Publications of the Week Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock Takahashi, N., et al. | October 27, 2025 To determine whether low-density lipoprotein cholesterol (LDL-C) levels, set by the balance of clearance and…karnottOctober 27, 2025 Read More
Publications of the Week Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles Across mRNA Modalities Casmil, I., et al. | October 23, 2025 This week, we profile a recent publication in Advanced Science by Dr. Anna Blakney’s lab…karnottOctober 23, 2025 Read More
Publications of the Week CAR Treg Cells Mediate Linked Suppression and Infectious Tolerance in Islet Transplantation in Mice Wardell, C., et al. | October 21, 2025 Islet transplantation represents an attractive therapeutic approach for type 1 diabetes; however, it can also…karnottOctober 21, 2025 Read More
Publications of the Week Randomized, Double-Blind, Placebo-Controlled Phase 2A Study Assessing the Efficacy and Safety of Felzartamab for IgA Nephropathy Floege, J., et al. | October 15, 2025 Felzartamab is a fully human anti-CD38 monoclonal antibody under investigation for treatment of IgA nephropathy…karnottOctober 15, 2025 Read More
Publications of the Week Positive Allosteric Modulation of M1 mAChRs with VU0486846 Reverses Cognitive Deficits in Male APPswe/PSEN1ΔE9 Alzheimer’s Mice Ibrahim, K., et al. | October 7, 2025 Alzheimer's disease (AD) is an age-associated neurodegenerative disease marked by progressive cognitive deterioration and beta-amyloid…karnottOctober 7, 2025 Read More
Publications of the Week Sex-Specific Metabolic and Central Effects of GLP-1–Estradiol Conjugate in Middle-Aged Rats on a Standard or Western Diet Richard, J., et al. | October 3, 2025 Middle age represents a critical window for metabolic and cognitive health, particularly in the context…karnottOctober 3, 2025 Read More
Publications of the WeekUncategorized Somatic IRF4 Mutations and Thymic Tropism in Primary Mediastinal Large B-Cell Lymphoma Rai, S., et al. | September 26, 2025 Disease-defining signatures in lymphomas, driven by intricate molecular mechanisms, have advanced molecular taxonomies, refined classification,…karnottSeptember 26, 2025 Read More
Publications of the Week Drug Tolerance and Persistence to EGFR Inhibitor Treatment Are Mediated by an ILK-SFK-YAP Signaling Axis in Lung Adenocarcinoma Shi, R., et al. | September 19, 2025 This week, we profile a recent publication in Oncogene by Dr. William Lockwood's lab (pictured). Since…karnottSeptember 19, 2025 Read More
Publications of the Week ERBB2/HER2 Alterations in ctDNA and Metachronous Tissues of Patients with Metastatic Urothelial Cancer Vandekerkhove, G., et al. | September 18, 2025 HER2 targeting is increasingly relevant in metastatic urothelial cancer (mUC) because of emerging antibody–drug conjugates,…karnottSeptember 18, 2025 Read More
Publications of the Week Revealing Function-Altering MECP2 Mutations in Individuals With Autism Spectrum Disorder Using Yeast and Drosophila Chen, E., et al. | September 17, 2025 Pathogenic variants in MECP2 commonly lead to Rett syndrome, where MECP2's function as a DNA…karnottSeptember 17, 2025 Read More