomas: Are Their Differences Attributable to Distinct Cells of Origin?Cochrane, D.R. and Huntsman, D.G., et al. | July 17, 2017Endometrial epithelium is the presumed tissue of origin for both eutopic and endometriosis-derived clear cell…sciencecityJuly 17, 2017 Read More
Publications of the Week Optogenetic Rewiring of Thalamocortical Circuits to Restore Function in the Stroke Injured BrainTennant, K.A. and Brown, C.E., et al. | July 14, 2017Read the Publication This week we profile a recent publication in Nature Communications from Dr.…sciencecityJuly 14, 2017 Read More
Publications of the Week Myelin Regulatory Factor Drives Remyelination in Multiple SclerosisDuncan, G.J. and Tetzlaff, W., et al. | July 12, 2017Remyelination is limited in the majority of multiple sclerosis (MS) lesions despite the presence of…sciencecityJuly 12, 2017 Read More
Publications of the Week REVIEW: Synthetic Lethality and CancerO'Neil, N.J. and Hieter, P., et al. | July 10, 2017A synthetic lethal interaction occurs between two genes when the perturbation of either gene alone…sciencecityJuly 10, 2017 Read More
Publications of the Week BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer’s PathogenesisZhang, S. and Song, W., et al. | July 6, 2017Mutations in amyloid β precursor protein (APP) gene alter APP processing, either causing familial Alzheimer's…sciencecityJuly 6, 2017 Read More