Publications of the Week Targeted Splicing Approach for Alleviation of a Neurexin 1 Haploinsufficiency Model Lu, H., et al. | September 11, 2025 NRXN1 encoding the synaptic organizing protein neurexin 1 (Nrxn1) is among the strongest risk genes…karnottSeptember 11, 2025 Read More
Publications of the Week Human Milk IgA Promotes Normal Immune Development by Limiting Th17-Inducing Erysipelatoclostridium ramosum in the Infant Gut Donald, K., et al. | September 4, 2025 The infant gut microbiota plays a vital role in immune development. Secretory IgA (SIgA), the…karnottSeptember 4, 2025 Read More
Publications of the Week Biodegradable Polymers with Tertiary Amines Enhance mRNA Delivery of Lipid Nanoparticles via Improved Endosomal Escape Zhao, F., et al. | August 29, 2025 Messenger RNA (mRNA)-based therapy has become a promising and scalable approach for treating various diseases,…karnottAugust 29, 2025 Read More
Publications of the Week SIRT1/DNMT3B-Mediated Epigenetic Gene Silencing in Response Tophytoestrogens in Mammary Epithelial Cells Ma, Y., et al. | August 28, 2025 We performed an integrated analysis of genome-wide DNA methylation and expression datasetsin normal cells and…karnottAugust 28, 2025 Read More
Publications of the Week Artificial Cellulose Derivatives Are Metabolized by Select Human Gut Bacteroidota upon Priming with Common Plant β-Glucans Panwar, D., et al. | August 20, 2025 Synthetic ethers of cellulose (β(1,4)-glucan) are widely used in the food and pharmaceutical industry as…karnottAugust 20, 2025 Read More
Publications of the Week The Parkinson’s Drug Benztropine Possesses Histamine Receptor 1-Dependent Host-Directed Antimicrobial Activity Against Mycobacterium tuberculosis Sahile, H., et al. | August 12, 2025 Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) evade host defence mechanisms to infect and survive…karnottAugust 12, 2025 Read More
Publications of the Week Defining Enteric Bacterial Pathogenesis Using Organoids: Citrobacter rodentium Uses EspC, an Atypical Mucinolytic Protease, to Penetrate Mouse Colonic Mucus Chen, Y., et al. | August 8, 2025 Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they…karnottAugust 8, 2025 Read More
Publications of the Week DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Thomas, N., et al. | August 1, 2025 The genetic subtypes of Burkitt lymphoma have been defined, but the role of epigenetics remains…karnottAugust 1, 2025 Read More
Publications of the Week CXCR4-LASP1-G9a-Snail Axis Drives NEPC Transdifferentiation via Induction of EMT and Downregulation of REST Liu, L., et al. | July 21, 2025 Phenotypic switching is an emerging driver of cancer treatment resistance, yet early signals regulating this…karnottJuly 21, 2025 Read More
Publications of the Week Drug Tolerance and Persistence to EGFR Inhibitor Treatment Are Mediated by an ILK-SFK-YAP Signaling Axis in Lung Adenocarcinoma Shi, R., et al. | July 16, 2025 Combating resistance to targeted therapy remains a major challenge to improving lung cancer care. Epithelial-mesenchymal…karnottJuly 16, 2025 Read More