Publications of the Week Premature Termination Codon Readthrough Upregulates Progranulin Expression and Improves Lysosomal Function in Preclinical Models of GRN Deficiency Molecular Neurodegeneration | March 27, 2020 Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of…sciencecityMarch 27, 2020 Read More
Publications of the Week A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance Morris, E.J., et al. | March 26, 2020 The authors describe a very interesting mechanism for the regulation of symmetric versus asymmetric cellular…sciencecityMarch 26, 2020 Read More
Publications of the Week Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins Hamza, A., et al. | March 20, 2020 Cross-species complementation can be used to generate humanized yeast, which is a valuable resource with…sciencecityMarch 20, 2020 Read More
Publications of the Week Identification of Alzheimer’s Disease–Associated Rare Coding Variants in the ECE2 Gene Liao, X., et al. | March 18, 2020 Accumulation of amyloid β protein (Aβ) due to increased generation and/or impaired degradation plays an…sciencecityMarch 18, 2020 Read More
Publications of the Week Coding and Non-Coding Drivers of Mantle Cell Lymphoma Identified through Exome and Genome Sequencing Pararajalingam, P., et al. | March 13, 2020 Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is incurable with…sciencecityMarch 13, 2020 Read More
Publications of the Week Distinct Features of Stress Granule Proteins Predict Localization in Membraneless Organelle Kuechler, E.R., et al. | March 12, 2020 Recently generated proteomic data provides unprecedented insight into stress granule composition and stands as fruitful…sciencecityMarch 12, 2020 Read More
Publications of the Week Identification of Gene Signature for Treatment Response to Guide Precision Oncology in Clear-Cell Renal Cell Carcinoma D’Costa, N.M., et al. | March 6, 2020 Clear-cell renal cell carcinoma (ccRCC) is a common therapy resistant disease with aberrant angiogenic and…sciencecityMarch 6, 2020 Read More
Publications of the Week TMEM30A Loss-of-Function Mutations Drive Lymphomagenesis and Confer Therapeutically Exploitable Vulnerability in B-Cell Lymphoma Ennishi, D., et al. | March 4, 2020 Transmembrane protein 30A (TMEM30A) maintains the asymmetric distribution of phosphatidylserine, an integral component of the…sciencecityMarch 4, 2020 Read More
Publications of the Week Spatio-Temporal Characterization of the Antiviral Activity of the XRN1-DCP1/2 Aggregation against Cytoplasmic RNA Viruses to Prevent Cell Death Ng, C.S., et al. | February 25, 2020 The authors have identified a new cellular antiviral mechanism involving the host RNA degradation system.…sciencecityFebruary 25, 2020 Read More
Publications of the Week Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors Luo, L., et al. | February 24, 2020 The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and…sciencecityFebruary 24, 2020 Read More