Publications of the Week Systemic Study of Solvent-Assisted Active Loading of Gambogic Acid Into Liposomes and Its Formulation Optimization for Improved DeliveryTang, W.L. and Li, S.D., et al. | March 19, 2018The solvent-assisted active loading technology (SALT) was developed for encapsulating a water insoluble weak base…sciencecityMarch 19, 2018 Read More
Publications of the Week Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate CancerCi, X. and Wang, Y., et al. | March 16, 2018NEPC research by Dr. Yuzhuo Wang group has led to the development of a unique…sciencecityMarch 16, 2018 Read More
Publications of the Week Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461Prosser, K.E. and Walsby, C.J., et al. | March 12, 2018Low aqueous solubility is a major barrier to the clinical application of otherwise promising drug…sciencecityMarch 12, 2018 Read More
Publications of the Week HIC1 Links Retinoic Acid Signalling to Group 3 Innate Lymphoid Cell-Dependent Regulation of Intestinal Immunity and HomeostasisBurrows, K. and Zaph, C., et al. | March 9, 2018The intestinal immune system must be able to respond to a wide variety of infectious…sciencecityMarch 9, 2018 Read More
Publications of the Week Somatic IL4R Mutations in Primary Mediastinal Large B-Cell Lymphoma Lead to Constitutive JAK-STAT Signaling ActivationVigano, E. and Steidl, C., et al. | March 8, 2018Primary mediastinal large B cell lymphoma (PMBCL) is a distinct subtype of diffuse large B…sciencecityMarch 8, 2018 Read More
Publications of the Week N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus InfectionJagdeo, J.M. and Jan, E., et al. | March 5, 2018RNA viruses typically encode a limited number of proteins, yet during infection, these viral proteins…sciencecityMarch 5, 2018 Read More
Publications of the Week Non-Canonical Activation of Hedgehog in Prostate Cancer Cells Mediated by the Interaction of Transcriptionally Active Androgen Receptor Proteins with Gli3Li, N. and Buttyan, R., et al. | February 28, 2018Hedgehog is a cell signalling pathway needed for normal embryonic development. Hyperactive Hedgehog in adult…sciencecityFebruary 28, 2018 Read More
Publications of the Week PP2A Inhibition Sensitizes Cancer Stem Cells to ABL Tyrosine Kinase Inhibitors in BCR-ACL+ Human LeukemiaLai, D. and Jiang, X., et al. | February 26, 2018We have uncovered protein phosphatase 2A (PP2A) as a critical therapeutic target in drug-resistant blood…sciencecityFebruary 26, 2018 Read More
Publications of the Week CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary FunctionCanning, P. and Leroux, M.R., et al. | February 22, 2018Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of…sciencecityFebruary 22, 2018 Read More
Publications of the Week Harnessing Innate Lung Anti-Cancer Effector Functions with a Novel Bacterial-Derived ImmunotherapyBazett, M. and Mullins, D.W., et al. | February 20, 2018Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been…sciencecityFebruary 20, 2018 Read More