Publications of the Week Higher-Order Epistasis Shapes the Fitness Landscape of a Xenobiotic-Degrading Enzyme Yang, G., et al. | November 5, 2019 Characterizing the adaptive landscapes that encompass the emergence of novel enzyme functions can provide molecular…sciencecityNovember 5, 2019 Read More
Publications of the Week Long Non-Coding RNAs Identify a Subset of Luminal Muscle-Invasive Bladder Cancer Patients with Favorable Prognosis de Jong, J.J., et al. | October 31, 2019 Background Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease, and gene expression profiling has identified…sciencecityOctober 31, 2019 Read More
Publications of the Week Dissociation of Solid Tumor Tissues with Cold Active Protease for Single-Cell RNA-Seq Minimizes Conserved Collagenase-Associated Stress Responses O’Flanagan, C.H., et al. | October 28, 2019 Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex biological systems, such as…sciencecityOctober 28, 2019 Read More
Publications of the Week Diversity of Small Molecule HIV-1 Latency Reversing Agents Identified in Low- and High-Throughput Small Molecule Screens Hashemi, P., and Sadowski, I. | October 25, 2019 The latency phenomenon produced by human immunodeficiency virus (HIV‐1) prevents viral clearance by current therapies,…sciencecityOctober 25, 2019 Read More
Publications of the Week Discordance in the Epithelial Cell-Dendritic Cell MHC Class II Immunoproteome: Implications for Chlamydia Vaccine Development Karunakaran, K.P., et al. | October 23, 2019 Chlamydia trachomatis and C. muridarum are intracellular bacterial pathogens of mucosal epithelial cells. CD4 T cells and major…sciencecityOctober 23, 2019 Read More
Publications of the Week The PedBE Clock Accurately Estimates DNA Methylation Age in Pediatric Buccal Cells McEwen, L.M., et al | October 21, 2019 DNA methylation is the most studied modification in human population epigenetics. Its information content can…sciencecityOctober 21, 2019 Read More
Publications of the Week Airway Epithelial Cell Isolation Techniques Affect DNA Methylation Profiles with Consequences for Analysis of Asthma Related Perturbations to DNA Methylation Clifford, R.L., et al. | October 18, 2019 The airway epithelium forms the interface between the inhaled environment and the lung. The airway…sciencecityOctober 18, 2019 Read More
Publications of the Week Rapid Selection and Identification of Functional CD8+ T Cell Epitopes from Large Peptide-Coding Libraries Sharma, G., et al. | October 16, 2019 Scientists have shown that we can harness the search-and-destroy functions of cytotoxic T cells (CTLs)…sciencecityOctober 16, 2019 Read More
Publications of the Week Rapid Selection and Identification of Functional CD8+ T Cell Epitopes from Large Peptide-Coding Libraries Sharma, G., et al. | October 16, 2019 Scientists have shown that we can harness the search-and-destroy functions of cytotoxic T cells (CTLs)…mjoyOctober 16, 2019 Read More
Publications of the Week Developing a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression across the Germ Cell Malignancy Spectrum Nappi, L., et al. | October 10, 2019 The authors evaluated operating characteristics, particularly specificity and positive predictive value (PPV), by mapping plasma…sciencecityOctober 10, 2019 Read More