Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined NichesStankiewicz, L., et al. | November 15, 2024This week, we profile a recent publication in Developmental Cell by Dr. Fabio Rossi (pictured)…karnottNovember 15, 2024 Read More
Publications of the Week Predictive Gene Expression Signature Diagnoses Neonatal Sepsis Before Clinical PresentationAn, A., et al. | November 5, 2024Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There…karnottNovember 5, 2024 Read More
Publications of the Week A Community Effort to Optimize Sequence-Based Deep Learning Models of Gene RegulationMuntakim Rafi, A., et al. | October 30, 2024A systematic evaluation of how model architectures and training strategies impact genomics model performance is…karnottOctober 30, 2024 Read More
Publications of the Week Transient CAR T Cells with Specificity to Oncofetal Glycosaminoglycans in Solid TumorsKhazamipour, N., et al. | October 25, 2024Glycosaminoglycans are often deprioritized as targets for synthetic immunotherapy due to the complexity of glyco-epitopes…karnottOctober 25, 2024 Read More
Publications of the Week Sex-Biased Human Thymic Architecture Guides T Cell Development Through Spatially Defined NichesStankiewicz, L., et al. | October 14, 2024Within the thymus, regulation of the cellular crosstalk directing T cell development depends on spatial interactions…karnottOctober 14, 2024 Read More
Publications of the Week Discovery of Benzo[c]phenanthridine Derivatives with Potent Activity Against Multidrug-Resistant Mycobacterium tuberculosisLiang, Y., et al. | October 11, 2024Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis (TB), is the leading cause of bacterial disease-related…karnottOctober 11, 2024 Read More
Publications of the Week Genetic Engineering of Megakaryocytes from Blood Progenitor Cells Using mRNA Lipid NanoparticlesLeung, J., et al. | October 4, 2024Platelets are an essential component of hemorrhage control and management, and engineering platelets to express…karnottOctober 4, 2024 Read More
Publications of the Week Immune Regulatory and Anti-Resorptive Activities of Tanshinone IIA Sulfonate Attenuates Rheumatoid Arthritis in MicePanwar, P., et al. | September 27, 2024Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and painful joint destruction.…karnottSeptember 27, 2024 Read More
Publications of the Week Protein Is Expressed in All Major Organs After Intravenous Infusion of mRNA-Lipid Nanoparticles in SwineFerraresso, F., et al. | September 19, 2024In vivo delivery of mRNA is promising for the study of gene expression and the treatment…karnottSeptember 19, 2024 Read More
Publications of the Week Single Cell Glucose-Stimulated Insulin Secretion Assay Using Nanowell-in-Microwell PlatesJang, D., et al. | September 13, 2024Pancreatic β cells secrete insulin in response to elevated levels of glucose. Stem cell derived…karnottSeptember 13, 2024 Read More