Publications of the Week Breaking the Biomarker Code: PD-L1 Expression and Checkpoint Inhibition in Advanced NSCLCMelosky, B. and Hirsh, V., et al. | April 13, 2018Lung cancer is the most common cause of cancer-related death among males and the second…sciencecityApril 13, 2018 Read More
Publications of the Week IpdAB, a Virulence Factor in Mycobacterium Tuberculosis, Is a Cholesterol Ring-Cleaving HydrolaseCrowe, A.M. and Eltis, L.D., et al. | April 11, 2018All steroid-degrading bacteria utilize IpdAB, a predicted CoA transferase (CoT) that has been implicated in…sciencecityApril 11, 2018 Read More
Publications of the Week Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?Xue, Y.C. and Luo, H., et al. | April 9, 2018Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily attacks motor neurons in…sciencecityApril 9, 2018 Read More
Publications of the Week Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human AntibodiesChen, W.C. and Murawsky, C.M., et al. | April 6, 2018Therapeutic molecules derived from antibodies have become a dominant class of drugs used to treat…sciencecityApril 6, 2018 Read More
Publications of the Week Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral ReplicationMohamud, Y. and Luo, H., et al. | April 4, 2018Enteroviruses are responsible for an estimated 1 billion global infections per year. For most adults,…sciencecityApril 4, 2018 Read More
Publications of the Week Crystal Structure of an Intramembranal Phosphatase Central to Bacterial Cell-Wall Peptidoglycan Biosynthesis and Lipid RecyclingWorkman, S.D. and Strynadka, N.C.J., et al. | April 2, 2018Undecaprenyl pyrophosphate phosphatase (UppP) is an integral membrane protein that recycles the lipid carrier essential…sciencecityApril 2, 2018 Read More
Publications of the Week NHR-49/HNF4 Integrates Regulation of Fatty Acid Metabolism With a Protective Transcriptional Response to Oxidative Stress and FastingGoh, G.Y.S. and Taubert, S., et al. | March 30, 2018Oxidative stress occurs when excess reactive oxygen species (ROS), ubiquitous byproducts of aerobic respiration, are…sciencecityMarch 30, 2018 Read More
Publications of the Week ddPCRclust – an R Package and Shiny App for Automated Analysis of Multiplexed ddPCR DataBrink, B.G. and Brinkman, R.R., et al. | March 28, 2018Droplet digital PCR (ddPCR) is an emerging technology for quantifying DNA. By partitioning the target…sciencecityMarch 28, 2018 Read More
Publications of the Week The Yeast Ty1 Retrotransposon Requires Components of the Nuclear Pore Complex for Transcription and Genomic IntegrationManhas, S. and Measday, V., et al. | March 26, 2018In this publication, we tested a panel of NPC mutants for defects in Ty1 integration…sciencecityMarch 26, 2018 Read More
Publications of the Week Patient-Derived Hormone-Naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-Repressed Gene Driving the Development of Castration-Resistant Prostate CancerHao, J. and Wang Y., et al. | March 23, 2018This research directed by Dr. Yuzhuo Wang has led to the development of a panel…sciencecityMarch 23, 2018 Read More