Publications of the Week Basal-like Breast Cancers: From Pathology to Biology and Back AgainGusterson, B. and Eaves, C.J. | June 18, 2018Human breast cancers referred to as "basal-like" are of interest because they lack effective therapies…sciencecityJune 18, 2018 Read More
Publications of the Week Single-Cell Analysis Identifies a CD33+ Subset of Human Cord Blood Cells with High Regenerative PotentialKnapp, D.J.H.F. and Eaves, C.J., et al. | June 15, 2018In this publication we create functional and molecular maps of the blood stem cell compartment…sciencecityJune 15, 2018 Read More
Publications of the Week Phase 1 Trials of Anti-enpp3 Antibody Drug Conjugates in Advanced Refractory Renal Cell CarcinomasThompson, J.A., and Kollmannsberger, C., et al. | June 13, 2018To determine the safety, pharmacokinetics, and recommendedphase2 dose of an antibody drug conjugate (ADC) targeting…sciencecityJune 13, 2018 Read More
Publications of the Week A Molecular Network of the Aging Human Brain Provides Insights into the Pathology and Cognitive Decline of Alzheimer’s DiseaseMostafavi, S. and Jager, P.L., et al. | June 11, 2018There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),…sciencecityJune 11, 2018 Read More
Publications of the Week Endoplasmic Reticulum-Plasma Membrane Contact Sites Integrate Sterol and Phospholipid RegulationQuon, E. and Beh, C.T., et al. | June 8, 2018Although many of the "tether" proteins that staple the ER and the PM together had…sciencecityJune 8, 2018 Read More
Publications of the Week The Genome-Wide Rate and Spectrum of Spontaneous Mutations Differ Between Haploid and Diploid YeastSharp, N.P. and Otto, S.P., et al. | June 6, 2018Species vary substantially in how genetic material is transmitted from one generation to the next.…sciencecityJune 6, 2018 Read More
Publications of the Week MAP Kinase Signalling: Interplays Between Plant PAMP- and Effector-Triggered ImmunityThulasi Devendrakumar, K. and Zhang, Y., et al. | June 1, 2018In plants, mitogen-activated protein kinase (MAPK) cascades are involved in regulating many biological processes including…sciencecityJune 1, 2018 Read More
Publications of the Week Interpretable Dimensionality Reduction of Single Cell Transcriptome Data with Deep Generative ModelsDing, J, and Shah, S.P., et al. | May 30, 2018Single-cell RNA-sequencing has great potential to discover cell types, identify cell states, trace development lineages,…sciencecityMay 30, 2018 Read More
Publications of the Week Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian CancerZhang, A.W. and Shah, S.P., et al. | May 28, 2018High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns…sciencecityMay 28, 2018 Read More
Publications of the Week Listeria Membrane Protrusion Collapse: Requirement of Cyclophilin a for Listeria Cell-To-Cell SpreadingDhanda, A.S. and Guttman, J.A., et al. | May 25, 2018Listeria generate actin-rich tubular protrusions at the plasma membrane that propel the bacteria into neighbouring…sciencecityMay 25, 2018 Read More