Publications of the Week Silencing of Human HTT by Targeted CRISPR/dCas9-Mediated Epigenetic Editing Tay, Y., et al. | February 23, 2026 Gene silencing is widely recognized as a promising therapeutic approach for dominant monogenic disorders. Current…karnottFebruary 23, 2026 Read More
Publications of the Week Clonal Hematopoiesis After 177Lu-PSMA-617 Radioligand Therapy in Prostate Cancer Munzur, A., et al. | February 20, 2026 Background: Clonal hematopoiesis (CH) is a precursor state linked to risk of hematological neoplasms, and…karnottFebruary 20, 2026 Read More
Publications of the Week Direct Measurement of Free Glucocorticoids in Small Volumes of Mouse and Rat Serum Using Ultrafiltration and Liquid Chromatography-Tandem Mass Spectrometry Mazurenko, A., et al. | February 17, 2026 Glucocorticoids are critical steroid hormones secreted from the adrenal glands. In mice and rats, over…karnottFebruary 17, 2026 Read More
Publications of the Week Multidimensional Characterization of Tumour–Immune Architecture Reveals Clinically Relevant Classic Hodgkin Lymphoma Subtypes Aoki, T., et al. | February 12, 2026 The tissue architecture of classic Hodgkin Lymphoma (CHL) is unique among cancers and characterized by…karnottFebruary 12, 2026 Read More
Publications of the Week GluN2B-Specific NMDAR Positive Allosteric Modulation Reverses Cognitive and Behavioral Abnormalities in Mecp2 and Disc1 Transgenic Mice Ge., Y., et al. | February 10, 2026 The GluN2B subunit of N-methyl-d-aspartate receptors (NMDARs) plays a central role in synaptic development and…karnottFebruary 10, 2026 Read More
Publications of the Week A Bacteroides Synthetic Biology Toolkit To Build an in Vivo Malabsorption Biosensor McCallum, G., et al. | February 5, 2026 The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence…karnottFebruary 5, 2026 Read More
Publications of the Week Lipid Nanoparticle-Based Non-Viral in Situ Gene Editing of Congenital Ichthyosis-Causing Mutations in Human Skin Models Apaydin, D., et al. | February 3, 2026 Autosomal recessive congenital ichthyosis (ARCI) refers to a group of rare, highly debilitating skin disorders…karnottFebruary 3, 2026 Read More
Publications of the Week Noncanonical Functions of UGT2B17 Promote Castration-Resistant Prostate Cancer Progression Feng, T., et al. | January 29, 2026 Androgen deprivation therapy is the primary treatment for advanced prostate tumors. While initially effective, tumor…karnottJanuary 29, 2026 Read More
Publications of the Week Distinct Biological Subtypes of Chronic GVHD After Pediatric Hematopoietic Cell Transplantation Ng, B., et al. | January 27, 2026 Chronic graft-versus-host-disease (cGVHD) is the primary nonrelapse limitation to a successful hematopoietic cell transplantation and…karnottJanuary 27, 2026 Read More
Publications of the Week A Binary Self-Amplifying Expression Platform Enabling Lipid Nanoparticle-Free Vaccines and Nanomedicines Jefferies, W., et al. | January 22, 2026 Conventional mRNA vaccines played a crucial role in mitigating the COVID-19 pandemic but remain hampered…karnottJanuary 22, 2026 Read More