Publications of the Week Transcriptional Coactivator MED15 Is Required for Beta Cell MaturationKadhim, A., et al. | December 5, 2024Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors…karnottDecember 5, 2024 Read More
Publications of the Week The Glycosyltransferase ST3GAL4 Drives Immune Evasion in Acute Myeloid Leukemia by Synthesizing Ligands for the Glyco-Immune Checkpoint Receptor Siglec-9Krishnamoorthy, V., et al. | December 3, 2024Immunotherapy has demonstrated promise as a treatment for acute myeloid leukemia (AML). However, there is…karnottDecember 3, 2024 Read More
Publications of the Week Microbial Intestinal Dysbiosis Drives Long-Term Allergic Susceptibility by Sculpting an ILC2-B1 Cell-Innate IgE AxisKabil, A., et al. | November 28, 2024The abundance and diversity of intestinal commensal bacteria influence systemic immunity with impact on disease…karnottNovember 28, 2024 Read More
Publications of the Week Luminal Breast Epithelial Cells of BRCA1 or BRCA2 Mutation Carriers and Noncarriers Harbor Common Breast Cancer Copy Number AlterationsWilliams, M., et al. | November 27, 2024The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium and their…karnottNovember 27, 2024 Read More
Publications of the Week Antithrombotic Coating with Sheltered Positive Charges Prevents Contact Activation by Controlling Factor XII–Biointerface BindingJi, H., et al. | November 18, 2024Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices.…karnottNovember 18, 2024 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined NichesStankiewicz, L., et al. | November 15, 2024This week, we profile a recent publication in Developmental Cell by Dr. Fabio Rossi (pictured)…karnottNovember 15, 2024 Read More
Publications of the Week Predictive Gene Expression Signature Diagnoses Neonatal Sepsis Before Clinical PresentationAn, A., et al. | November 5, 2024Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There…karnottNovember 5, 2024 Read More
Publications of the Week A Community Effort to Optimize Sequence-Based Deep Learning Models of Gene RegulationMuntakim Rafi, A., et al. | October 30, 2024A systematic evaluation of how model architectures and training strategies impact genomics model performance is…karnottOctober 30, 2024 Read More
Publications of the Week Transient CAR T Cells with Specificity to Oncofetal Glycosaminoglycans in Solid TumorsKhazamipour, N., et al. | October 25, 2024Glycosaminoglycans are often deprioritized as targets for synthetic immunotherapy due to the complexity of glyco-epitopes…karnottOctober 25, 2024 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined NichesStankiewicz, L., et al. | October 14, 2024Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions…karnottOctober 14, 2024 Read More