Publications of the Week Prospective Multicenter Study of ctDNA Versus Tumor Tissue Guiding FGFR-Targeted Therapy in Metastatic Urothelial Cancer Müller, D., et al. | March 25, 2026 Fibroblast growth factor receptor (FGFR) alterations are targetable in metastatic urothelial carcinoma (mUC). Identifying FGFR…karnottMarch 25, 2026 Read More
Publications of the Week A Long Noncoding RNA–Based Classifier for Identifying More Aggressive Low-Grade Ta Bladder Cancer with Elevated FGFR3 Activity Phung, T., et al. | March 20, 2026 Low-grade, stage Ta (TaLG) non–muscle-invasive bladder cancer (NMIBC) is generally nonaggressive; yet, some patients experience…karnottMarch 20, 2026 Read More
Publications of the Week Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody Responses Despins, C., et al. | March 12, 2026 Background: mRNA LNP technology is now being widely applied as a highly effective vaccine platform.…karnottMarch 12, 2026 Read More
Publications of the Week Formulation and Administration Timing of Lipid Derivatized JAK-Inhibitor and Corticosteroid Modulate saRNA-LNP Inflammation and Expression Bathula, N., et al. | March 6, 2026 Self-amplifying RNA (saRNA)-lipid nanoparticle (LNP) therapeutics represent a transformative advance in nucleic acid medicine, enabling…karnottMarch 6, 2026 Read More
Publications of the Week Silencing of Human HTT by Targeted CRISPR/dCas9-Mediated Epigenetic Editing Tay, Y., et al. | February 23, 2026 Gene silencing is widely recognized as a promising therapeutic approach for dominant monogenic disorders. Current…karnottFebruary 23, 2026 Read More
Publications of the Week Clonal Hematopoiesis After 177Lu-PSMA-617 Radioligand Therapy in Prostate Cancer Munzur, A., et al. | February 20, 2026 Background: Clonal hematopoiesis (CH) is a precursor state linked to risk of hematological neoplasms, and…karnottFebruary 20, 2026 Read More
Publications of the Week Direct Measurement of Free Glucocorticoids in Small Volumes of Mouse and Rat Serum Using Ultrafiltration and Liquid Chromatography-Tandem Mass Spectrometry Mazurenko, A., et al. | February 17, 2026 Glucocorticoids are critical steroid hormones secreted from the adrenal glands. In mice and rats, over…karnottFebruary 17, 2026 Read More
Publications of the Week Multidimensional Characterization of Tumour–Immune Architecture Reveals Clinically Relevant Classic Hodgkin Lymphoma Subtypes Aoki, T., et al. | February 12, 2026 The tissue architecture of classic Hodgkin Lymphoma (CHL) is unique among cancers and characterized by…karnottFebruary 12, 2026 Read More
Publications of the Week GluN2B-Specific NMDAR Positive Allosteric Modulation Reverses Cognitive and Behavioral Abnormalities in Mecp2 and Disc1 Transgenic Mice Ge., Y., et al. | February 10, 2026 The GluN2B subunit of N-methyl-d-aspartate receptors (NMDARs) plays a central role in synaptic development and…karnottFebruary 10, 2026 Read More
Publications of the Week A Bacteroides Synthetic Biology Toolkit To Build an in Vivo Malabsorption Biosensor McCallum, G., et al. | February 5, 2026 The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence…karnottFebruary 5, 2026 Read More